ID B7Q4I9_IXOSC Unreviewed; 287 AA.
AC B7Q4I9;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 24-JAN-2024, entry version 68.
DE RecName: Full=TIMELESS-interacting protein {ECO:0000256|RuleBase:RU366049};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW010640 {ECO:0000313|EMBL:EEC13761.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC13761.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC13761.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW010640-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW010640-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Plays an important role in the control of DNA replication and
CC the maintenance of replication fork stability.
CC {ECO:0000256|RuleBase:RU366049}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU366049}.
CC -!- SIMILARITY: Belongs to the CSM3 family. {ECO:0000256|ARBA:ARBA00006075,
CC ECO:0000256|RuleBase:RU366049}.
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DR EMBL; ABJB010158251; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010272300; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010745752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010818628; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010862377; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS856158; EEC13761.1; -; Genomic_DNA.
DR RefSeq; XP_002400649.1; XM_002400605.1.
DR AlphaFoldDB; B7Q4I9; -.
DR STRING; 6945.B7Q4I9; -.
DR PaxDb; 6945-B7Q4I9; -.
DR EnsemblMetazoa; ISCW010640-RA; ISCW010640-PA; ISCW010640.
DR KEGG; isc:IscW_ISCW010640; -.
DR VEuPathDB; VectorBase:ISCI010640; -.
DR VEuPathDB; VectorBase:ISCP_035202; -.
DR VEuPathDB; VectorBase:ISCW010640; -.
DR HOGENOM; CLU_971702_0_0_1; -.
DR InParanoid; B7Q4I9; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0031298; C:replication fork protection complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR GO; GO:0000076; P:DNA replication checkpoint signaling; IBA:GO_Central.
DR GO; GO:0043111; P:replication fork arrest; IBA:GO_Central.
DR GO; GO:0031297; P:replication fork processing; IEA:UniProtKB-UniRule.
DR InterPro; IPR012923; Csm3.
DR InterPro; IPR040038; TIPIN/Csm3/Swi3.
DR PANTHER; PTHR13220; TIMELESS INTERACTING-RELATED; 1.
DR PANTHER; PTHR13220:SF11; TIMELESS-INTERACTING PROTEIN; 1.
DR Pfam; PF07962; Swi3; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU366049};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU366049};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU366049};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 44..99
FT /note="Chromosome segregation in meiosis protein 3"
FT /evidence="ECO:0000259|Pfam:PF07962"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..143
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 287
FT /evidence="ECO:0000313|EMBL:EEC13761.1"
SQ SEQUENCE 287 AA; 31336 MW; 3E2335B8854701BE CRC64;
MDTLQEEEEG AVAAGGEGSD DQGGQEAEDV GTAGAKKVKN VVRKPQPKLN LEDLDTILGV
LDHWAHRTFP RFHSEFFYQR LESLGKKRQL QVYLRRLRLG LEDGVPLVGT VQDADDNALE
EVREDPFSSL LDGPRDSAAD DGETERPPSP QLPVHTSTTK PIQARPVGAK TVRTTTASAR
AKPIQARPVG ARTVRTTTAS ARLILPCLVE PTRVNPDLGK LQRVKLASGE PVGIVPTPRK
PTQAWHIWVE SAQTKAVPVM LVRVDLAQFR PIPIEPLETV QTGLVQA
//
