ID B7Q7A3_IXOSC Unreviewed; 514 AA.
AC B7Q7A3;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 08-NOV-2023, entry version 69.
DE SubName: Full=Beta-carotene dioxygenase, putative {ECO:0000313|EMBL:EEC14725.1, ECO:0000313|EnsemblMetazoa:ISCW021870-PA};
DE EC=1.14.99.36 {ECO:0000313|EMBL:EEC14725.1};
GN Name=8036943 {ECO:0000313|EnsemblMetazoa:ISCW021870-PA};
GN ORFNames=IscW_ISCW021870 {ECO:0000313|EMBL:EEC14725.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC14725.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC14725.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW021870-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW021870-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|PIRSR:PIRSR604294-1};
CC Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR604294-1};
CC -!- SIMILARITY: Belongs to the carotenoid oxygenase family.
CC {ECO:0000256|ARBA:ARBA00006787}.
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DR EMBL; ABJB010985394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS873409; EEC14725.1; -; Genomic_DNA.
DR RefSeq; XP_002412141.1; XM_002412096.1.
DR AlphaFoldDB; B7Q7A3; -.
DR STRING; 6945.B7Q7A3; -.
DR PaxDb; 6945-B7Q7A3; -.
DR EnsemblMetazoa; ISCW021870-RA; ISCW021870-PA; ISCW021870.
DR GeneID; 8036943; -.
DR KEGG; isc:IscW_ISCW021870; -.
DR VEuPathDB; VectorBase:ISCI021870; -.
DR VEuPathDB; VectorBase:ISCP_015266; -.
DR VEuPathDB; VectorBase:ISCW021870; -.
DR HOGENOM; CLU_016472_1_1_1; -.
DR InParanoid; B7Q7A3; -.
DR OMA; MHTIGDS; -.
DR OrthoDB; 294919at2759; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0003834; F:beta-carotene 15,15'-dioxygenase activity; IBA:GO_Central.
DR GO; GO:0010436; F:carotenoid dioxygenase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016121; P:carotene catabolic process; IBA:GO_Central.
DR GO; GO:0042574; P:retinal metabolic process; IBA:GO_Central.
DR InterPro; IPR004294; Carotenoid_Oase.
DR PANTHER; PTHR10543; BETA-CAROTENE DIOXYGENASE; 1.
DR PANTHER; PTHR10543:SF24; CAROTENOID ISOMEROOXYGENASE; 1.
DR Pfam; PF03055; RPE65; 1.
PE 3: Inferred from homology;
KW Dioxygenase {ECO:0000313|EMBL:EEC14725.1};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR604294-1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR604294-1};
KW Oxidoreductase {ECO:0000313|EMBL:EEC14725.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT BINDING 186
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 248
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 319
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 508
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
SQ SEQUENCE 514 AA; 57489 MW; 23683852ABEC9D55 CRC64;
MEGDADQTGA KDSPWLLTDL YGRSCLEEVE EPLRGRVTGV FPSWLRGRLL RNGPGLNFVG
PDRYQHAFDG LSLLRQFSVD SGEVSYRNRF LRSQAYVRNR KANRIVVAEF GTAAHPDPCA
GVFERLASVF TPTMTDNAVV SVMPIGDEFY AMTETPYVHR VDPATLETLS HEDLSKVVAV
HTITAHPLVD PEDGSTFNVG TQMGSRPAFV LIRFPPSVEC PDGSTSLREG KVVGRIPMQS
RFFPSYIHSF AMTENWLVVL EQSLVVSILK LFLAKAVGTS YGDTLSFDPS KKTRFHVMDK
RTGELFPVVF EAASFFTFHH VNAYERDREI VVDLCAFHDD AVIRNLRFAH SRPKKNDELA
SVHRFVLPLD PAVKSPAPVE SRVLSAELDG LALRAELPRI NDRFIGKPYR FAYLVGHSDG
LAEEWFVSKL NVESGHWARW KKPGWVPSEP VFVPRPGATD EDDGVVVFSL LDAKDENKLS
FVALDGRSFE EIARAEFETP SANPADFHGW FVPE
//
