ID B7Q8X6_IXOSC Unreviewed; 454 AA.
AC B7Q8X6;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Major facilitator superfamily associated domain-containing protein {ECO:0000259|Pfam:PF12832};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW020952 {ECO:0000313|EMBL:EEC15298.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC15298.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC15298.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW020952-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW020952-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. MFSD6 family.
CC {ECO:0000256|ARBA:ARBA00005241}.
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DR EMBL; ABJB010729700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS886620; EEC15298.1; -; Genomic_DNA.
DR RefSeq; XP_002405479.1; XM_002405435.1.
DR AlphaFoldDB; B7Q8X6; -.
DR PaxDb; 6945-B7Q8X6; -.
DR EnsemblMetazoa; ISCW020952-RA; ISCW020952-PA; ISCW020952.
DR KEGG; isc:IscW_ISCW020952; -.
DR VEuPathDB; VectorBase:ISCI020952; -.
DR VEuPathDB; VectorBase:ISCP_021743; -.
DR VEuPathDB; VectorBase:ISCW020952; -.
DR HOGENOM; CLU_013133_0_2_1; -.
DR InParanoid; B7Q8X6; -.
DR OMA; SHNETHF; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR024989; MFS_assoc_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR16172:SF30; SUGAR BABY, ISOFORM C; 1.
DR PANTHER; PTHR16172; UNCHARACTERIZED; 1.
DR Pfam; PF12832; MFS_1_like; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 42..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 72..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 343..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 11..448
FT /note="Major facilitator superfamily associated"
FT /evidence="ECO:0000259|Pfam:PF12832"
FT NON_TER 454
FT /evidence="ECO:0000313|EMBL:EEC15298.1"
SQ SEQUENCE 454 AA; 49769 MW; 0A656171465BFF34 CRC64;
MKWSFDKSLL PLKIHYFFCG AHIYVRVYYT SVGRRIGISE EAIAYIFGIL PIVVILVKFV
IAYIVDKTEK ASAMLIVLQA TLLVSNGVTF FSHYFQNQVK QTNVSVKCLE SIAFSPIQLS
SSLSFQNLSE SFLCNASCRA NESHTEPIAT IINFRPGNGS MFCRLKSWKG TPSDKSSCEL
SCMNKVVAAN AFSLWLYVVF VVTATAVSMA TMVVTDSATC EVLAEKGSFV GKLRLWAFVS
IGMSSLLIGA LIGVDNSGIE NNVGFTPCFY VVAVFALLDI LFLFRAPRLK MSNRSTSFFK
DTWTVLKSID MMVFSLFSCF IGAFGAFHVS YNVWFLEDIG SSQLTIGLAS AVQNLAVQAP
LLFVSGHIFK GLGYFLTCSL IFLAFALKFV GFSLIYNPWY AVVVDVTYGA AHSLMTGAMP
AFAQDRAPGG TVTTILSVLI ACTEGIGEYF SRLI
//
