ID B7QBP7_IXOSC Unreviewed; 467 AA.
AC B7QBP7;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=Proton-coupled zinc antiporter SLC30A9, mitochondrial {ECO:0000256|ARBA:ARBA00034845};
DE AltName: Full=Solute carrier family 30 member 9 {ECO:0000256|ARBA:ARBA00033405};
DE AltName: Full=Zinc transporter 9 {ECO:0000256|ARBA:ARBA00034922};
GN ORFNames=IscW_ISCW012178 {ECO:0000313|EMBL:EEC16269.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC16269.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC16269.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW012178-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW012178-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+)(out) + Zn(2+)(in) = 2 H(+)(in) + Zn(2+)(out);
CC Xref=Rhea:RHEA:72627, ChEBI:CHEBI:15378, ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00034428};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion membrane
CC {ECO:0000256|ARBA:ARBA00004225}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004225}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily.
CC {ECO:0000256|ARBA:ARBA00008873}.
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DR EMBL; ABJB010204906; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010339485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010516883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010776122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS902684; EEC16269.1; -; Genomic_DNA.
DR RefSeq; XP_002412961.1; XM_002412916.1.
DR AlphaFoldDB; B7QBP7; -.
DR STRING; 6945.B7QBP7; -.
DR PaxDb; 6945-B7QBP7; -.
DR EnsemblMetazoa; ISCW012178-RA; ISCW012178-PA; ISCW012178.
DR KEGG; isc:IscW_ISCW012178; -.
DR VEuPathDB; VectorBase:ISCI012178; -.
DR VEuPathDB; VectorBase:ISCP_001442; -.
DR VEuPathDB; VectorBase:ISCP_024093; -.
DR VEuPathDB; VectorBase:ISCW012178; -.
DR HOGENOM; CLU_021126_3_1_1; -.
DR InParanoid; B7QBP7; -.
DR OMA; YEFEPPI; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006882; P:intracellular zinc ion homeostasis; IBA:GO_Central.
DR GO; GO:0006829; P:zinc ion transport; IBA:GO_Central.
DR CDD; cd21078; NTD_ZNT9; 1.
DR Gene3D; 1.20.1510.10; Cation efflux protein transmembrane domain; 1.
DR Gene3D; 3.90.530.10; XPA C-terminal domain; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR040177; SLC30A9.
DR InterPro; IPR037129; XPA_sf.
DR NCBIfam; TIGR01297; CDF; 1.
DR PANTHER; PTHR13414; HUEL-CATION TRANSPORTER; 1.
DR PANTHER; PTHR13414:SF9; ZINC TRANSPORTER 9; 1.
DR Pfam; PF01545; Cation_efflux; 1.
DR SUPFAM; SSF161111; Cation efflux protein transmembrane domain-like; 1.
DR SUPFAM; SSF46955; Putative DNA-binding domain; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7QBP7};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc transport {ECO:0000256|ARBA:ARBA00022906}.
FT TRANSMEM 206..229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 241..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 467 AA; 52535 MW; 8C9E8B96CF75E41F CRC64;
MSEVQATIVK AVCGHRPKLD VTKEYTERNF VTPVRVMSEY MLKPSDLEGL RKIQRRSPYE
DAPPITVYLR KDVEAKALEM WGSYDAIRIE QQRRRDEELK YRESMSNVKS ILKEYQRAER
ASQEAKRRET ILKGSGRVVQ TAVVINGLNF AFKGIAWLYT GSHCMFAEAI HSLSDTCNQL
ILSFGIHKSI QEANPDHPYG YHNMRYVSSL ISGVGVFFFG AGLAWYHGIK GLLHPEELES
LYWAFFILGG SLISEGGTLL VAYNEVKKGA QREKMSMLEY VRRSRDPSVN VVLLEDLAAV
GGVAVAATCM GLAAHLGNPF YDALGSLLVG TLLSSVAAFI VYSNAAALVG RSIPFEAMQQ
INKELESDVM IRAIHDVKAT DMGNFVVRYK AEIDIDGREL TRSYLDTQDL ELLLEEVSRI
ETIEQLDAFM LKHGENIVDL LGAQVDRIEK NLKKRHPEVR HVDLEVL
//
