ID B7QC46_IXOSC Unreviewed; 1127 AA.
AC B7QC46;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 24-JAN-2024, entry version 79.
DE RecName: Full=Transient receptor potential cation channel, subfamily M, member 3 {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW013405 {ECO:0000313|EMBL:EEC16418.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC16418.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC16418.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW013405-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW013405-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; ABJB010217999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010250777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010418348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011012779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011124623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS904617; EEC16418.1; -; Genomic_DNA.
DR RefSeq; XP_002413110.1; XM_002413065.1.
DR AlphaFoldDB; B7QC46; -.
DR PaxDb; 6945-B7QC46; -.
DR EnsemblMetazoa; ISCW013405-RA; ISCW013405-PA; ISCW013405.
DR KEGG; isc:IscW_ISCW013405; -.
DR VEuPathDB; VectorBase:ISCI013405; -.
DR VEuPathDB; VectorBase:ISCP_009312; -.
DR VEuPathDB; VectorBase:ISCW013405; -.
DR HOGENOM; CLU_001390_0_3_1; -.
DR InParanoid; B7QC46; -.
DR OMA; YAIAYIC; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005261; F:monoatomic cation channel activity; IBA:GO_Central.
DR GO; GO:0098655; P:monoatomic cation transmembrane transport; IBA:GO_Central.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR PANTHER; PTHR13800:SF1; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 778..798
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 846..865
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 909..929
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 996..1019
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 32..301
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 787..1024
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC16418.1"
FT NON_TER 1127
FT /evidence="ECO:0000313|EMBL:EEC16418.1"
SQ SEQUENCE 1127 AA; 128585 MW; 784FF6AA66DB9763 CRC64;
EEHWSTSRHS EVSATDAFGT IEFHGTSHPL KAQYVRLVSD TRPEHVLQLF TREWQLELPK
LLITVHGGKA NFHLQSKLKK VLCRGLVKAA KTTGAWIFTG GTNTGVTRHV GEALLSERTP
QLRGRVVAIG IAPWGIIENR KDLIGAKRVV QYYSISSPKS RFAVLNQHHS YFVLADNGTT
GKYGAEIGLR KRLEKHISRQ KFYHRSNVQW CGIPVVCVIV EGGLNTVRTV LEYVTDLPPV
PVVVCDGSGR AADLIAFAHR YIPDDESKLP EGFRDQLITT IKKTFQIQQE QAEQVYVELL
QSIKKKDLIT VFRMGEGPCK ELDQAVLSAL LKGQFLPPVD QLNLALTWNR ADLARSDIFV
YGQEWAPGAL EQTMMDALTM DRVDFVQLLL ENGVSMHKFL TIPRLEELYC TKHGPSNTFR
FLVKEVRKNL PSGYRYTLYD IGLVVEKLMG GAYRSAYCRR KFRNLYSTVM RRMSTVSTLR
INRIENNVEK SAPTLHTALN TEASAALLGT DSTFSHPFNE LLIWAVLMKR QKMATFMWQN
GEEAIVRALV ASKLYWAMAH EAAQDDLEAD ASEELRHNAR EFEKLALDLL DYCYRQDEGT
TLQLLTHELQ NWSKQTCLGL AVAANHSGFL AHTANQMLLA ELWMGALRTR KNVSLKVIFG
LLFPPTVLWL EFKSKEELQL MPQTEEEHYL DLQDDEEDSN PDVDDPPGVL NPPVINLDTD
SLGGPLARKC SSVFNRLENG SLFPMDTDAA YLKIRTRKRP LRLGRKIYEF YAAPVTKFWS
HAIAYGIFLC FFTFVVLVKM RPEPSWQEVY VIAYIVTLAV EKIREAMMSE PENFTQKIIV
WAVKKWNPCD VVVIVVFLVG VALRFTPSSH AEGRLLYCLT IMYWYIRLLD ILSVNKYLGP
YVTMIGKMVI NMMYFVVLLL VILMSYGVAR QSILHPQETA SWGLVKNIFF MPYWMIYGEV
FADSIDRECL TAVCKTDGKP GEYTCQTGSW INPAIMAVYL LVANILLVNL LIAVFNNIFI
EVNAISQHVW KSQRFTVVME YEQKPVLPPP LIVLSHLHLA VKCGYRWWKG KSRTFDHGLK
LFLDESDIER IHDFEQECVE GYFRESEVRM QMTTENRVLT TTERYGG
//