ID B7QCL5_IXOSC Unreviewed; 688 AA.
AC B7QCL5;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Metabotropic glutamate receptor 4, 6, 7, putative {ECO:0000313|EMBL:EEC16587.1, ECO:0000313|EnsemblMetazoa:ISCW013154-PA};
GN ORFNames=IscW_ISCW013154 {ECO:0000313|EMBL:EEC16587.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC16587.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC16587.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW013154-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW013154-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR EMBL; ABJB010091563; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010146829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010330361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010549281; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010824470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010830519; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011073041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS908406; EEC16587.1; -; Genomic_DNA.
DR RefSeq; XP_002413279.1; XM_002413234.1.
DR AlphaFoldDB; B7QCL5; -.
DR STRING; 6945.B7QCL5; -.
DR PaxDb; 6945-B7QCL5; -.
DR EnsemblMetazoa; ISCW013154-RA; ISCW013154-PA; ISCW013154.
DR KEGG; isc:IscW_ISCW013154; -.
DR VEuPathDB; VectorBase:ISCI013154; -.
DR VEuPathDB; VectorBase:ISCP_029721; -.
DR VEuPathDB; VectorBase:ISCW013154; -.
DR HOGENOM; CLU_005389_4_2_1; -.
DR InParanoid; B7QCL5; -.
DR OMA; PKDETQC; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001640; F:adenylate cyclase inhibiting G protein-coupled glutamate receptor activity; IBA:GO_Central.
DR CDD; cd15045; 7tmC_mGluRs; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060:SF176; MANGETOUT, ISOFORM G; 1.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:EEC16587.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 385..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 455..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 497..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 544..567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 579..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 611..636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 385..651
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 688 AA; 76630 MW; B9BCEF5256F68CF9 CRC64;
MVEIVKLLKW TYVSILYEES NYGLKAFNEL EEQLKSENIC IAIKEKLTKD SGVAAEDSYD
NIIRNLLSKQ RARGVIVFGS DQEVAGVMRA VRRNNATGHF SWIGSDGWSA RAVVFEDHEA
QVEGTLSVQP QARKVEGFDD YFLSLTVDNN RRNPWFTEFW EHFFKCKWPG SLVTPYNQDY
ARRCTGHERL SRSQGYEPER QLQFVGDAVL AFAYALRDMH RSLCGANYVG LCDRMDPVDG
TELLGFLQDV EFTGLSGETF RFSEHGDGPA RYNILHFKQV RRGDYRWVPV GDYRDGSLRL
DMSQLQFRLD DPAMPRSVCS EPCPRGWATR LVEGESCCWH CLRCTDYQFL VSGGCAECAP
GTLPDPFHER CLPVPESHMS PGSPWAAAAL ALASLGALAA LAVLAVFLAY RDTPVVRASG
RELSCVLLAG ILLCHGTALL LVQRPSAAVC GAQRAALGLC FAVVYSAILA KTDRIARIFR
AGRRSAQRPG CISPRSQLAL CGALVSVQGL VAALWLALRP PRAVHHHPTR EDNQLVCLAS
VQRAGYALAL AYPLCLVAVC TVYAVLTRKI PEAFNESKYI GFAMYTTCVI WLAFLPIYLT
TWRHVNLNLT SMAVAVSLSA SVTLACLFVP KLYIILLHPE KNVRQSIMAK YGTLKNQQQH
RVESATQSDG ACFLLPYWRA SRRKFTPA
//
