ID B7QCQ7_IXOSC Unreviewed; 570 AA.
AC B7QCQ7;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=LIM domain-binding protein, putative {ECO:0000313|EMBL:EEC16629.1, ECO:0000313|EnsemblMetazoa:ISCW022782-PA};
DE EC=2.7.11.1 {ECO:0000313|EMBL:EEC16629.1};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW022782 {ECO:0000313|EMBL:EEC16629.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC16629.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC16629.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW022782-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW022782-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the paxillin family.
CC {ECO:0000256|ARBA:ARBA00005813}.
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DR EMBL; ABJB010302064; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010444750; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010500264; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010538503; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010622689; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010635193; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010728323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010828309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010891846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010947059; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS909250; EEC16629.1; -; Genomic_DNA.
DR RefSeq; XP_002413321.1; XM_002413276.1.
DR AlphaFoldDB; B7QCQ7; -.
DR STRING; 6945.B7QCQ7; -.
DR PaxDb; 6945-B7QCQ7; -.
DR EnsemblMetazoa; ISCW022782-RA; ISCW022782-PA; ISCW022782.
DR KEGG; isc:IscW_ISCW022782; -.
DR VEuPathDB; VectorBase:ISCI022782; -.
DR VEuPathDB; VectorBase:ISCP_000346; -.
DR VEuPathDB; VectorBase:ISCW022782; -.
DR HOGENOM; CLU_001357_8_1_1; -.
DR InParanoid; B7QCQ7; -.
DR OMA; GAPYCKL; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR GO; GO:0031941; C:filamentous actin; IBA:GO_Central.
DR GO; GO:0001725; C:stress fiber; IBA:GO_Central.
DR GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051371; F:muscle alpha-actinin binding; IBA:GO_Central.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0061061; P:muscle structure development; IBA:GO_Central.
DR CDD; cd09455; LIM1_Enigma_like_1; 1.
DR CDD; cd09461; LIM3_Enigma_like_1; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 3.
DR InterPro; IPR031847; PDLI1-4/Zasp-like_mid.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR006643; Zasp-like_motif.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24214; PDZ AND LIM DOMAIN PROTEIN ZASP; 1.
DR PANTHER; PTHR24214:SF38; PDZ AND LIM DOMAIN PROTEIN ZASP; 1.
DR Pfam; PF15936; DUF4749; 1.
DR Pfam; PF00412; LIM; 3.
DR Pfam; PF00595; PDZ; 1.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SMART; SM00132; LIM; 3.
DR SMART; SM00735; ZM; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 3.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000313|EMBL:EEC16629.1};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 1..53
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 455..514
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 515..570
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT REGION 187..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..256
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..325
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC16629.1"
SQ SEQUENCE 570 AA; 59602 MW; A111802CCAD9C3A9 CRC64;
VNPGSLAEKG GLQVGDALLR IQGKSTDELR HKDAQDAIVR AGNYLELSVQ RRPKVTPVGA
APRPGPISNG EPAPVTKTSL AANKQAYTTN AQCSNYLCAG IARMKQPYKP IGTGHNTAAK
PFGGTMAAVV HNQYNSPAPI YSMNNIADTL SKQTEVLTSG AVGGGHLPQN VPLAPLAPLA
PLTSTSPAAP MSGVGQTPPP PLFSASPKFT SSTAPFTPSQ AAPMHSPSNS TPSVPTYRPP
PGTQRVVPPP PVAGVPKFGA QTPTSFQPAA APPYFPPPAA PMSYSPVMSP ASSRPSSFVS
SSAGSPIPPL SASAKVPPPT APKPSSAVRA GPQVAARPKP GGGGPWAANG MASGGSAPFA
TGTSGLSQGV GSRPAPKRGR GMLSQQVAIG GKIPICSNCG SPIRGPFVTA MGKNWCPDHF
LCANASCRRS LQDIGFVEEQ SKLYCEHCYE SYMAPVCRKC GHRIKGDCLN ALEQTWHPEC
FVCSYCKTAF GNSSFYLEDG MPYCEKDWNE LFTTKCVGCG FPIEAGDRWV EALNNNYHSQ
CFKCTICHKN LEGQSFFAKG GRPFCKAHAR
//
