ID B7QCS5_IXOSC Unreviewed; 1056 AA.
AC B7QCS5;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Furrowed, putative {ECO:0000313|EMBL:EEC16647.1, ECO:0000313|EnsemblMetazoa:ISCW022311-PA};
DE EC=3.4.21.104 {ECO:0000313|EMBL:EEC16647.1};
DE EC=3.4.21.84 {ECO:0000313|EMBL:EEC16647.1};
GN ORFNames=IscW_ISCW022311 {ECO:0000313|EMBL:EEC16647.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC16647.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC16647.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW022311-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW022311-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR EMBL; ABJB010102893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010189053; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010257810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010264203; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010487805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010489805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010587515; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010794803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS909431; EEC16647.1; -; Genomic_DNA.
DR RefSeq; XP_002413339.1; XM_002413294.1.
DR AlphaFoldDB; B7QCS5; -.
DR STRING; 6945.B7QCS5; -.
DR PaxDb; 6945-B7QCS5; -.
DR EnsemblMetazoa; ISCW022311-RA; ISCW022311-PA; ISCW022311.
DR KEGG; isc:IscW_ISCW022311; -.
DR VEuPathDB; VectorBase:ISCI022311; -.
DR VEuPathDB; VectorBase:ISCP_022706; -.
DR VEuPathDB; VectorBase:ISCP_030369; -.
DR VEuPathDB; VectorBase:ISCW022311; -.
DR HOGENOM; CLU_282902_0_0_1; -.
DR InParanoid; B7QCS5; -.
DR OMA; DWCPEPP; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 10.
DR CDD; cd00037; CLECT; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 10.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR006585; FTP1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR19325; COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR19325:SF537; FURROWED, ISOFORM A; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF00084; Sushi; 10.
DR SMART; SM00032; CCP; 10.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00607; FTP; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 10.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS50923; SUSHI; 10.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000313|EMBL:EEC16647.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1056
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010826848"
FT TRANSMEM 875..897
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 119..237
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 250..307
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 308..367
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 368..425
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 426..485
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 486..543
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 544..603
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 604..669
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 670..729
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 730..788
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 789..848
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 976..1056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1005..1056
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 278..305
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 338..365
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 396..423
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 456..483
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 514..541
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 574..601
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 640..667
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 700..727
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 759..786
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 819..846
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 1056 AA; 115328 MW; 21CB71B96B4D05E6 CRC64;
MSEPDKLILV VLARTLVNVA SCKPTRPVEH AVNVAYGKPT NQSSTVRGGD SKNANDGDLT
TLHENRFCTE TKLENAPWWQ VDLLQPYEVR VIRLLTRGCC EFSPDRCGNR VEPLELTTFI
RKCYEFQGSR GGSFQDASAY CQTRGGLLVH GVDDLILPFI SAELERRRDK LKSKLVWMGA
QRRTGIGLNK RGWYWVNGDP VREFLWAEDQ PNNYNGQQNC VVIDGGRKWR WNDVTCDLDY
LPWICQYNPS NCGSPDKKEN STTAGQDYRV GQEVSYDCPT GSLLVGSRTR KCAVSGFWTG
SAPSCKYMDC GNPESVENGQ FVLLHRRTTF NATVEYVCDA NYTLVGKPRR MCGEDGRWNG
SQPSCLRDFC SELAPTPSSS VQVQGLRFGD RARYTCKMGH KLIGNDTRYC QLGGNWSGDE
PTCKYIDCGE PRPLDDGEVL LVNGTSTFLS VVKYSCHDNF TLSGVDTRSC LETGLWSDVE
PTCDMISCGE PEIPLGGYVV EEDFQVHDTV HYKCHPGHVM AGHETRTCLR DGTWSGSAPT
CSFVDCGRVP PILKGEVAYE NGTTFLGSRI VHGCSAGYRL TGVRVRTCGL EGRWSGTPPK
CEEIRCKPPE VPKNATVVYG DNDRSSAESF KIASTVQYRC VTGHIVQGES LRTCQVTGEW
TGEVPECVYV ECSFPLPIGN GHWLLSTNST HYGATVEYEC DRNYQLDGAP RRLCLENGTW
SGPEPLCLEV RCAEPKASDS WTVIKFSDDS VGSSVEYSCE QGYELQGLTT RICQANGLWS
GDASTCALVD CGRPSVIGNG RGQLLNGSTT FGSLVEYQCL HEFKLVGEAL RTCGADGQWS
GQEPRCTDVP VRDSNDVEGA DSNRADFTYD SSRTVGIAIA VGAGALLVIA IVVAIVWMRT
KAQRVKNTEN VEVNRNVEKD NATVMSFSRL ALEAAEANSA PYHNGPGIRH NPNGLVTFAA
GPQPIYANVT VNGQSLSTSN SSGRGNLGVP PSPPHAPPRH NGNPAGNHHH SSSHNSSHNG
SHNGSHNSGH NRGSHGGNGS LTANGHMTST LQSHDV
//
