ID B7QDU6_IXOSC Unreviewed; 369 AA.
AC B7QDU6;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Gastric triacylglycerol lipase, putative {ECO:0000313|EMBL:EEC17018.1, ECO:0000313|EnsemblMetazoa:ISCW012188-PA};
DE EC=3.1.1.3 {ECO:0000313|EMBL:EEC17018.1};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW012188 {ECO:0000313|EMBL:EEC17018.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC17018.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC17018.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW012188-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW012188-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ABJB010242144; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010274984; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010847387; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011020879; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011134207; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS915699; EEC17018.1; -; Genomic_DNA.
DR RefSeq; XP_002413710.1; XM_002413665.1.
DR AlphaFoldDB; B7QDU6; -.
DR STRING; 6945.B7QDU6; -.
DR ESTHER; ixosc-b7qdu6; Acidic_Lipase.
DR PaxDb; 6945-B7QDU6; -.
DR EnsemblMetazoa; ISCW012188-RA; ISCW012188-PA; ISCW012188.
DR KEGG; isc:IscW_ISCW012188; -.
DR VEuPathDB; VectorBase:ISCI023846; -.
DR VEuPathDB; VectorBase:ISCP_035332; -.
DR VEuPathDB; VectorBase:ISCW012188; -.
DR HOGENOM; CLU_010974_0_3_1; -.
DR InParanoid; B7QDU6; -.
DR OMA; YACEEHT; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0004806; F:triglyceride lipase activity; IEA:UniProtKB-EC.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR006693; AB_hydrolase_lipase.
DR InterPro; IPR025483; Lipase_euk.
DR PANTHER; PTHR11005:SF163; LIPASE; 1.
DR PANTHER; PTHR11005; LYSOSOMAL ACID LIPASE-RELATED; 1.
DR Pfam; PF04083; Abhydro_lipase; 1.
DR PIRSF; PIRSF000862; Steryl_ester_lip; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:EEC17018.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 2..62
FT /note="Partial AB-hydrolase lipase"
FT /evidence="ECO:0000259|Pfam:PF04083"
FT ACT_SITE 137
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT ACT_SITE 309
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT ACT_SITE 340
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC17018.1"
SQ SEQUENCE 369 AA; 41765 MW; F4EAAB7027B8DD50 CRC64;
SLIASKGYQV EEYEVTTSDG YILAVQRIPE GRSNALRIQD TPKKVVFLLH GLLGSSADWV
LNYPPQSLGF ILADAGYDVW LGNVRGNTYS RHVKYNRRSK EFWNFSVDEM IERDLPETLD
FVLKRTGRRK LFFVGHSQGT SIMFGLLSLR PEYSEKIKLF CALGPVSAIT NTRSPMRYMS
PFGKYIGAFV NSLGRYEFLP NNFVMKLLAD AVCRHEGPRD VCGNIVFLIY GPETMELNVT
RLPVFLCHVP AGTSVRTMVH YSQILISGRF QKFDFGENRN QLVYGASTPP EYDVSRVAVP
VALFWSEGDW MADPRDVALL RRRLPNVVLD FKVSQPKFSH IDFAAGIHAK ALVYEPMMKL
MASYKSAGE
//
