ID B7QEQ9_IXOSC Unreviewed; 279 AA.
AC B7QEQ9;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=Carboxylic ester hydrolase {ECO:0000256|RuleBase:RU361235};
DE EC=3.1.1.- {ECO:0000256|RuleBase:RU361235};
DE Flags: Fragment;
GN Name=8040148 {ECO:0000313|EnsemblMetazoa:ISCW022255-PA};
GN ORFNames=IscW_ISCW022255 {ECO:0000313|EMBL:EEC17331.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC17331.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC17331.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW022255-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW022255-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC {ECO:0000256|ARBA:ARBA00005964, ECO:0000256|RuleBase:RU361235}.
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DR EMBL; ABJB010293106; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS921995; EEC17331.1; -; Genomic_DNA.
DR RefSeq; XP_002414023.1; XM_002413978.1.
DR AlphaFoldDB; B7QEQ9; -.
DR STRING; 6945.B7QEQ9; -.
DR PaxDb; 6945-B7QEQ9; -.
DR EnsemblMetazoa; ISCW022255-RA; ISCW022255-PA; ISCW022255.
DR KEGG; isc:IscW_ISCW022255; -.
DR VEuPathDB; VectorBase:ISCI022255; -.
DR VEuPathDB; VectorBase:ISCP_033169; -.
DR VEuPathDB; VectorBase:ISCW022255; -.
DR HOGENOM; CLU_006586_4_2_1; -.
DR InParanoid; B7QEQ9; -.
DR OMA; TEENIGP; -.
DR OrthoDB; 3019516at2759; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0003990; F:acetylcholinesterase activity; IBA:GO_Central.
DR GO; GO:0006581; P:acetylcholine catabolic process; IBA:GO_Central.
DR GO; GO:0019695; P:choline metabolic process; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002018; CarbesteraseB.
DR InterPro; IPR019826; Carboxylesterase_B_AS.
DR InterPro; IPR019819; Carboxylesterase_B_CS.
DR PANTHER; PTHR43918; ACETYLCHOLINESTERASE; 1.
DR PANTHER; PTHR43918:SF4; CARBOXYLIC ESTER HYDROLASE; 1.
DR Pfam; PF00135; COesterase; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
DR PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361235};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Serine esterase {ECO:0000256|ARBA:ARBA00022487};
KW Signal {ECO:0000256|RuleBase:RU361235}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|RuleBase:RU361235"
FT CHAIN 22..279
FT /note="Carboxylic ester hydrolase"
FT /evidence="ECO:0000256|RuleBase:RU361235"
FT /id="PRO_5010753495"
FT DOMAIN 24..272
FT /note="Carboxylesterase type B"
FT /evidence="ECO:0000259|Pfam:PF00135"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC17331.1"
FT NON_TER 279
FT /evidence="ECO:0000313|EMBL:EEC17331.1"
SQ SEQUENCE 279 AA; 30429 MW; A91DEE911F194762 CRC64;
LTAVILLWIF YLLETVRPVV GDLPHVRVDS GLIAGTRVQV AEKEVEAFLG IPYAVPPIGE
LRFKKPQPIL PWNGTYNASS KPSPCWQLDL YFMENGALNY SSASEDCLYL NIWRPVSPCM
KTNSCDKKLP VVVFIHGGAF QWGDSSLFLY DPANFVAMSD VVFVTFNYRL SILGFLSLEI
PALPGNMGLW DQNLVLKWVQ KNIANFGGDP NEVTLSGQSA GAISVGLHAI SPHSQGLFKR
AILQSGTQLS TVFGVSNRGT AKNTAITAAL GCFENGKTM
//
