ID B7QF68_IXOSC Unreviewed; 156 AA.
AC B7QF68;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=rRNA methylase, putative {ECO:0000313|EMBL:EEC17490.1, ECO:0000313|EnsemblMetazoa:ISCW013078-PA};
DE EC=2.1.1.34 {ECO:0000313|EMBL:EEC17490.1};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW013078 {ECO:0000313|EMBL:EEC17490.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC17490.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC17490.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW013078-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW013078-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC superfamily. RNA methyltransferase TrmH family.
CC {ECO:0000256|ARBA:ARBA00007228}.
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DR EMBL; ABJB010238601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS924397; EEC17490.1; -; Genomic_DNA.
DR RefSeq; XP_002414182.1; XM_002414137.1.
DR AlphaFoldDB; B7QF68; -.
DR STRING; 6945.B7QF68; -.
DR PaxDb; 6945-B7QF68; -.
DR EnsemblMetazoa; ISCW013078-RA; ISCW013078-PA; ISCW013078.
DR KEGG; isc:IscW_ISCW013078; -.
DR VEuPathDB; VectorBase:ISCI013078; -.
DR VEuPathDB; VectorBase:ISCP_013944; -.
DR VEuPathDB; VectorBase:ISCW013078; -.
DR HOGENOM; CLU_021322_4_5_1; -.
DR InParanoid; B7QF68; -.
DR OMA; MTHRCSA; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0141100; F:tRNA (guanine(18)-2'-O)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0031167; P:rRNA methylation; IEA:InterPro.
DR CDD; cd18105; SpoU-like_MRM1; 1.
DR Gene3D; 3.40.1280.10; -; 1.
DR InterPro; IPR029028; Alpha/beta_knot_MTases.
DR InterPro; IPR047182; MRM1.
DR InterPro; IPR047261; MRM1_MeTrfase_dom.
DR InterPro; IPR001537; SpoU_MeTrfase.
DR InterPro; IPR029026; tRNA_m1G_MTases_N.
DR PANTHER; PTHR46103; RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR46103:SF1; RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL; 1.
DR Pfam; PF00588; SpoU_methylase; 1.
DR SUPFAM; SSF75217; alpha/beta knot; 1.
PE 1: Evidence at protein level;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EEC17490.1};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7QF68};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EEC17490.1}.
FT DOMAIN 7..156
FT /note="tRNA/rRNA methyltransferase SpoU type"
FT /evidence="ECO:0000259|Pfam:PF00588"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC17490.1"
FT NON_TER 156
FT /evidence="ECO:0000313|EMBL:EEC17490.1"
SQ SEQUENCE 156 AA; 16700 MW; 50A22925D8EC2257 CRC64;
GVLNDRLWVL MDRIQDPMNF GAVLRSSYYF GVQKVFTTRT DSCRLSPVVS KASSGALEVM
DLYSLQSPAE FLQALKSKGW WVVGTAGVKQ DGPFEAGPRS DLSWVLPPTD KPAILIVGNE
NQGMHPELGA VCDSVLSISP AASSDLIGSL NVSVAT
//
