ID B7QHG3_IXOSC Unreviewed; 1244 AA.
AC B7QHG3;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 110.
DE SubName: Full=Pdz domain-containing guanine nucleotide exchange factor, pdz-gef, putative {ECO:0000313|EMBL:EEC18285.1, ECO:0000313|EnsemblMetazoa:ISCW014925-PA};
GN ORFNames=IscW_ISCW014925 {ECO:0000313|EMBL:EEC18285.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC18285.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC18285.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW014925-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW014925-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RAPGEF2 family.
CC {ECO:0000256|ARBA:ARBA00010829}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ABJB010067084; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010078287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010175782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010781717; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010789846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010850544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010925284; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS939598; EEC18285.1; -; Genomic_DNA.
DR RefSeq; XP_002414620.1; XM_002414575.1.
DR AlphaFoldDB; B7QHG3; -.
DR STRING; 6945.B7QHG3; -.
DR PaxDb; 6945-B7QHG3; -.
DR EnsemblMetazoa; ISCW014925-RA; ISCW014925-PA; ISCW014925.
DR KEGG; isc:IscW_ISCW014925; -.
DR VEuPathDB; VectorBase:ISCI014925; -.
DR VEuPathDB; VectorBase:ISCP_026622; -.
DR VEuPathDB; VectorBase:ISCW014925; -.
DR HOGENOM; CLU_002782_2_2_1; -.
DR InParanoid; B7QHG3; -.
DR OMA; GTCEYEF; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0016324; C:apical plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01785; RA_PDZ-GEF1; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF249; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 2; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 1: Evidence at protein level;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7QHG3};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 186..291
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 317..430
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 434..506
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 675..761
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 786..1013
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 93..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1072..1128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1141..1193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1095..1125
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1161..1175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1244 AA; 138638 MW; 40F458E9DD9EAAB8 CRC64;
MLRFESRDVD LAEYQGEADA ICRAKCEAAA KIDYPDCELL RPGQRQSCTT MNLERLLALE
PDEVAVETRL PHHHHLQQLP LDCQQTALHR EGLLKSNRSS RSSDTSSAYS GSDTMQSVQS
SLEDNEVDFT GLVESAVDSD EEEDLAESID SLTVRDTYHE CLEKDPNDRT EDDIETLLEF
MQPLPAFANM TLSVRRELCA VMVFAVVEKA GTVVMNDGEE LDSWSVIVNG QVEVELPDGT
VRELAMGDSF GITPTTEKMH HQGTMRTKLD DCQFVCIAQG DYYRILHRSE ENTCKHEEDG
RVVLVTEHRT VDSGSREGHI VIRGTPERLL SQLFEENALD PGYIEDFLLT YRTFIPSSHV
VCTKLLSWFK DPALRDKVTR VVLLWVNNHF TDFETDSEMM EFLEQFEQCL EAQKMHAQLR
LLNIACATKA RTRVVTLARS SRDDLLPFSI LGGYETGNAI FVAKVDKANS KAEDGWLKRG
DEILEVNGQS FATMSHTQAL EILRKATHLC ITVRSNLLEF KEMLNNPEKA MRPRGRKSSE
FSRLQPDSRL RLSSHLEWGD VVGLPLGVGG LPLGVGWSPH PGTAPAGASP AIGTGTTAAH
APGAVTTAVV VTGNGDLAKE DKKGFMTLGH RAKLKKALAK MNIIPKTLNS HSNPDLSSLL
VTHCGDAEGP TRDFPEHVLK VYKSDQTCKY LLVHRETTAR EVVMLALREF GISDSSSLYS
LCEVSVGEGG LIKQRRLPEQ MQHLAEKIGL NSRYYLKNNS STDPLVPDDL ASELLRESQV
NFLQLNSVEV ATQLTLEDFS IFRQIEPTEY IDDLFEVKSA YGSPMLSLFA ELVNREMFWV
VSEICGESNP IRRMKTVKQF VKVARQCKEC KNFNSMFAIL SGLGHGAVSR LRSTWDKLPT
KYQKMFEDLQ ELMDPSRNMC KYRNLINSEQ MRPPIIPFYP IVKKDLTFIH FGNDTIVDNL
VNFEKLRMIA KEVRQLMNMC SVPYDLYTML EAGGSPLNPA LASLNSFAAA AVAGTGASAM
LARRRKRSTA QPSPKKMFEE AQMVRRVKAY LAHLRVVTDE TRLLTMSMEC EPHPVPPVPT
NVHPQRKRNP SPRKRHPSPT LSTASSNSST SEGKKSINSA GGVKFGTDSP QAMRKLLALS
DQSKVRPHQP PRPPASPSPG IKRRGSTTRE LPSQATAVAG ATCHGRSHSD TGYVQPVDLS
AESSSVTSLN NLPLRKSHVS ELENSSFSKK LCMYQISTYI EKII
//
