ID B7QHI0_IXOSC Unreviewed; 458 AA.
AC B7QHI0;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Zinc finger protein, putative {ECO:0000313|EMBL:EEC18302.1, ECO:0000313|EnsemblMetazoa:ISCW014883-PA};
DE EC=2.7.1.150 {ECO:0000313|EMBL:EEC18302.1};
GN ORFNames=IscW_ISCW014883 {ECO:0000313|EMBL:EEC18302.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC18302.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC18302.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW014883-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW014883-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ABJB010003685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010007226; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010008988; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010056714; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010832035; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011134504; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS939631; EEC18302.1; -; Genomic_DNA.
DR RefSeq; XP_002414637.1; XM_002414592.1.
DR AlphaFoldDB; B7QHI0; -.
DR STRING; 6945.B7QHI0; -.
DR PaxDb; 6945-B7QHI0; -.
DR EnsemblMetazoa; ISCW014883-RA; ISCW014883-PA; ISCW014883.
DR KEGG; isc:IscW_ISCW014883; -.
DR VEuPathDB; VectorBase:ISCI014883; -.
DR VEuPathDB; VectorBase:ISCP_032902; -.
DR VEuPathDB; VectorBase:ISCW014883; -.
DR HOGENOM; CLU_597563_0_0_1; -.
DR InParanoid; B7QHI0; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR GO; GO:0005545; F:1-phosphatidylinositol binding; IBA:GO_Central.
DR GO; GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR CDD; cd15733; FYVE_MTMR4; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR046978; MTMR4_FYVE.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46465; LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG; 1.
DR PANTHER; PTHR46465:SF2; LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG; 1.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transferase {ECO:0000313|EMBL:EEC18302.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 365..425
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 31..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 254..281
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 119..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 458 AA; 48970 MW; A48FFDD5382AF1C7 CRC64;
MCLTPVVIVR RHQRRLSDSS LKGFPMELHS HEDAACQPSP SKHSCPDLVS EPSPGGPAVV
LGSGAEDDGP REGPANEAPS IDGSTDTLVN EIGQQSSSVG ADDGVLQKTM PEPAELSPAQ
LDQQLSNTAS TSTTDLRSSA GAVLGGGYSE LPLEEVAPGK CVVCLSRKNG HENLLAATRS
SLARSAAAAT TNGGRFSHYS TPMHSRTPSS GFPATPCDDR LLLDPMASRT QSSQASCQQQ
FDVDGLNTPV DALQQRIHQM VLDHEAKIEN LENELRRARF ALDQRSLHHN GKEASEALED
AVSLFWNSPC LQHLCSGAME MELGLDCACS GEPPWGGCQD GSSSSELSWE QVDEREARAT
LWVPDHAASH CTACGAEFWI GRRKHHCRNC GNVFCSQCAS QMHPVPHEQL YQPVRVCSSC
FEALRSRPCR PSALLAAPGP HSERILAKTS PAVTAASN
//
