ID B7QK63_IXOSC Unreviewed; 515 AA.
AC B7QK63;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE SubName: Full=Zinc finger, C4 type, putative {ECO:0000313|EMBL:EEC19235.1, ECO:0000313|EnsemblMetazoa:ISCW023325-PA};
GN ORFNames=IscW_ISCW023325 {ECO:0000313|EMBL:EEC19235.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC19235.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC19235.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW023325-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW023325-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000256|RuleBase:RU004334}.
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DR EMBL; ABJB010765147; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010969281; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS957126; EEC19235.1; -; Genomic_DNA.
DR RefSeq; XP_002415570.1; XM_002415525.1.
DR AlphaFoldDB; B7QK63; -.
DR STRING; 6945.B7QK63; -.
DR PaxDb; 6945-B7QK63; -.
DR EnsemblMetazoa; ISCW023325-RA; ISCW023325-PA; ISCW023325.
DR KEGG; isc:IscW_ISCW023325; -.
DR VEuPathDB; VectorBase:ISCI023325; -.
DR VEuPathDB; VectorBase:ISCP_021347; -.
DR VEuPathDB; VectorBase:ISCP_029278; -.
DR VEuPathDB; VectorBase:ISCW023325; -.
DR HOGENOM; CLU_001479_2_1_1; -.
DR InParanoid; B7QK63; -.
DR OMA; LVEMDCL; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0034056; F:estrogen response element binding; IBA:GO_Central.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07168; NR_DBD_DHR4_like; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR48092; KNIRPS-RELATED PROTEIN-RELATED; 1.
DR PANTHER; PTHR48092:SF18; NUCLEAR RECEPTOR SUBFAMILY 6 GROUP A MEMBER 1; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 103..178
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 293..515
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 38..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 515 AA; 56242 MW; 5295E272FD75CD53 CRC64;
MSWTPPSEAR SSDSGGGGYA TYATYQRSPA APLYYRRASA SAASEDDAPT AVWRREDSSS
AGVADPPAWE KASVPDSQAL NLCVAGLAPS TSRGGAEDED EQPMVCMICE DKATGLHYGI
ITCEGCKGFF KRTVQNKRVY TCVADGNCEI TKAQRNRCQY CRFQKCLRQG MVLAAVREDR
MPGGRNSVGF GHVPGARCAA LLATQVKYKK HKKGPKNGQL MLRPDPGSPA AVSAAAAKSS
ALSVSKSPLD PKGAGTLVSL AGSKALSSSA SRVPPSRGGP GALMERRSLS AEQAAAMIDQ
LIECDDFEDV ATLNNMRDLL NDWEDLSRKL RQIADKIVHK LVQWTKRLPF YAEIPLAVHT
QLLAHKWHEL VVLTTAAYQA IQLPARLQRT LAALMGQPVT LVQLPSEALP LVDQMTGLAS
ELRRTRLCLE EYVCLKVVIM LSYGECLHRD QRQLEAIQER YLSALRVFTE TRFPNQGSRF
ADLLARLPEI QAAAALLLHS KMFYVPFLLN SSITR
//
