ID B7QK86_IXOSC Unreviewed; 883 AA.
AC B7QK86;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EEC19258.1, ECO:0000313|EnsemblMetazoa:ISCW013972-PA};
GN ORFNames=IscW_ISCW013972 {ECO:0000313|EMBL:EEC19258.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC19258.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC19258.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW013972-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW013972-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ABJB010210312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010224211; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010447552; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010674258; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010918270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011116347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS957735; EEC19258.1; -; Genomic_DNA.
DR RefSeq; XP_002415593.1; XM_002415548.1.
DR AlphaFoldDB; B7QK86; -.
DR STRING; 6945.B7QK86; -.
DR PaxDb; 6945-B7QK86; -.
DR EnsemblMetazoa; ISCW013972-RA; ISCW013972-PA; ISCW013972.
DR KEGG; isc:IscW_ISCW013972; -.
DR VEuPathDB; VectorBase:ISCI013972; -.
DR VEuPathDB; VectorBase:ISCP_007522; -.
DR VEuPathDB; VectorBase:ISCW013972; -.
DR HOGENOM; CLU_326343_0_0_1; -.
DR InParanoid; B7QK86; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IBA:GO_Central.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IBA:GO_Central.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR InterPro; IPR004875; DDE_SF_endonuclease_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001496; SOCS_box.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF5; SUPPRESSOR OF CYTOKINE-SIGNALING 7; 1.
DR Pfam; PF03184; DDE_1; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 462..519
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 818..859
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 82..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 883 AA; 97618 MW; EEE5936A11CE9DC4 CRC64;
MAPMESSEEL PWPRCMSWLL CLSWDEADMD SGRAELSLHV GSAQGAAAAP PPPDASMNLQ
DDLQAGRPVF FRVDLRSAAH EEGCGTPAAA GQTRAPGDEN ASDGAATKPS EERRPNREKR
SKEEPQLPLG VYMACLSLNK VGHCHPKGRC CCGSSNVTAA SSSPPTPRDV GSVKTLRSRC
SHTEASNYTL VLKPKAVKPR AAGSAQSVPS ASAGVEVERP DVASRPGSTP SQFLGSEEGD
LSLRAQRPPY SSPNSPVLFT QVQRQSSSPA TCENCQRSRS ATVESEWQQR RGERKEKPRR
RDRSERCCSE EITALSCGED ADDTAMSRPG CAAKKGSRYS LGSCLGSRGQ RAFKTGEHRR
RFSLTLPSAL LNLFRRRRGS SPSVRNSASQ TEPYLGEAVC YGAQASGSPY AVRALPPLPA
GCSSVCDRLS AASDAASTTS DESDRRSMDY AASIEKVKDC GWYWGPISGE TAERLLSQEP
DGSFVVRDSS DEHYIFSLTF KLNGLVRHVR IEHDQGGKYS KEGITVMVVT NVLGTEKLPL
LVIGKAKNLR CFNWMKKLSV GDQKVQLVVI SKTKDSRSFQ DPEQLPLWYS SSTKAWITQC
LFEDYLHRLY RVVEHQNVDN CGAHGKVEKL KAMRLEFLLP NTTSVLQQMD QGVIQNIKVL
HRALLLRHTV LCLDNEKRYS PDLLSMINMF TVAWKAVKPV SIAHCFKHAG FCASEEPVTD
DARPDHQEAE DGATALDVGE RLFADLRNRW MDIPGATTFH EFADVDTALI RNFSFGCLQK
FQSHTIVDFI ENAVEHSRSG RYLFFLHRRP ILGPMRVQLL HPVSRFKQVQ SLQHLCRTTL
RLHNTPHYYS EELADLAHPA FASHAFPATL VRDQSLEALF HQS
//
