ID B7QNJ9_IXOSC Unreviewed; 312 AA.
AC B7QNJ9;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=Carbonic anhydrase {ECO:0000256|RuleBase:RU367011};
DE EC=4.2.1.1 {ECO:0000256|RuleBase:RU367011};
GN ORFNames=IscW_ISCW015100 {ECO:0000313|EMBL:EEC20421.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC20421.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC20421.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW015100-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW015100-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Reversible hydration of carbon dioxide.
CC {ECO:0000256|RuleBase:RU367011}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:17544; EC=4.2.1.1;
CC Evidence={ECO:0000256|RuleBase:RU367011};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU367011};
CC -!- SIMILARITY: Belongs to the alpha-carbonic anhydrase family.
CC {ECO:0000256|ARBA:ARBA00010718, ECO:0000256|RuleBase:RU367011}.
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DR EMBL; ABJB010434170; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010464273; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010479507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010680331; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS979414; EEC20421.1; -; Genomic_DNA.
DR RefSeq; XP_002416504.1; XM_002416459.1.
DR AlphaFoldDB; B7QNJ9; -.
DR STRING; 6945.B7QNJ9; -.
DR PaxDb; 6945-B7QNJ9; -.
DR EnsemblMetazoa; ISCW015100-RA; ISCW015100-PA; ISCW015100.
DR KEGG; isc:IscW_ISCW015100; -.
DR VEuPathDB; VectorBase:ISCI015100; -.
DR VEuPathDB; VectorBase:ISCP_017707; -.
DR VEuPathDB; VectorBase:ISCW015100; -.
DR HOGENOM; CLU_039326_2_1_1; -.
DR InParanoid; B7QNJ9; -.
DR OMA; RFPLEIH; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004089; F:carbonate dehydratase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006730; P:one-carbon metabolic process; IBA:GO_Central.
DR CDD; cd00326; alpha_CA; 1.
DR Gene3D; 3.10.200.10; Alpha carbonic anhydrase; 1.
DR InterPro; IPR001148; CA_dom.
DR InterPro; IPR036398; CA_dom_sf.
DR InterPro; IPR023561; Carbonic_anhydrase_a-class.
DR InterPro; IPR018338; Carbonic_anhydrase_a-class_CS.
DR PANTHER; PTHR18952; CARBONIC ANHYDRASE; 1.
DR PANTHER; PTHR18952:SF141; CARBONIC ANHYDRASE; 1.
DR Pfam; PF00194; Carb_anhydrase; 1.
DR SMART; SM01057; Carb_anhydrase; 1.
DR SUPFAM; SSF51069; Carbonic anhydrase; 1.
DR PROSITE; PS00162; ALPHA_CA_1; 1.
DR PROSITE; PS51144; ALPHA_CA_2; 1.
PE 1: Evidence at protein level;
KW Lyase {ECO:0000256|RuleBase:RU367011, ECO:0000313|EMBL:EEC20421.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU367011};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7QNJ9};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU367011}.
FT DOMAIN 45..311
FT /note="Alpha-carbonic anhydrase"
FT /evidence="ECO:0000259|PROSITE:PS51144"
FT REGION 280..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 312 AA; 34387 MW; 6A7BD9B07E829653 CRC64;
MGSSCSTGTL LPAIVASPGE GQAWGAAVSR WSTAIDRGPQ VCEMPTLTVD PDTASRGPSN
WSKIYPKAAG EKQSPIDIVQ KNVQSDPFLA ENPLRWNYKG LHCTNLLNTG CGWRADVTAQ
GPNISGGPLH HNYQMVQFHS HWGTCSKMGS EHTVDGEHYA GELHLVHYNL DMYSRASEAA
CSDKGLSVIG IFLKEGQPHE ELQKITDSMK KVIYRGDKCS IDQDIDIGSL IPKNSSYWTY
EGSLTTPPCY ESVTWIVFKE PIEVSQEQFE AFRELMSYKE GEGPKAPTDG PILKNYRPPQ
PLMGRVVRDP AN
//