ID B7QP04_IXOSC Unreviewed; 394 AA.
AC B7QP04;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=Alpha tubulin, putative {ECO:0000313|EMBL:EEC20577.1, ECO:0000313|EnsemblMetazoa:ISCW015258-PA};
GN ORFNames=IscW_ISCW015258 {ECO:0000313|EMBL:EEC20577.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC20577.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC20577.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW015258-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW015258-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the tubulin family.
CC {ECO:0000256|ARBA:ARBA00009636}.
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DR EMBL; ABJB010212235; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010324746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010347088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010486070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010653201; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010854415; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010903373; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS980981; EEC20577.1; -; Genomic_DNA.
DR RefSeq; XP_002416660.1; XM_002416615.1.
DR AlphaFoldDB; B7QP04; -.
DR STRING; 6945.B7QP04; -.
DR PaxDb; 6945-B7QP04; -.
DR EnsemblMetazoa; ISCW015258-RA; ISCW015258-PA; ISCW015258.
DR KEGG; isc:IscW_ISCW015258; -.
DR VEuPathDB; VectorBase:ISCI015258; -.
DR VEuPathDB; VectorBase:ISCW015258; -.
DR HOGENOM; CLU_015718_6_0_1; -.
DR InParanoid; B7QP04; -.
DR OMA; RRVTDNC; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR CDD; cd02186; alpha_tubulin; 1.
DR Gene3D; 1.10.287.600; Helix hairpin bin; 1.
DR Gene3D; 3.30.1330.20; Tubulin/FtsZ, C-terminal domain; 1.
DR Gene3D; 3.40.50.1440; Tubulin/FtsZ, GTPase domain; 1.
DR InterPro; IPR002452; Alpha_tubulin.
DR InterPro; IPR008280; Tub_FtsZ_C.
DR InterPro; IPR000217; Tubulin.
DR InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR InterPro; IPR023123; Tubulin_C.
DR InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR PANTHER; PTHR11588; TUBULIN; 1.
DR PANTHER; PTHR11588:SF239; TUBULIN ALPHA CHAIN; 1.
DR Pfam; PF00091; Tubulin; 1.
DR Pfam; PF03953; Tubulin_C; 1.
DR PRINTS; PR01162; ALPHATUBULIN.
DR PRINTS; PR01161; TUBULIN.
DR SMART; SM00864; Tubulin; 1.
DR SMART; SM00865; Tubulin_C; 1.
DR SUPFAM; SSF55307; Tubulin C-terminal domain-like; 1.
DR SUPFAM; SSF52490; Tubulin nucleotide-binding domain-like; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 1..93
FT /note="Tubulin/FtsZ GTPase"
FT /evidence="ECO:0000259|SMART:SM00864"
FT DOMAIN 95..240
FT /note="Tubulin/FtsZ 2-layer sandwich"
FT /evidence="ECO:0000259|SMART:SM00865"
FT REGION 329..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 394 AA; 43524 MW; 538DBAB1288E215E CRC64;
MERLSVDYGK KSKLEFAIYP APQVSTAVVE PYNSILTTHT TLEHSDCAFM VDNEAIYDIC
RRNLDIERPT YTNLNRLIGQ IVSSITASLR FDGALNVDLT EFQTNLVPYP RIHFPLVTYA
PVISAEKAYH EQLTVSEITN SCFEPANQMV KCDPRHGKYM ACCLLYRGDV VPKDVNAAIA
AIKTKRSIQF VDWCPTGFKV GINYQPPTVV PGGDLAKVQR AVCMLSNTTA IAEAWARLDH
KFDLMYAKRA FVHWYVGEGM EEGEFSEARE DLAALEKDYE EVGIDSAEGA EDDARSTAPP
TGTCASASQC TWARRVCRSA MPAGSFTASS MASSPTGRCQ TTGWWAAGRT PSTPSSWPPG
RASMCPGLSS STWNPRWWTR CATDPTDSCS TRNR
//
