ID B7QP17_IXOSC Unreviewed; 602 AA.
AC B7QP17;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Methyltransferase, putative {ECO:0000313|EMBL:EEC20589.1, ECO:0000313|EnsemblMetazoa:ISCW015479-PA};
DE EC=2.1.1.143 {ECO:0000313|EMBL:EEC20589.1};
GN ORFNames=IscW_ISCW015479 {ECO:0000313|EMBL:EEC20589.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC20589.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC20589.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW015479-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW015479-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; ABJB010132050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010451209; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010596433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010923492; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS981200; EEC20589.1; -; Genomic_DNA.
DR RefSeq; XP_002416672.1; XM_002416627.1.
DR AlphaFoldDB; B7QP17; -.
DR STRING; 6945.B7QP17; -.
DR PaxDb; 6945-B7QP17; -.
DR EnsemblMetazoa; ISCW015479-RA; ISCW015479-PA; ISCW015479.
DR KEGG; isc:IscW_ISCW015479; -.
DR VEuPathDB; VectorBase:ISCI015479; -.
DR VEuPathDB; VectorBase:ISCP_018956; -.
DR VEuPathDB; VectorBase:ISCW015479; -.
DR HOGENOM; CLU_029501_4_0_1; -.
DR InParanoid; B7QP17; -.
DR OMA; FRYYHVF; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0106335; F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity; IBA:GO_Central.
DR GO; GO:0000049; F:tRNA binding; IBA:GO_Central.
DR GO; GO:0030488; P:tRNA methylation; IBA:GO_Central.
DR GO; GO:0002098; P:tRNA wobble uridine modification; IBA:GO_Central.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 2.60.120.590; Alpha-ketoglutarate-dependent dioxygenase AlkB-like; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR027450; AlkB-like.
DR InterPro; IPR037151; AlkB-like_sf.
DR InterPro; IPR013216; Methyltransf_11.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR13069:SF21; ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8; 1.
DR PANTHER; PTHR13069; UNCHARACTERIZED; 1.
DR Pfam; PF13532; 2OG-FeII_Oxy_2; 1.
DR Pfam; PF08241; Methyltransf_11; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Methyltransferase {ECO:0000313|EMBL:EEC20589.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Transferase {ECO:0000313|EMBL:EEC20589.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 188..297
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
SQ SEQUENCE 602 AA; 67231 MW; 325C06D82360BC95 CRC64;
MLEKKTGITV CDHPTRYLVL NNCGLMCGGS YESILDELGK YGDIEDIVLL PGQQFAFVAF
RDVADCVSAA AFLSTRPSRL VADGSVHPAF VDKVPEHSSC GAPFLEHPPG LRLVREAVDE
AEEALLWRLV SWDRDCRALK QREVRHFGYA FDYELQGVRK DAPLAEPIPE ECAPFLGRLV
ASGHLSGLPD QLTVTRYLPG QGIPPHVDSH GSFEDGIVCL SLGSPVVMDF RHPDGDRAAV
LLPPRSALLL HGPSRYIWTH GTASRKSDVV PRTEVPGQGL TLSPRGVRIS FTFRRIRRGD
CGCGHDLLCD SSRLTKSDRE AMRLEEEHVY QVYESIAEQF SGTRHREWPR VAAFVEALEP
GSLLLDAGCG NGKYLLGHPH VLKVGFDRSG GLAAICRSRN LEVVQADTLD VPFRSGVFDA
CLSIAVLHHL ATPERREAAV REILRLLRPG GRALIYVWAL EQAEGAPSKY LKASRNASRT
LPSGCEQTPG HLPVHANRTQ FEARDMLVPW HSKGTEEVHY RYYHLFERDE LSGLLERVSP
GCVLEEYHDQ GNWQVLPYRN GFKSDRCQHA RTCNEKPERL TSPLGRLDKR FLFVWLLFPQ
NC
//
