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Database: UniProt
Entry: B7ZBT8_HUMAN
LinkDB: B7ZBT8_HUMAN
Original site: B7ZBT8_HUMAN 
ID   B7ZBT8_HUMAN            Unreviewed;      1150 AA.
AC   B7ZBT8;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   24-JAN-2024, entry version 106.
DE   SubName: Full=Protocadherin related 15 {ECO:0000313|Ensembl:ENSP00000386693.1};
GN   Name=PCDH15 {ECO:0000313|Ensembl:ENSP00000386693.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000386693.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000386693.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000386693.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   EMBL; AC013737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC016817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC024073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC027671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL353784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL360214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL365496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL391356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; B7ZBT8; -.
DR   SMR; B7ZBT8; -.
DR   IntAct; B7ZBT8; 1.
DR   MINT; B7ZBT8; -.
DR   EPD; B7ZBT8; -.
DR   MassIVE; B7ZBT8; -.
DR   MaxQB; B7ZBT8; -.
DR   PeptideAtlas; B7ZBT8; -.
DR   ProteomicsDB; 7163; -.
DR   Antibodypedia; 27955; 115 antibodies from 20 providers.
DR   Ensembl; ENST00000409834.5; ENSP00000386693.1; ENSG00000150275.20.
DR   UCSC; uc057tif.1; human.
DR   HGNC; HGNC:14674; PCDH15.
DR   VEuPathDB; HostDB:ENSG00000150275; -.
DR   GeneTree; ENSGT00940000156675; -.
DR   HOGENOM; CLU_009081_0_0_1; -.
DR   ChiTaRS; PCDH15; human.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000150275; Expressed in left adrenal gland cortex and 95 other cell types or tissues.
DR   ExpressionAtlas; B7ZBT8; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 8.
DR   Gene3D; 2.60.40.60; Cadherins; 8.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   PANTHER; PTHR24025:SF23; CADHERIN-4; 1.
DR   PANTHER; PTHR24025; DESMOGLEIN FAMILY MEMBER; 1.
DR   Pfam; PF00028; Cadherin; 7.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 8.
DR   SUPFAM; SSF49313; Cadherin-like; 8.
DR   PROSITE; PS00232; CADHERIN_1; 2.
DR   PROSITE; PS50268; CADHERIN_2; 8.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|EPD:B7ZBT8,
KW   ECO:0007829|PeptideAtlas:B7ZBT8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        986..1008
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          8..120
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          121..227
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          228..328
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          330..430
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          431..537
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          538..646
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          648..755
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          756..870
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   REGION          1039..1058
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1118..1148
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1039..1057
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1150 AA;  127291 MW;  90DBF99EA3CB00F1 CRC64;
     MPSYQGYILE SAPVGATISD SLNLTSPLRI VALDKDIEDV PPSGVPTKDP ELHLFLNDYT
     SVFTVTQTGI TRYLTLLQPV DREEQQTYTF SITAFDGVQE SEPVIVNIQV MDANDNTPTF
     PEISYDVYVY TDMRPGDSVI QLTAVDADEG SNGEITYEIL VGAQGDFIIN KTTGLITIAP
     GVEMIVGRTY ALTVQAADNA PPAERRNSIC TVYIEVLPPN NQSPPRFPQL MYSLEISEAM
     RVGAVLLNLQ ATDREGDSIT YAIENGDPQR VFNLSETTGI LTLGKALDRE STDRYILIIT
     ASDGRPDGTS TATVNIVVTD VNDNAPVFDP YLPRNLSVVE EEANAFVGQV KATDPDAGIN
     GQVHYSLGNF NNLFRITSNG SIYTAVKLNR EVRDYYELVV VATDGAVHPR HSTLTLAIKV
     LDIDDNSPVF TNSTYTVLVE ENLPAGTTIL QIEAKDVDLG ANVSYRIRSP EVKHFFALHP
     FTGELSLLRS LDYEAFPDQE ASITFLVEAF DIYGTMPPGI ATVTVIVKDM NDYPPVFSKR
     IYKGMVAPDA VKGTPITTVY AEDADPPGLP ASRVRYRVDD VQFPYPASIF EVEEDSGRVI
     TRVNLNEEPT TIFKLVVVAF DDGEPVMSSS ATVKILVLHP GEIPRFTQEE YRPPPVSELA
     TKGTMVGVIS AAAINQSIVY SIVSGNEEDT FGINNITGVI YVNGPLDYET RTSYVLRVQA
     DSLEVVLANL RVPSKSNTAK VYIEIQDENN HPPVFQKKFY IGGVSEDARM FTSVLRVKAT
     DKDTGNYSVM AYRLIIPPIK EGKEGFVVET YTGLIKTAML FHNMRRSYFK FQVIATDDYG
     KGLSGKADVL VSVVNQLDMQ VIVSNVPPTL VEKKIEDLTE ILDRYVQEQI PGAKVVVESI
     GARRHGDAFS LEDYTKCDLT VYAIDPQTNR AIDRNELFKF LDGKLLDINK DFQPYYGEGG
     RILEIRTPEA VTSIKKRGES LGYTEGALLA LAFIIILCCI PAILVVLVSY RQFKVRQAEC
     TKTARIQAAL PAAKPAVPAP APVAAPPPPP PPPPGAHLYE ELGDSSMHKN YPWSLELILA
     RNMDKIITVM SMGMKCLNMG VAVDCYHQLD RRNMVRWLVK LRKNMRRKRK SQRKLKNQRL
     KLESLVRRKK
//
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