ID B7ZQU9_XENLA Unreviewed; 219 AA.
AC B7ZQU9;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Glucagon-1 isoform X1 {ECO:0000313|RefSeq:XP_018089460.1};
GN Name=gcg.L {ECO:0000313|RefSeq:XP_018089460.1,
GN ECO:0000313|Xenbase:XB-GENE-1000161};
GN Synonyms=gcg {ECO:0000313|RefSeq:XP_018089460.1,
GN ECO:0000313|Xenbase:XB-GENE-1000161}, gcg-A
GN {ECO:0000313|RefSeq:XP_018089460.1}, gcg1
GN {ECO:0000313|RefSeq:XP_018089460.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAI69936.1};
RN [1] {ECO:0000313|EMBL:AAI69936.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Oocytes {ECO:0000313|EMBL:AAI69936.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:XP_018089460.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018089460.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018089460.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glucagon family.
CC {ECO:0000256|ARBA:ARBA00008369}.
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DR EMBL; BC169936; AAI69936.1; -; mRNA.
DR RefSeq; XP_018089460.1; XM_018233971.2.
DR GeneID; 373686; -.
DR AGR; Xenbase:XB-GENE-1000161; -.
DR CTD; 373686; -.
DR Xenbase; XB-GENE-1000161; gcg.L.
DR OMA; MNTKRNX; -.
DR OrthoDB; 5318261at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10L.
DR Bgee; 373686; Expressed in pancreas and 6 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR Gene3D; 6.10.250.590; -; 4.
DR InterPro; IPR015550; Glucagon.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR PANTHER; PTHR11418; GLUCAGON; 1.
DR PANTHER; PTHR11418:SF0; PRO-GLUCAGON; 1.
DR Pfam; PF00123; Hormone_2; 4.
DR PIRSF; PIRSF037818; Glucagon; 1.
DR PRINTS; PR00275; GLUCAGON.
DR SMART; SM00070; GLUCA; 4.
DR PROSITE; PS00260; GLUCAGON; 3.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..219
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010492846"
FT DOMAIN 53..75
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
FT DOMAIN 97..119
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
FT DOMAIN 180..202
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
FT REGION 23..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 219 AA; 25477 MW; AFCC37C06A9BD281 CRC64;
MKSTCYMIGI LLMILQNTYQ SPVPETDANS RSVKAARNEA VDDSEQLKEV KRHSQGTFTS
DYSKYLDSRR AQDFVQWLMN TKRSGELSRR NADYERHAEG TFTSDVTQQL DEKAAKEFID
WLINGGPSKE IISRRNAEFE RHAEGTYTND VTEYLEEKAA KEFIEWLIKG KPKKIRYSRH
AEGTFTNDMT NYLEEKAAKE FVGWLIKGRP KRKDLLEEQ
//
