ID   B7ZQZ5_XENLA            Unreviewed;       182 AA.
AC   B7ZQZ5;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   RecName: Full=Gremlin {ECO:0000256|PIRNR:PIRNR037254};
GN   Name=grem1.L {ECO:0000313|Xenbase:XB-GENE-865098};
GN   Synonyms=Cktsf1b1 {ECO:0000313|EMBL:AAI69983.1}, grem1
GN   {ECO:0000313|Xenbase:XB-GENE-865098};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|EMBL:AAI69983.1};
RN   [1] {ECO:0000313|EMBL:AAI69983.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocytes {ECO:0000313|EMBL:AAI69983.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC       ECO:0000256|PIRNR:PIRNR037254}.
CC   -!- SIMILARITY: Belongs to the DAN family. {ECO:0000256|ARBA:ARBA00007872,
CC       ECO:0000256|PIRNR:PIRNR037254}.
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DR   EMBL; BC169983; AAI69983.1; -; mRNA.
DR   RefSeq; NP_001083746.1; NM_001090277.1.
DR   AlphaFoldDB; B7ZQZ5; -.
DR   SMR; B7ZQZ5; -.
DR   STRING; 8355.B7ZQZ5; -.
DR   PaxDb; 8355-B7ZQZ5; -.
DR   GeneID; 399094; -.
DR   KEGG; xla:399094; -.
DR   AGR; Xenbase:XB-GENE-865098; -.
DR   CTD; 399094; -.
DR   Xenbase; XB-GENE-865098; grem1.L.
DR   OMA; TIHEDGC; -.
DR   OrthoDB; 5347549at2759; -.
DR   Bgee; 399094; Expressed in stomach and 16 other cell types or tissues.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR004133; DAN.
DR   InterPro; IPR017159; Gremlin-1/2.
DR   PANTHER; PTHR15283; GREMLIN 1; 1.
DR   PANTHER; PTHR15283:SF3; GREMLIN-1; 1.
DR   Pfam; PF03045; DAN; 1.
DR   PIRSF; PIRSF037254; Gremlin_precursor; 1.
DR   SMART; SM00041; CT; 1.
PE   2: Evidence at transcript level;
KW   Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|PIRNR:PIRNR037254};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Secreted {ECO:0000256|PIRNR:PIRNR037254};
KW   Signal {ECO:0000256|PIRNR:PIRNR037254}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|PIRNR:PIRNR037254"
FT   CHAIN           25..182
FT                   /note="Gremlin"
FT                   /evidence="ECO:0000256|PIRNR:PIRNR037254"
FT                   /id="PRO_5010897873"
SQ   SEQUENCE   182 AA;  20374 MW;  4EF3A655FFA1B7CE CRC64;
     MNCLVYALGS LFLLSGLLLP SSEGKKKVSG SQGAIPPPDK GQPNDSEQGQ AQPGDRVRGK
     GKGQALAAEE VLESSQEALH VTERKYLKRD WCKTQPLKQT IHEDGCNSRT IINRFCYGQC
     NSFYIPRHIR REEGSFQSCS FCKPKKFTTM VVTLNCPELQ PPTKKKRITR VKQCRCISID
     LD
//