ID B7ZSS4_XENTR Unreviewed; 184 AA.
AC B7ZSS4; F6PRV5;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 1A {ECO:0000256|ARBA:ARBA00040692};
DE AltName: Full=Protein phosphatase inhibitor 1 {ECO:0000256|ARBA:ARBA00042082};
GN Name=ppp1r1a {ECO:0000313|EMBL:AAI70624.1,
GN ECO:0000313|Ensembl:ENSXETP00000009351,
GN ECO:0000313|RefSeq:NP_001015900.1,
GN ECO:0000313|Xenbase:XB-GENE-489186};
GN Synonyms=pil {ECO:0000313|RefSeq:NP_001015900.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI70624.1};
RN [1] {ECO:0000313|RefSeq:NP_001015900.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI70624.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula {ECO:0000313|EMBL:AAI70624.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSXETP00000009351}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000009351};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [4] {ECO:0000313|Ensembl:ENSXETP00000009351}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001015900.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Inhibitor of protein-phosphatase 1. This protein may be
CC important in hormonal control of glycogen metabolism. Hormones that
CC elevate intracellular cAMP increase I-1 activity in many tissues. I-1
CC activation may impose cAMP control over proteins that are not directly
CC phosphorylated by PKA. Following a rise in intracellular calcium, I-1
CC is inactivated by calcineurin (or PP2B). Does not inhibit type-2
CC phosphatases. {ECO:0000256|ARBA:ARBA00037661}.
CC -!- SUBUNIT: Interacts with PPP1R15A. {ECO:0000256|ARBA:ARBA00038671}.
CC -!- SIMILARITY: Belongs to the protein phosphatase inhibitor 1 family.
CC {ECO:0000256|ARBA:ARBA00007775}.
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DR EMBL; BC170624; AAI70624.1; -; mRNA.
DR EMBL; BC170630; AAI70630.1; -; mRNA.
DR RefSeq; NP_001015900.1; NM_001015900.2.
DR STRING; 8364.ENSXETP00000052918; -.
DR PaxDb; 8364-ENSXETP00000060335; -.
DR Ensembl; ENSXETT00000009351; ENSXETP00000009351; ENSXETG00000004297.
DR GeneID; 548654; -.
DR KEGG; xtr:548654; -.
DR AGR; Xenbase:XB-GENE-489186; -.
DR CTD; 5502; -.
DR Xenbase; XB-GENE-489186; ppp1r1a.
DR OMA; CKQGSED; -.
DR OrthoDB; 5350621at2759; -.
DR Proteomes; UP000008143; Chromosome 2.
DR Bgee; ENSXETG00000004297; Expressed in skeletal muscle tissue and 10 other cell types or tissues.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR InterPro; IPR008466; PPP1R1A/B/C.
DR PANTHER; PTHR15417:SF4; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 1A; 1.
DR PANTHER; PTHR15417; PROTEIN PHOSPHATASE INHIBITOR AND DOPAMINE- AND CAMP-REGULATED NEURONAL PHOSPHOPROTEIN; 1.
DR Pfam; PF05395; DARPP-32; 1.
PE 2: Evidence at transcript level;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein phosphatase inhibitor {ECO:0000256|ARBA:ARBA00023272};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 141..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 184 AA; 20676 MW; 6E429C406D964F48 CRC64;
MEANSPRKIQ FTVPLLEPHL DPEAAEQIRR RRPTPATLVL SSDQSSPEID EERVPNPLQK
SSLSMSPHQR KKMSRTTPTM KELQLLAEHH LCKQGSEEEK IPHLQNNLDD RPDLGCCCHG
NTASTQESHI PCSCFTQDGQ QENNSLGRRH ASQEDSLDSL VSDGNTQTCE PKKQSSRIAF
IEDK
//
