ID B7ZVS4_DANRE Unreviewed; 970 AA.
AC B7ZVS4; A0A8M9PUX5; F1QE67;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=ELKS/RAB6-interacting/CAST family member 1a {ECO:0000313|Ensembl:ENSDARP00000024145};
DE SubName: Full=ELKS/Rab6-interacting/CAST family member 1 isoform X4 {ECO:0000313|RefSeq:XP_021326161.1};
DE SubName: Full=LOC548606 protein {ECO:0000313|EMBL:AAI71689.1};
GN Name=erc1a {ECO:0000313|Ensembl:ENSDARP00000024145,
GN ECO:0000313|RefSeq:XP_021326161.1,
GN ECO:0000313|ZFIN:ZDB-GENE-091214-5};
GN Synonyms=LOC548606 {ECO:0000313|EMBL:AAI71689.1}, zgc:198416
GN {ECO:0000313|RefSeq:XP_021326161.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI71689.1};
RN [1] {ECO:0000313|EMBL:AAI71689.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000024145}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000024145};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSDARP00000024145, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000024145};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4] {ECO:0000313|Ensembl:ENSDARP00000145252}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000041168};
RG Ensembl;
RL Submitted (APR-2018) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:XP_021326161.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_021326161.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CR354611; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR384055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC171689; AAI71689.1; -; mRNA.
DR RefSeq; XP_009296282.1; XM_009298007.2.
DR RefSeq; XP_021326161.1; XM_021470486.1.
DR PaxDb; 7955-ENSDARP00000024145; -.
DR Ensembl; ENSDART00000012923; ENSDARP00000024145; ENSDARG00000009941.
DR Ensembl; ENSDART00000012923.10; ENSDARP00000024145.8; ENSDARG00000009941.13.
DR Ensembl; ENSDART00000041169; ENSDARP00000041168; ENSDARG00000009941.
DR Ensembl; ENSDART00000041169.7; ENSDARP00000041168.7; ENSDARG00000009941.13.
DR Ensembl; ENSDART00000187155; ENSDARP00000145252; ENSDARG00000009941.
DR Ensembl; ENSDART00000187155.1; ENSDARP00000145252.1; ENSDARG00000009941.13.
DR AGR; ZFIN:ZDB-GENE-091214-5; -.
DR ZFIN; ZDB-GENE-091214-5; erc1a.
DR eggNOG; KOG4809; Eukaryota.
DR HOGENOM; CLU_009304_0_0_1; -.
DR TreeFam; TF324969; -.
DR Proteomes; UP000000437; Chromosome 25.
DR Bgee; ENSDARG00000009941; Expressed in brain and 5 other cell types or tissues.
DR GO; GO:0048788; C:cytoskeleton of presynaptic active zone; IBA:GO_Central.
DR GO; GO:0098882; F:structural constituent of presynaptic active zone; IBA:GO_Central.
DR GO; GO:0048790; P:maintenance of presynaptic active zone structure; IBA:GO_Central.
DR GO; GO:0007274; P:neuromuscular synaptic transmission; IBA:GO_Central.
DR GO; GO:0048167; P:regulation of synaptic plasticity; IBA:GO_Central.
DR Gene3D; 1.10.287.1490; -; 1.
DR InterPro; IPR019323; ELKS/CAST.
DR PANTHER; PTHR18861; ELKS/RAB6-INTERACTING/CAST PROTEIN; 1.
DR PANTHER; PTHR18861:SF1; ELKS_RAB6-INTERACTING_CAST FAMILY MEMBER 1; 1.
DR Pfam; PF10174; Cast; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7ZVS4};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 737..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 934..970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 150..184
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 336..397
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 468..632
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..772
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 956..970
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 970 AA; 110392 MW; 98A9EAD5C455E5C0 CRC64;
MYGSSRSVSK MDSNHSAGRN NQSNSGRSPR LPRSPRMGHR RTNSMGGSGG GPGGSGGKTL
SMENIQSLNA AYATSGPMYM SDNEVAIGTS SDHPKTAVAT GRFGGSIPYG VRGTVTGSTP
DMAMVPAVST DSMGFGGEIH AASTVPHSLR QARDNTIMEL QAQLKEVLRE NELLRKEIEV
KESKLSSSMS SIKSFWSPEL KKERALRKDE ASKISVWKEQ YRAVQDETQH LQTTVQALQA
ELRIQRDLNQ LLQPPGEPLA CEPSEEQERQ ARELFLLRRT LEEMELRMEA QRQTLVARDD
SVKKLLEMLH SKGPSAKASE EDHERTRRLA DAEMHAHHLE NLLEQRDKEL VALREELHRR
LEGTPETTKT KALQTVIEMK DSQIGSLERG LRELEDQVMM LRSSSMLSCE ERQEEAKQME
VYRNHTKFMK NKMDQVKQDL SRKDTQLLGL QTKLETLTNQ FSDSKQHIEV LKESLTAKEQ
RAAILQTEVD ALRLRLEEKE TTLNKKSKQI QEMSEEKSTL NGEIHDLKDM LDVKERKVNV
LQKKIENLQE QLRDKEKQMS SLRERVKSLQ TDTSNTDTAL TTLEDSLAEK ERIIERLKEQ
RDREEREKAE ELDTSKKELK ELKEKVSLLQ GDLSDRETSL LDLKEHASSL ASSGLKKDSK
LKSLEIALEQ RREECSKLEN QLKKAHSAAV NAQANAEISE RISSLEADVS RHREDSAKAQ
AEVDRLLDIL RQMENEKNDK DRKISELESV ASRQMKEQSK KSGKHKEPPG KGRNVNDGPQ
QESLRQKAER IEELEEALRE SVQITAEREM VLAQEEAARN HQEKQMEELL GAMEKVKLEL
ESMKAKMSST QQSLAEKEAH LTTLRAERRR HLEEVLEMKQ EALLAAISEK DANIALLELS
SSKKKKTQEE VAQLRREKDR LVQQLKQQTQ NRMKLMADNY DDGYLKTPPD QTNHKPPKSP
DQDDEEGIWA
//
