ID B8AI33_ORYSI Unreviewed; 671 AA.
AC B8AI33;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN ORFNames=OsI_08852 {ECO:0000313|EMBL:EEC73959.1};
OS Oryza sativa subsp. indica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39946 {ECO:0000313|EMBL:EEC73959.1, ECO:0000313|Proteomes:UP000007015};
RN [1] {ECO:0000313|EMBL:EEC73959.1, ECO:0000313|Proteomes:UP000007015}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 93-11 {ECO:0000313|Proteomes:UP000007015};
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C., Chen H., Xu Z., Li H., Huang H., Zhang F., Xu H.,
RA Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W.,
RA Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L.,
RA Zheng W., Hao B., Liu S., Wang W., Yuan L., Cao M., McDermott J.,
RA Samudrala R., Wang J., Wong G.K., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
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DR EMBL; CM000127; EEC73959.1; -; Genomic_DNA.
DR AlphaFoldDB; B8AI33; -.
DR SMR; B8AI33; -.
DR STRING; 39946.B8AI33; -.
DR EnsemblPlants; BGIOSGA005662-TA; BGIOSGA005662-PA; BGIOSGA005662.
DR Gramene; BGIOSGA005662-TA; BGIOSGA005662-PA; BGIOSGA005662.
DR HOGENOM; CLU_029323_0_0_1; -.
DR OMA; ECVYPGV; -.
DR Proteomes; UP000007015; Chromosome 2.
DR GO; GO:0005798; C:Golgi-associated vesicle; IEA:EnsemblPlants.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0016485; P:protein processing; IEA:InterPro.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR041084; Ncstrn_small.
DR InterPro; IPR008710; Nicastrin.
DR PANTHER; PTHR21092; NICASTRIN; 1.
DR PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR Pfam; PF18266; Ncstrn_small; 1.
DR Pfam; PF05450; Nicastrin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000007015};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..671
FT /note="Nicastrin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002867324"
FT TRANSMEM 640..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 50..206
FT /note="Nicastrin small lobe"
FT /evidence="ECO:0000259|Pfam:PF18266"
SQ SEQUENCE 671 AA; 72107 MW; 01FA5D00FAA8B58F CRC64;
MGGGSTAPLL AAFACVFLAV FPPVASGDAA TLESVPDLVK AMYINVESFP CVRLLNHSGQ
VGCSNPGHDK VIAPIVRFGN RNDQLVQPSA VLLPLNQMTD FFLRVSNDPE LYRKIAGVLV
EANGVDNMLE FSPDRKFPQQ AFAPYSNLSH HWNPTGSGIM WNKYDFPVFL LSEESTQTLQ
NLADKNEKSA NGYLANVAEF DLVMQTTKAG THDSESCLRE QSCLPLGGQS VWTSLPPISN
SSTKHQKPII MVTASQDSAS FFRDRSLGAD SPISGLIALL TAVDALSHLH DISNLKKQLV
FAVFNGEAWG YLGSRKFLQE LDQGADSVNG ISSLLIDQVL EIGSVGKAIS QGYPLFYAHA
AGNSSISMKM VDALQSASES LGSDNVKVKP AASSNPGVPP SSLMSFLGKN SSTPGLVLED
FDSQFSNRFY HSTLDGPANV NSSSIAAAAA LIARSLYILA SADLPIDLIT LNTIKVNVSL
VEELIGCLLK CDPGLSCGIV KSFISPSNSC PSHYVGVFQD LPAGTQFPSY ADDISRFIWN
FLADRTSSLA GNSSSCTGQC HDEGEICVGA EVEGGGRCVV STTRYVPAYS TRLKFEDNVW
HVLPVNSSDP FSAADPVWTE SFWNTIGLRV YAVQATSYDW LVLLIGIIIT VASYFAVIVG
RSYISKIIKR D
//
