ID B8ATG8_ORYSI Unreviewed; 974 AA.
AC B8ATG8;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=HIRAN domain-containing protein {ECO:0000259|Pfam:PF08797};
GN ORFNames=OsI_15757 {ECO:0000313|EMBL:EEC77219.1};
OS Oryza sativa subsp. indica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39946 {ECO:0000313|EMBL:EEC77219.1, ECO:0000313|Proteomes:UP000007015};
RN [1] {ECO:0000313|EMBL:EEC77219.1, ECO:0000313|Proteomes:UP000007015}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 93-11 {ECO:0000313|Proteomes:UP000007015};
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C., Chen H., Xu Z., Li H., Huang H., Zhang F., Xu H.,
RA Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W.,
RA Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L.,
RA Zheng W., Hao B., Liu S., Wang W., Yuan L., Cao M., McDermott J.,
RA Samudrala R., Wang J., Wong G.K., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
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DR EMBL; CM000129; EEC77219.1; -; Genomic_DNA.
DR AlphaFoldDB; B8ATG8; -.
DR STRING; 39946.B8ATG8; -.
DR EnsemblPlants; BGIOSGA016329-TA; BGIOSGA016329-PA; BGIOSGA016329.
DR Gramene; BGIOSGA016329-TA; BGIOSGA016329-PA; BGIOSGA016329.
DR HOGENOM; CLU_004935_0_0_1; -.
DR OMA; VIPAPHY; -.
DR Proteomes; UP000007015; Chromosome 4.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd09122; PLDc_Tdp1_1; 1.
DR Gene3D; 3.30.70.2330; -; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR InterPro; IPR014905; HIRAN.
DR InterPro; IPR010347; Tdp1.
DR PANTHER; PTHR12415:SF3; OS04G0403400 PROTEIN; 1.
DR PANTHER; PTHR12415; TYROSYL-DNA PHOSPHODIESTERASE 1; 1.
DR Pfam; PF08797; HIRAN; 1.
DR Pfam; PF06087; Tyr-DNA_phospho; 2.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007015}.
FT DOMAIN 535..665
FT /note="HIRAN"
FT /evidence="ECO:0000259|Pfam:PF08797"
FT REGION 251..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 924..951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 924..939
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 400
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR610347-1"
FT ACT_SITE 791
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR610347-1"
FT BINDING 402
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR610347-2"
FT BINDING 793
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR610347-2"
FT SITE 819
FT /note="Interaction with DNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR610347-3"
SQ SEQUENCE 974 AA; 109195 MW; 3D01E966C052E57E CRC64;
MEAEPPPENR HDDHHPSTSG GGLGYFHLRL LCPAAPLLLL LLRSDRLYSL SLSRRRGPRL
RLLASPRRRH GRRRRALLLS TSGCALRLTH RSSSADAVRV NGRPLLRGGC PADLAVGDEV
SLLRRGTRYG FLVEKFVSCE RPKLAAAEPC GEVLVLRAES LRKRLRAISE SHDPLSFLRD
SHCVENGSDD VRVKKAREED VFLPLNLNAP IDAVAEEGLL REDCNLGQGK LEHCTDSAIA
KNETDELIQR SKGSCDGNTE QKEYSNENTE QQHNENEGCY SDGSTFFLNR LIGIGSDVKV
EQRSGVTLPQ LLHPMDSLER VFIATFSSDV SWFLDYCKVP QNLPVTIACH NKERCWSASR
ESRTAAPFGS YPNLLLVYPQ FPEEIAFGKD RKKQGVACHH PKLLVLQRKD SMRVIVTSAN
LVPRQWHLIT NTVWWQDFPC RTSTDYSALF SKVEESKSDF ATQLVSFIAF LINEVPSQSY
WINEIAKYNF EGAAGYLIAS VPGIYARNPH YLESNYCLSR KQILHTKSAH RMFLGSVQTS
VVGLSHRFHI PSDAGSKLKA LSVLLSKCHV NMHGTTEVIL KRNTNIPADA NAVSVLVADL
NKFTEEANNH VQCPEIDSVH LGFLPREVAK WVSPLSDLGF FTFSGFIYPR EALEAAYGAT
NTKVQLLLYV SKGPEFSQIS RLIQDEHFPL LCSLVASLKR SLGLWRLEEV LSHFKWPETL
ETDFFYSASS IGTSINPQFI ASFASAAGKR CNQDLDSEES DPERTWQRLR STGIFRDAIP
HPYERIGHPM HVKVAQRRFE SRLGRHSFGW TYCGSHNFSP AAWGQQLPPP KANPTEARAV
SSGPRLHICN YELGIILIIP PSAMSKQISG RRHEINDIAL PFVVPPPQYK LGDRPATSLA
MREAMAEARI LQSNDLVLDL SQDTDEDIPD EDDEHVIELS DCSPEEKEEE KIYAETLWEQ
VDSSQSQGKD QAGQ
//
