ID B8BRD8_THAPS Unreviewed; 688 AA.
AC B8BRD8;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=NADPH-dependent FMN reductase-like domain-containing protein {ECO:0000259|Pfam:PF03358};
GN ORFNames=THAPSDRAFT_20904 {ECO:0000313|EMBL:EED95941.1};
OS Thalassiosira pseudonana (Marine diatom) (Cyclotella nana).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Coscinodiscophyceae; Thalassiosirophycidae; Thalassiosirales;
OC Thalassiosiraceae; Thalassiosira.
OX NCBI_TaxID=35128 {ECO:0000313|EMBL:EED95941.1, ECO:0000313|Proteomes:UP000001449};
RN [1] {ECO:0000313|EMBL:EED95941.1, ECO:0000313|Proteomes:UP000001449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:EED95941.1};
RX PubMed=15459382; DOI=10.1126/science.1101156;
RA Armbrust E.V., Berges J.A., Bowler C., Green B.R., Martinez D.,
RA Putnam N.H., Zhou S., Allen A.E., Apt K.E., Bechner M., Brzezinski M.A.,
RA Chaal B.K., Chiovitti A., Davis A.K., Demarest M.S., Detter J.C.,
RA Glavina T., Goodstein D., Hadi M.Z., Hellsten U., Hildebrand M.,
RA Jenkins B.D., Jurka J., Kapitonov V.V., Kroger N., Lau W.W., Lane T.W.,
RA Larimer F.W., Lippmeier J.C., Lucas S., Medina M., Montsant A., Obornik M.,
RA Parker M.S., Palenik B., Pazour G.J., Richardson P.M., Rynearson T.A.,
RA Saito M.A., Schwartz D.C., Thamatrakoln K., Valentin K., Vardi A.,
RA Wilkerson F.P., Rokhsar D.S.;
RT "The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and
RT metabolism.";
RL Science 306:79-86(2004).
RN [2] {ECO:0000313|EMBL:EED95941.1, ECO:0000313|Proteomes:UP000001449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:EED95941.1};
RX PubMed=18923393; DOI=10.1038/nature07410;
RA Bowler C., Allen A.E., Badger J.H., Grimwood J., Jabbari K., Kuo A.,
RA Maheswari U., Martens C., Maumus F., Otillar R.P., Rayko E., Salamov A.,
RA Vandepoele K., Beszteri B., Gruber A., Heijde M., Katinka M., Mock T.,
RA Valentin K., Verret F., Berges J.A., Brownlee C., Cadoret J.P.,
RA Chiovitti A., Choi C.J., Coesel S., De Martino A., Detter J.C., Durkin C.,
RA Falciatore A., Fournet J., Haruta M., Huysman M.J., Jenkins B.D.,
RA Jiroutova K., Jorgensen R.E., Joubert Y., Kaplan A., Kroger N., Kroth P.G.,
RA La Roche J., Lindquist E., Lommer M., Martin-Jezequel V., Lopez P.J.,
RA Lucas S., Mangogna M., McGinnis K., Medlin L.K., Montsant A.,
RA Oudot-Le Secq M.P., Napoli C., Obornik M., Parker M.S., Petit J.L.,
RA Porcel B.M., Poulsen N., Robison M., Rychlewski L., Rynearson T.A.,
RA Schmutz J., Shapiro H., Siaut M., Stanley M., Sussman M.R., Taylor A.R.,
RA Vardi A., von Dassow P., Vyverman W., Willis A., Wyrwicz L.S.,
RA Rokhsar D.S., Weissenbach J., Armbrust E.V., Green B.R., Van de Peer Y.,
RA Grigoriev I.V.;
RT "The Phaeodactylum genome reveals the evolutionary history of diatom
RT genomes.";
RL Nature 456:239-244(2008).
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DR EMBL; CM000638; EED95941.1; -; Genomic_DNA.
DR RefSeq; XP_002286300.1; XM_002286264.1.
DR AlphaFoldDB; B8BRD8; -.
DR PaxDb; 35128-Thaps20904; -.
DR EnsemblProtists; EED95941; EED95941; THAPSDRAFT_20904.
DR GeneID; 7443144; -.
DR KEGG; tps:THAPSDRAFT_20904; -.
DR eggNOG; ENOG502S45Z; Eukaryota.
DR HOGENOM; CLU_400400_0_0_1; -.
DR InParanoid; B8BRD8; -.
DR Proteomes; UP000001449; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:UniProt.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.40.50.360; -; 1.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR InterPro; IPR005025; FMN_Rdtase-like.
DR InterPro; IPR006594; LisH.
DR PANTHER; PTHR15431; FGFR1 ONCOGENE PARTNER/LISH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR15431:SF4; PROTEIN TONNEAU 1A-RELATED; 1.
DR Pfam; PF03358; FMN_red; 1.
DR Pfam; PF16045; LisH_2; 1.
DR SMART; SM00667; LisH; 1.
DR SUPFAM; SSF52218; Flavoproteins; 1.
DR PROSITE; PS50896; LISH; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001449};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 141..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 388..467
FT /note="NADPH-dependent FMN reductase-like"
FT /evidence="ECO:0000259|Pfam:PF03358"
FT REGION 12..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 688 AA; 75806 MW; 1F4303349D5C757A CRC64;
MTCGTFFGRN CFSQTRLPPT HKSHTNTNQQ PNAPNQLIQP ISSSTQPLNK PMSFADSNNN
SEAPNGSTNS SIPGVRRRPP TAPYIASGSS PYGTYTEGDS LLRYAPYSDN HNEEGQQQQH
SAYFTERRRK PMPWYKQPQK LILAATLAWV GGVMYLANLA HAILRTHNNM MESRAMGITS
GTDNGYGEDV NVRFGMKDYA NGNSDYKNWL ENGQKKNTAN RYGMEELTDS DPKMGAAQDS
NYDEWLEYQA NNEVKYQANG MYGDTQRNSQ TVLQAAEGPS SSSSSSTSSQ QIYKTVTSDS
AVSTIDWPMK LGLPHISCTA SNGCTSSSNV TILVVYGPEY HTHISEMAWN VATGVHSALK
AHIKHHPSSP LHGHIVYGHT SNITFLDVMD ADAIIIGSPV YNGNVHPDVQ NWINYWHIDA
DLSNKFGGAF VTAGGIHAGA DGTIMSILRS MMVFQMMAVG GDSWTSPFGV AATMYEDPFG
DYQRVDDFNS SCYFTEKQGR RGDHLVHPYF LKKANGLGER ITNVTVAWKN SSYERATGES
GMAEATTAIR DALLETLQRT GTLDSIRSQL RADVYQALDE SLAVSPVSSS TEQPPLENIL
INELLADYLA FNGYNNTLSV FATETGTPSL QEAHGGVRRY ASNKKKNTSL GLDFIRNDLG
LARRHSPLAM MYEIIDVLKR RRSRDNSS
//
