ID B8BT31_THAPS Unreviewed; 908 AA.
AC B8BT31;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Tyrosine specific protein phosphatases domain-containing protein {ECO:0000259|PROSITE:PS50056};
GN ORFNames=THAPSDRAFT_1011 {ECO:0000313|EMBL:EED95648.1};
OS Thalassiosira pseudonana (Marine diatom) (Cyclotella nana).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Coscinodiscophyceae; Thalassiosirophycidae; Thalassiosirales;
OC Thalassiosiraceae; Thalassiosira.
OX NCBI_TaxID=35128 {ECO:0000313|EMBL:EED95648.1, ECO:0000313|Proteomes:UP000001449};
RN [1] {ECO:0000313|EMBL:EED95648.1, ECO:0000313|Proteomes:UP000001449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:EED95648.1};
RX PubMed=15459382; DOI=10.1126/science.1101156;
RA Armbrust E.V., Berges J.A., Bowler C., Green B.R., Martinez D.,
RA Putnam N.H., Zhou S., Allen A.E., Apt K.E., Bechner M., Brzezinski M.A.,
RA Chaal B.K., Chiovitti A., Davis A.K., Demarest M.S., Detter J.C.,
RA Glavina T., Goodstein D., Hadi M.Z., Hellsten U., Hildebrand M.,
RA Jenkins B.D., Jurka J., Kapitonov V.V., Kroger N., Lau W.W., Lane T.W.,
RA Larimer F.W., Lippmeier J.C., Lucas S., Medina M., Montsant A., Obornik M.,
RA Parker M.S., Palenik B., Pazour G.J., Richardson P.M., Rynearson T.A.,
RA Saito M.A., Schwartz D.C., Thamatrakoln K., Valentin K., Vardi A.,
RA Wilkerson F.P., Rokhsar D.S.;
RT "The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and
RT metabolism.";
RL Science 306:79-86(2004).
RN [2] {ECO:0000313|EMBL:EED95648.1, ECO:0000313|Proteomes:UP000001449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:EED95648.1};
RX PubMed=18923393; DOI=10.1038/nature07410;
RA Bowler C., Allen A.E., Badger J.H., Grimwood J., Jabbari K., Kuo A.,
RA Maheswari U., Martens C., Maumus F., Otillar R.P., Rayko E., Salamov A.,
RA Vandepoele K., Beszteri B., Gruber A., Heijde M., Katinka M., Mock T.,
RA Valentin K., Verret F., Berges J.A., Brownlee C., Cadoret J.P.,
RA Chiovitti A., Choi C.J., Coesel S., De Martino A., Detter J.C., Durkin C.,
RA Falciatore A., Fournet J., Haruta M., Huysman M.J., Jenkins B.D.,
RA Jiroutova K., Jorgensen R.E., Joubert Y., Kaplan A., Kroger N., Kroth P.G.,
RA La Roche J., Lindquist E., Lommer M., Martin-Jezequel V., Lopez P.J.,
RA Lucas S., Mangogna M., McGinnis K., Medlin L.K., Montsant A.,
RA Oudot-Le Secq M.P., Napoli C., Obornik M., Parker M.S., Petit J.L.,
RA Porcel B.M., Poulsen N., Robison M., Rychlewski L., Rynearson T.A.,
RA Schmutz J., Shapiro H., Siaut M., Stanley M., Sussman M.R., Taylor A.R.,
RA Vardi A., von Dassow P., Vyverman W., Willis A., Wyrwicz L.S.,
RA Rokhsar D.S., Weissenbach J., Armbrust E.V., Green B.R., Van de Peer Y.,
RA Grigoriev I.V.;
RT "The Phaeodactylum genome reveals the evolutionary history of diatom
RT genomes.";
RL Nature 456:239-244(2008).
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class dual specificity subfamily.
CC {ECO:0000256|ARBA:ARBA00008601}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM000638; EED95648.1; -; Genomic_DNA.
DR RefSeq; XP_002286007.1; XM_002285971.1.
DR AlphaFoldDB; B8BT31; -.
DR STRING; 35128.B8BT31; -.
DR PaxDb; 35128-Thaps1011; -.
DR EnsemblProtists; EED95648; EED95648; THAPSDRAFT_1011.
DR GeneID; 7453151; -.
DR KEGG; tps:THAPSDRAFT_1011; -.
DR eggNOG; KOG1716; Eukaryota.
DR HOGENOM; CLU_319943_0_0_1; -.
DR InParanoid; B8BT31; -.
DR OMA; NKRSEIW; -.
DR Proteomes; UP000001449; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0033550; F:MAP kinase tyrosine phosphatase activity; IBA:GO_Central.
DR GO; GO:0017017; F:MAP kinase tyrosine/serine/threonine phosphatase activity; IBA:GO_Central.
DR GO; GO:0008330; F:protein tyrosine/threonine phosphatase activity; IBA:GO_Central.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0043409; P:negative regulation of MAPK cascade; IBA:GO_Central.
DR CDD; cd14498; DSP; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR10159; DUAL SPECIFICITY PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR10159:SF537; TYROSINE-PROTEIN PHOSPHATASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00782; DSPc; 1.
DR SMART; SM00195; DSPc; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001449}.
FT DOMAIN 152..224
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 908 AA; 102114 MW; 85920E6FA6F171E2 CRC64;
MSSDAAADGN ANPTDAVFKE TELESRLTLI RQQVARPIPT QPFEDNTPAL IPFHDNVTSA
AAASGGGIII GSWRHAANIP LLKSMNVTAV LNCASGGIAR LPVDDLKENG IRYCFTNCRQ
DSHTYPILHE KKKQRRNSTD EEDASYERYI CSHHLEVSNA LYTDIRRENG NNGSTTTDGN
VLFFCVAGQN RSATLAVATL MLHGKPLEEI LAHCSKQRPF VLENVGFQRQ IVELEAILNK
LSRGASELLK DIFSTHWKQL QYSNDPTLIK QYKKVRMMDD AVDNQLLNIT DRPIPLSDVG
KTRTKSEYDL LAGTKVEIEL LIPGLCTMEV RIPVECTIQT VKRCLIKHAN DNLLRHGEQP
AKVAKAWVVL AMFGYDDMYD IPLENEAVEM KVQLERMESM FGLTHVIKDG EPQVKWNSLC
RFALVIFSVV NLPKIPSCDS SAEDKEFMDV DVDTDDDKDN SLHPDQVPWT FEHVERPGAP
ATLLQNTLRT THLRAWDFVT GAALASKLPI VFSFAEDSRD RRAFMMVSRS ANTLQQFTAP
GEGDILGMGE NAIVHRVQLS HTRADGAHRD DNWTPVNVGL QKETNAVGQS NNIVDAESSI
DDDEWDAAVK RPFSLAKMLV FLQNSSEAGL AKRLRLANLL NSDKRVLYFY GLGLGLSTNA
YDNTKYKFEL MLLAEYEEDF SAYTLRVFME EYMTVLSTVE NERERASISK LQSDFSITSI
KVLLVSLLNA FRDLTLMGVQ SFDFNHLNNV LVSRDYRHVR LIDIDGNSQG SIDYPSIESI
AKNAKNALSP RLKPPQKPCL DVDLNILLPS VIEQLMLGKG RGRMFVSNKR SEIWRAREDV
GKDMIQQILL ENFYPSADSE NEPGSKALSH TTKTAEWFYS LMKKQAPWTN WTHDIYDAMR
CIDHLPIS
//
