ID B8BWC6_THAPS Unreviewed; 2573 AA.
AC B8BWC6;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Anaphase-promoting complex subunit 5 domain-containing protein {ECO:0000259|Pfam:PF12862};
GN ORFNames=THAPSDRAFT_21997 {ECO:0000313|EMBL:EED94495.1};
OS Thalassiosira pseudonana (Marine diatom) (Cyclotella nana).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Coscinodiscophyceae; Thalassiosirophycidae; Thalassiosirales;
OC Thalassiosiraceae; Thalassiosira.
OX NCBI_TaxID=35128 {ECO:0000313|EMBL:EED94495.1, ECO:0000313|Proteomes:UP000001449};
RN [1] {ECO:0000313|EMBL:EED94495.1, ECO:0000313|Proteomes:UP000001449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:EED94495.1};
RX PubMed=15459382; DOI=10.1126/science.1101156;
RA Armbrust E.V., Berges J.A., Bowler C., Green B.R., Martinez D.,
RA Putnam N.H., Zhou S., Allen A.E., Apt K.E., Bechner M., Brzezinski M.A.,
RA Chaal B.K., Chiovitti A., Davis A.K., Demarest M.S., Detter J.C.,
RA Glavina T., Goodstein D., Hadi M.Z., Hellsten U., Hildebrand M.,
RA Jenkins B.D., Jurka J., Kapitonov V.V., Kroger N., Lau W.W., Lane T.W.,
RA Larimer F.W., Lippmeier J.C., Lucas S., Medina M., Montsant A., Obornik M.,
RA Parker M.S., Palenik B., Pazour G.J., Richardson P.M., Rynearson T.A.,
RA Saito M.A., Schwartz D.C., Thamatrakoln K., Valentin K., Vardi A.,
RA Wilkerson F.P., Rokhsar D.S.;
RT "The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and
RT metabolism.";
RL Science 306:79-86(2004).
RN [2] {ECO:0000313|EMBL:EED94495.1, ECO:0000313|Proteomes:UP000001449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:EED94495.1};
RX PubMed=18923393; DOI=10.1038/nature07410;
RA Bowler C., Allen A.E., Badger J.H., Grimwood J., Jabbari K., Kuo A.,
RA Maheswari U., Martens C., Maumus F., Otillar R.P., Rayko E., Salamov A.,
RA Vandepoele K., Beszteri B., Gruber A., Heijde M., Katinka M., Mock T.,
RA Valentin K., Verret F., Berges J.A., Brownlee C., Cadoret J.P.,
RA Chiovitti A., Choi C.J., Coesel S., De Martino A., Detter J.C., Durkin C.,
RA Falciatore A., Fournet J., Haruta M., Huysman M.J., Jenkins B.D.,
RA Jiroutova K., Jorgensen R.E., Joubert Y., Kaplan A., Kroger N., Kroth P.G.,
RA La Roche J., Lindquist E., Lommer M., Martin-Jezequel V., Lopez P.J.,
RA Lucas S., Mangogna M., McGinnis K., Medlin L.K., Montsant A.,
RA Oudot-Le Secq M.P., Napoli C., Obornik M., Parker M.S., Petit J.L.,
RA Porcel B.M., Poulsen N., Robison M., Rychlewski L., Rynearson T.A.,
RA Schmutz J., Shapiro H., Siaut M., Stanley M., Sussman M.R., Taylor A.R.,
RA Vardi A., von Dassow P., Vyverman W., Willis A., Wyrwicz L.S.,
RA Rokhsar D.S., Weissenbach J., Armbrust E.V., Green B.R., Van de Peer Y.,
RA Grigoriev I.V.;
RT "The Phaeodactylum genome reveals the evolutionary history of diatom
RT genomes.";
RL Nature 456:239-244(2008).
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DR EMBL; CM000640; EED94495.1; -; Genomic_DNA.
DR RefSeq; XP_002289059.1; XM_002289023.1.
DR PaxDb; 35128-Thaps21997; -.
DR EnsemblProtists; EED94495; EED94495; THAPSDRAFT_21997.
DR GeneID; 7452105; -.
DR KEGG; tps:THAPSDRAFT_21997; -.
DR eggNOG; KOG1840; Eukaryota.
DR HOGENOM; CLU_228034_0_0_1; -.
DR InParanoid; B8BWC6; -.
DR OMA; LAHDEMG; -.
DR Proteomes; UP000001449; Chromosome 3.
DR GO; GO:0097546; C:ciliary base; IBA:GO_Central.
DR GO; GO:0097543; C:ciliary inversin compartment; IBA:GO_Central.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 13.
DR InterPro; IPR026000; Apc5_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR45641:SF20; PUB DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45641; TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870); 1.
DR Pfam; PF12862; ANAPC5; 2.
DR Pfam; PF13424; TPR_12; 10.
DR Pfam; PF13432; TPR_16; 1.
DR SMART; SM00028; TPR; 38.
DR SUPFAM; SSF48452; TPR-like; 9.
DR PROSITE; PS50005; TPR; 14.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001449};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 686..719
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 728..761
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 903..936
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 1120..1165
FT /note="Anaphase-promoting complex subunit 5"
FT /evidence="ECO:0000259|Pfam:PF12862"
FT REPEAT 1122..1155
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1677..1710
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1889..1922
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 2014..2047
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 2098..2131
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 2224..2257
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 2266..2299
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 2307..2340
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 2319..2381
FT /note="Anaphase-promoting complex subunit 5"
FT /evidence="ECO:0000259|Pfam:PF12862"
FT REPEAT 2391..2424
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 2432..2465
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 2516..2549
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 11..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..32
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..84
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..333
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2573 AA; 288452 MW; E96865B35A098240 CRC64;
MNRLFGVWGR VSADDVVVNE NDDGHSSDED SGSEGAWEAS ADEANLSNEG STSQDDAAPD
DRNEVASPDD LVDGVEEMTK EVNHEGGRGS SALAAADTAD REASNGVSSV AHGFVDGVTS
DGDNEGSYRH RNNTNPTPEE VDDSFPKARD FLADLHSIAS EEQSSDDHNI ITNIAPEQAT
DIVTGFNDDT NYAQDEEGTI THDDSRTIAT QRTIATTATR VQPVSAAFRS AQAEQTKCLH
HEHQSIFDIL DRNFEELGNY TSDCWRRSSG RGGRKEIGYN DVKLCFVAFV VVFHLPAPPV
FANEGKYLEG TDVRDGDANN SDNDDDEGSK NEHQTKQNGN AAADTTKRRR PSVPLSVAFS
LWRKVLQIPD WNEDDDTTSL SYIRSALVLL GLLDLTAIER EDGTVSTTGR AGYRNSRSSI
ECLCIQHDIN QQYGEYMAWG EHNDSFRTVI ERHEQQWNKA VMNAAQQLGP NEYTLNMLPL
NTMRANCMQD TFDLLKDMAF VRRRIRVLGP SAAATAHVSD LDELLRLIDR RITTGGSSVE
PIDEQEGLLS AYEQMKKYCL HVTNELTKHH SADENEPPDS IAMTAGLGKA ALAKIGDVGN
ALHLLGASCG GYGFFEEEME YYKKALKLKE LSVSGKIENS VSASDTLHCM GFSLDNAGRS
DEALDCYNQA LEIRLECLGD NDLRVAETLH NKGALLCETE QSDEAMECLE EALRIRELHY
GEEHESCADT MQWMGNLLRK YGDTSEALDY FKFALRIKQT RLGSDDIDVA NTLFNTAVLL
DDLEKYDLSL IAYKEACRIR KLVLGEDNPE VADTLFCMGN VATVVERHEE ALGYFKESID
IRETLVKGDD HYTEELDDSL LFIANPSSLH PDTLFQYQKL IHCFEEALPL TKLIVGTNHS
DVCELLNRMG VIYTKLHDWD NAIGSFQGAL RVKRTVAPAD GDDIEVAVLL QKKGEAHLYK
QEFSRAKTTF DSALQIRERM EGRNSMSFAS SAYCLGVAYY YLEDYSHARL LFQECMKVQT
KLLGESDVHI ARSLCWLGRN NEQLQDPSKA LERYLSALQI CKKNKSLLDY RVVAMLLHAI
GKAYEDEKLA QPDMALRCYI EEINLIQSKL NTDDVETNKL LSEAHFNAGV LYQKDHDLDK
AIDQLKKSLE LTRQCNDADC IRVATITDQL GVMYSSQEKC DVAKGLGECL EKVGSDLALD
FFKESLRVHR LNVSEDDERV TDILFCLGRV YSDRCAYVDA ANSFEEVADT YHQLGNAQSQ
LRQYEKTLIY HRESVRINRK IEEKDALYKV SLDMAKCCEK MNNFELAIEC YNDCLRGTEE
LNDNNNIAIV LRRMGEIQMN KLHNYADAIK LFLDALELLR SEGDDGSGDE EQSILGLLPI
IGEAYALAKD YENALDFFEE HIKGVESATP VNEALVAESL YAMGVIFANM DENSDYELAI
EKLEECWNIK KELFGPDDER VADVVYTIAT VYEKEENIDK AVELLSIALR TYKMKRNKHD
TSKTYHALAK LKASSSAKSG VELDHIAALE CYEEAIKERR KVAVLDDIVL ASMLYEYATI
LCARSDYDTA MPLLEEALRI QKVKKGLKDD QVANILLRTA EVHIHNGKYD ASLVSLEQVL
FIHNALGEAV DIDLGLCHHL LSSTYLARGN YEKAVESSLE SLKWKRDEFG HNSLECASVH
NNLGKAYGKL NEFDKAIESL VEALRIRKIE LGNDSLEYGD TVLSLAELHV AMGKHSQALN
CLVEAIRVFE MFPEVDINQV VEAMEMKGDA HSSLKDYYDA AASYRECIDI YEDSSDVSAS
EEYVATLNHK LGKALASIHE YDEAFAAYRV SIKKFSSALG TDNLRVADVM HDVGLLTLGD
GAIEKAVQCF NETTRIYTLH GEQNSTKVAD TLVQLGTIHT DQSENDEAMQ VFEKAIKLYK
EKLGGDAVEI GRALLLVGRL HDIRGEYDKS MSSFTEALRT FKSSLSEDDM SISLALSNIG
IVHSRRKEYS DAVEMCIEAL RIRKIHTEND EDVADSLFNI GNIYDEWGKQ DDALPYFEGA
LKLYRLLLGD EDITVANCQQ RLGAIYWVQK KVEKSLDSFC IALSICEKVV DDVEHLLLPI
YKGLGGCYFS QEEYDKALDN FAFCLKIQKT ELGDDSIEMA TTCNIIGLIY QKKEKPLESI
NFHIKALQIY EKHRDKGSKD CIFSHIQLSK ALLASGQCDN SISRLRECLA VYSKDGDENR
EEIAAVYHQL GIAQNKLVEY EEAIDSLNKA LDIRIRVFGK ADAKVAVTLL DLGKVLQEWG
DLDEAIGVYD QAITIFQKTD CDKYTVADTY SQVAELFIEQ EKHDSSLDSL KKALKLYSSH
CGSDSYEVAK TLLQIGKEYV QLDNMEKSTG CFSEAVKILR SCDGDNDILI SQALSSLGQN
YARKKMYAKA IEMSTEALRI QKQHGDEFVS IADTLSTIGN ILDEWGKVEQ ALQFYEEALR
LYENAVGLDS VEVANCQYNV ALIEKKLGES EAALLNFGQA LRTHRTKEGD KSLGVSNDLY
QIGEIYDSFG DKEKALQCFQ ECLKIRKENF SDDHLDVLAA RRYVDTLRRR LRY
//
