ID B8C5L2_THAPS Unreviewed; 853 AA.
AC B8C5L2;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Histone deacetylase {ECO:0000313|EMBL:EED91141.1};
GN ORFNames=THAPSDRAFT_269060 {ECO:0000313|EMBL:EED91141.1};
OS Thalassiosira pseudonana (Marine diatom) (Cyclotella nana).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Coscinodiscophyceae; Thalassiosirophycidae; Thalassiosirales;
OC Thalassiosiraceae; Thalassiosira.
OX NCBI_TaxID=35128 {ECO:0000313|EMBL:EED91141.1, ECO:0000313|Proteomes:UP000001449};
RN [1] {ECO:0000313|EMBL:EED91141.1, ECO:0000313|Proteomes:UP000001449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:EED91141.1};
RX PubMed=15459382; DOI=10.1126/science.1101156;
RA Armbrust E.V., Berges J.A., Bowler C., Green B.R., Martinez D.,
RA Putnam N.H., Zhou S., Allen A.E., Apt K.E., Bechner M., Brzezinski M.A.,
RA Chaal B.K., Chiovitti A., Davis A.K., Demarest M.S., Detter J.C.,
RA Glavina T., Goodstein D., Hadi M.Z., Hellsten U., Hildebrand M.,
RA Jenkins B.D., Jurka J., Kapitonov V.V., Kroger N., Lau W.W., Lane T.W.,
RA Larimer F.W., Lippmeier J.C., Lucas S., Medina M., Montsant A., Obornik M.,
RA Parker M.S., Palenik B., Pazour G.J., Richardson P.M., Rynearson T.A.,
RA Saito M.A., Schwartz D.C., Thamatrakoln K., Valentin K., Vardi A.,
RA Wilkerson F.P., Rokhsar D.S.;
RT "The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and
RT metabolism.";
RL Science 306:79-86(2004).
RN [2] {ECO:0000313|EMBL:EED91141.1, ECO:0000313|Proteomes:UP000001449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:EED91141.1};
RX PubMed=18923393; DOI=10.1038/nature07410;
RA Bowler C., Allen A.E., Badger J.H., Grimwood J., Jabbari K., Kuo A.,
RA Maheswari U., Martens C., Maumus F., Otillar R.P., Rayko E., Salamov A.,
RA Vandepoele K., Beszteri B., Gruber A., Heijde M., Katinka M., Mock T.,
RA Valentin K., Verret F., Berges J.A., Brownlee C., Cadoret J.P.,
RA Chiovitti A., Choi C.J., Coesel S., De Martino A., Detter J.C., Durkin C.,
RA Falciatore A., Fournet J., Haruta M., Huysman M.J., Jenkins B.D.,
RA Jiroutova K., Jorgensen R.E., Joubert Y., Kaplan A., Kroger N., Kroth P.G.,
RA La Roche J., Lindquist E., Lommer M., Martin-Jezequel V., Lopez P.J.,
RA Lucas S., Mangogna M., McGinnis K., Medlin L.K., Montsant A.,
RA Oudot-Le Secq M.P., Napoli C., Obornik M., Parker M.S., Petit J.L.,
RA Porcel B.M., Poulsen N., Robison M., Rychlewski L., Rynearson T.A.,
RA Schmutz J., Shapiro H., Siaut M., Stanley M., Sussman M.R., Taylor A.R.,
RA Vardi A., von Dassow P., Vyverman W., Willis A., Wyrwicz L.S.,
RA Rokhsar D.S., Weissenbach J., Armbrust E.V., Green B.R., Van de Peer Y.,
RA Grigoriev I.V.;
RT "The Phaeodactylum genome reveals the evolutionary history of diatom
RT genomes.";
RL Nature 456:239-244(2008).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM000643; EED91141.1; -; Genomic_DNA.
DR RefSeq; XP_002291034.1; XM_002290998.1.
DR AlphaFoldDB; B8C5L2; -.
DR STRING; 35128.B8C5L2; -.
DR PaxDb; 35128-Thaps269060; -.
DR EnsemblProtists; EED91141; EED91141; THAPSDRAFT_269060.
DR GeneID; 7443596; -.
DR KEGG; tps:THAPSDRAFT_269060; -.
DR eggNOG; KOG0504; Eukaryota.
DR eggNOG; KOG1343; Eukaryota.
DR HOGENOM; CLU_334811_0_0_1; -.
DR InParanoid; B8C5L2; -.
DR OMA; EPEDYAW; -.
DR Proteomes; UP000001449; Chromosome 6.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0000118; C:histone deacetylase complex; IBA:GO_Central.
DR GO; GO:0004407; F:histone deacetylase activity; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF4; HISTONE DEACETYLASE 6, ISOFORM G; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00850; Hist_deacetyl; 1.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000001449}.
FT REPEAT 248..281
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 282..314
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 315..349
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 418..792
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 796..815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 853 AA; 92098 MW; 79270DD9E511E3C0 CRC64;
MSSDRRFSAQ QHDQETYTAA TYSSQQPSSS TAHGFGYNPG ISIRAPSQDL FQAGKFPEPS
PAACGKRKVD EIAVAQMLSG VVGGFPSASV EVSATKRPSI VSGTAAMAAS AAQDVLSSVA
EPYSTAEMFP SEDADFLAEV LGVEDARATP PPPSPPNADD VGTPPANGQT VSSGQSRGLS
LQIVNPDTLG EEETTAVSKK RLINGQASPS TPWDGQLEAL VSHVKSQEPN MDDDDFEPEG
ILQDSAFADD TAMAKSMAAK DADDICRLLI DRGADVNCRD KDGNSPIHWA ARAGHSGVLE
LLLMKNCPLD AQNDAGESAL HWAMRAGIRG MSAVQVLVES GARTNIFNRN FRRPLDVAAE
GFAGLEEEGS EAGKVVVDES ERRSIRWNLL NFSSQCRTLV LHHQECLDHM TKSQHDWEVP
DRIDSIMSSL SNRTSEQCLP SDNQNFNPCE VTVSNDFERA TLELLSRIHS AEYLAFVNDL
SKELERKRKQ QLVEDTQAES SADADGVDKP MPVVPFTPMV QRKVMKGAVV AKEPGHSDTS
FSAGSLKAAR RAAGAVQHAV DCVLVGRNRN AFCVVRPPGH HAGINGLLSN AESCGFCLFN
NVAAGAMHAL SDEKHRPRCE RCAIVDIDAH HGNGTEEIVR KCHDSGRLLF FSVHLYDHDK
PKKGNEFNYK FYPGTGAEDD VAHNVINLPS TSPHYPPHYL MGTGRLAYRR AIQHRLLPAL
RAFNPDLIIM STGFDAARGD VGNARHFVGG TEAMGFDLEP EDYAWTARKV CEVADICCNG
RVVSVLEGGY GRTAPPIPPP PMFEDAAATE GSGPVQQPLD KSLFTECAIQ HLKGLVDPYH
ADNDPDSANR KGP
//
