ID B8C5N5_THAPS Unreviewed; 1128 AA.
AC B8C5N5;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=DEAD/DEAH box helicase {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=THAPSDRAFT_262824 {ECO:0000313|EMBL:EED91151.1};
OS Thalassiosira pseudonana (Marine diatom) (Cyclotella nana).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Coscinodiscophyceae; Thalassiosirophycidae; Thalassiosirales;
OC Thalassiosiraceae; Thalassiosira.
OX NCBI_TaxID=35128 {ECO:0000313|EMBL:EED91151.1, ECO:0000313|Proteomes:UP000001449};
RN [1] {ECO:0000313|EMBL:EED91151.1, ECO:0000313|Proteomes:UP000001449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:EED91151.1};
RX PubMed=15459382; DOI=10.1126/science.1101156;
RA Armbrust E.V., Berges J.A., Bowler C., Green B.R., Martinez D.,
RA Putnam N.H., Zhou S., Allen A.E., Apt K.E., Bechner M., Brzezinski M.A.,
RA Chaal B.K., Chiovitti A., Davis A.K., Demarest M.S., Detter J.C.,
RA Glavina T., Goodstein D., Hadi M.Z., Hellsten U., Hildebrand M.,
RA Jenkins B.D., Jurka J., Kapitonov V.V., Kroger N., Lau W.W., Lane T.W.,
RA Larimer F.W., Lippmeier J.C., Lucas S., Medina M., Montsant A., Obornik M.,
RA Parker M.S., Palenik B., Pazour G.J., Richardson P.M., Rynearson T.A.,
RA Saito M.A., Schwartz D.C., Thamatrakoln K., Valentin K., Vardi A.,
RA Wilkerson F.P., Rokhsar D.S.;
RT "The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and
RT metabolism.";
RL Science 306:79-86(2004).
RN [2] {ECO:0000313|EMBL:EED91151.1, ECO:0000313|Proteomes:UP000001449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:EED91151.1};
RX PubMed=18923393; DOI=10.1038/nature07410;
RA Bowler C., Allen A.E., Badger J.H., Grimwood J., Jabbari K., Kuo A.,
RA Maheswari U., Martens C., Maumus F., Otillar R.P., Rayko E., Salamov A.,
RA Vandepoele K., Beszteri B., Gruber A., Heijde M., Katinka M., Mock T.,
RA Valentin K., Verret F., Berges J.A., Brownlee C., Cadoret J.P.,
RA Chiovitti A., Choi C.J., Coesel S., De Martino A., Detter J.C., Durkin C.,
RA Falciatore A., Fournet J., Haruta M., Huysman M.J., Jenkins B.D.,
RA Jiroutova K., Jorgensen R.E., Joubert Y., Kaplan A., Kroger N., Kroth P.G.,
RA La Roche J., Lindquist E., Lommer M., Martin-Jezequel V., Lopez P.J.,
RA Lucas S., Mangogna M., McGinnis K., Medlin L.K., Montsant A.,
RA Oudot-Le Secq M.P., Napoli C., Obornik M., Parker M.S., Petit J.L.,
RA Porcel B.M., Poulsen N., Robison M., Rychlewski L., Rynearson T.A.,
RA Schmutz J., Shapiro H., Siaut M., Stanley M., Sussman M.R., Taylor A.R.,
RA Vardi A., von Dassow P., Vyverman W., Willis A., Wyrwicz L.S.,
RA Rokhsar D.S., Weissenbach J., Armbrust E.V., Green B.R., Van de Peer Y.,
RA Grigoriev I.V.;
RT "The Phaeodactylum genome reveals the evolutionary history of diatom
RT genomes.";
RL Nature 456:239-244(2008).
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DR EMBL; CM000643; EED91151.1; -; Genomic_DNA.
DR RefSeq; XP_002291044.1; XM_002291008.1.
DR AlphaFoldDB; B8C5N5; -.
DR STRING; 35128.B8C5N5; -.
DR PaxDb; 35128-Thaps262824; -.
DR EnsemblProtists; EED91151; EED91151; THAPSDRAFT_262824.
DR GeneID; 7448620; -.
DR KEGG; tps:THAPSDRAFT_262824; -.
DR eggNOG; KOG0947; Eukaryota.
DR HOGENOM; CLU_002902_4_0_1; -.
DR InParanoid; B8C5N5; -.
DR OMA; EFHYMGQ; -.
DR Proteomes; UP000001449; Chromosome 6.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 1.10.3380.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF8; HELICASE SKI2W; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001449}.
FT DOMAIN 91..249
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 395..565
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 897..919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1088..1128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1093..1128
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1128
FT /evidence="ECO:0000313|EMBL:EED91151.1"
SQ SEQUENCE 1128 AA; 124313 MW; 4FCA94FF2E42283D CRC64;
MTRSSSTIRG QPSSPRHHLS SSPINTSRTR VHPIHYQSKS TQLFVKVDTG INEERSPSPP
SIFDDEALQE AYDTLQPHFS FPLDSWQLSA GSALLNNQNV IVCAPTGAGK TVVGEMALRI
ALERDTKAIY TTPLKALSNQ KFGEMRQVFG VDKVGLTTGD VSIRRGSDVT IMTTEVYRNM
AWKARTSNEK RDEYGDLTKN SIVVLDEFHY MGQKGRGSTW EECVITNPSH TQIVGLSATL
PNAHRLAAWM ESVTGRKTVL IEAGGQRPVP LRYYFVTKRD FSPLFHNSLF QEIGNGLPLG
LDLHPTLQKA AERRLASIDR RIQRIVDRET QDDYDSYSRG SPMSAREQRR AKEQMLKAEL
RKSVPSVAAM IGRLQDDDLL PAIFFIFSRN GCDNAAQVLC ENLGLLTFVQ TKEVAYRVLT
FNTENPEIAF SDAWVERLLL GVGSHHAGIL PAHKAFIETL FRLELMKVVF ATETLAAGIN
MPARTTVVCS MAKRGDNGMD LLETSNLLQM AGRAGRRGMD TQGACVIAAT PFEGPEEAIK
ILTDEIKPVV SQFAPSYALA INLIERGSGM LDVAKSMVQK SFGVWESQQR EKDLASAMRV
LDAYDTEASP QEQFLNALQL TLEKELSEAR EGTSPTGTSQ SKISKLEALV DVLADGKKLK
KVSKKYSGSA SLLDLEQSTL QYLEQELRTM ESANAELDLP VEFVDEDTKA MMSEIRRQRQ
RVMKGETEVN SNILSAMAKV ATNRMKDGAD GAEILRKALA AARTIDGEYS LFPDGAPLEP
GELNEYIKQS SKKNRAPMLD LTTSTSSDDY EDDSWSQMLA LTTVLEAYGC LVPLQSDAYV
GGHDNQQYEV TSGGTHVGSL GIDNSLWQVC ALGGAWDVAY KSVELDKFRD AIADFELDNE
ESHDEESDSD NDSIPKPQQE AETLTSYLLK LSSSEMAGYV STLVIDSPRQ SDSALLSFQK
LSNNQQRAVQ GALLSLERLV EVQRRLSLDD SIGRVQLELC ACDVVTAWAS GASWKEVLEM
SGSAPGDLVR TLSRALDALR QIANLPFVPA RGFEGDGVTV RLEANGVHPR IRALCRAAAN
DMDRYPVKDD LPFAVDEEDE EESESDDAEQ EEGDVAENDE EEEVGGAI
//
