ID B8CAW2_THAPS Unreviewed; 794 AA.
AC B8CAW2;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Membrane guanylyl cyclase {ECO:0000313|EMBL:EED89211.1};
GN ORFNames=THAPSDRAFT_24575 {ECO:0000313|EMBL:EED89211.1};
OS Thalassiosira pseudonana (Marine diatom) (Cyclotella nana).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Coscinodiscophyceae; Thalassiosirophycidae; Thalassiosirales;
OC Thalassiosiraceae; Thalassiosira.
OX NCBI_TaxID=35128 {ECO:0000313|EMBL:EED89211.1, ECO:0000313|Proteomes:UP000001449};
RN [1] {ECO:0000313|EMBL:EED89211.1, ECO:0000313|Proteomes:UP000001449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:EED89211.1};
RX PubMed=15459382; DOI=10.1126/science.1101156;
RA Armbrust E.V., Berges J.A., Bowler C., Green B.R., Martinez D.,
RA Putnam N.H., Zhou S., Allen A.E., Apt K.E., Bechner M., Brzezinski M.A.,
RA Chaal B.K., Chiovitti A., Davis A.K., Demarest M.S., Detter J.C.,
RA Glavina T., Goodstein D., Hadi M.Z., Hellsten U., Hildebrand M.,
RA Jenkins B.D., Jurka J., Kapitonov V.V., Kroger N., Lau W.W., Lane T.W.,
RA Larimer F.W., Lippmeier J.C., Lucas S., Medina M., Montsant A., Obornik M.,
RA Parker M.S., Palenik B., Pazour G.J., Richardson P.M., Rynearson T.A.,
RA Saito M.A., Schwartz D.C., Thamatrakoln K., Valentin K., Vardi A.,
RA Wilkerson F.P., Rokhsar D.S.;
RT "The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and
RT metabolism.";
RL Science 306:79-86(2004).
RN [2] {ECO:0000313|EMBL:EED89211.1, ECO:0000313|Proteomes:UP000001449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:EED89211.1};
RX PubMed=18923393; DOI=10.1038/nature07410;
RA Bowler C., Allen A.E., Badger J.H., Grimwood J., Jabbari K., Kuo A.,
RA Maheswari U., Martens C., Maumus F., Otillar R.P., Rayko E., Salamov A.,
RA Vandepoele K., Beszteri B., Gruber A., Heijde M., Katinka M., Mock T.,
RA Valentin K., Verret F., Berges J.A., Brownlee C., Cadoret J.P.,
RA Chiovitti A., Choi C.J., Coesel S., De Martino A., Detter J.C., Durkin C.,
RA Falciatore A., Fournet J., Haruta M., Huysman M.J., Jenkins B.D.,
RA Jiroutova K., Jorgensen R.E., Joubert Y., Kaplan A., Kroger N., Kroth P.G.,
RA La Roche J., Lindquist E., Lommer M., Martin-Jezequel V., Lopez P.J.,
RA Lucas S., Mangogna M., McGinnis K., Medlin L.K., Montsant A.,
RA Oudot-Le Secq M.P., Napoli C., Obornik M., Parker M.S., Petit J.L.,
RA Porcel B.M., Poulsen N., Robison M., Rychlewski L., Rynearson T.A.,
RA Schmutz J., Shapiro H., Siaut M., Stanley M., Sussman M.R., Taylor A.R.,
RA Vardi A., von Dassow P., Vyverman W., Willis A., Wyrwicz L.S.,
RA Rokhsar D.S., Weissenbach J., Armbrust E.V., Green B.R., Van de Peer Y.,
RA Grigoriev I.V.;
RT "The Phaeodactylum genome reveals the evolutionary history of diatom
RT genomes.";
RL Nature 456:239-244(2008).
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DR EMBL; CM000648; EED89211.1; -; Genomic_DNA.
DR RefSeq; XP_002293475.1; XM_002293439.1.
DR AlphaFoldDB; B8CAW2; -.
DR STRING; 35128.B8CAW2; -.
DR PaxDb; 35128-Thaps24575; -.
DR EnsemblProtists; EED89211; EED89211; THAPSDRAFT_24575.
DR GeneID; 7450541; -.
DR KEGG; tps:THAPSDRAFT_24575; -.
DR eggNOG; KOG4171; Eukaryota.
DR HOGENOM; CLU_353968_0_0_1; -.
DR InParanoid; B8CAW2; -.
DR OMA; ICAMSAW; -.
DR Proteomes; UP000001449; Chromosome 13.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004016; F:adenylate cyclase activity; IBA:GO_Central.
DR GO; GO:0004383; F:guanylate cyclase activity; IBA:GO_Central.
DR GO; GO:0001653; F:peptide receptor activity; IBA:GO_Central.
DR GO; GO:0006182; P:cGMP biosynthetic process; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; IBA:GO_Central.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001449};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 220..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 524..548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 583..712
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 794 AA; 88606 MW; DAA2DBB66C92F174 CRC64;
MTQFSTSITW DDEDFNRSST LGSSFQSSDD DIEVLAVGDH QPPSLDHIKQ ERRNSGIVSG
GGVFTPELSN FESIYEECAS VRSRGSKRSS SLRRLSNSVG SDLGRSVSKK MLHVRRHSSD
DRDETATVGL SSLSKSSYYS SSGSSNIWSK MLGGGSEQLW DSLNGKKGVL EDYNDYEEDD
LAKSNCLKET CALCTSSMSR CGLRWRYETR LFLRTLWKHP LILVTTLLVF GVLCGLGIFA
VEAQKDWYVE KQMNTAESVA RDTAEWFAKE FRRAMMPLYS IQQGVIHSGY FDSIRDEIEQ
LTTDSSDKRD VSGICDTSDI QQKFRDIVEP VNSENNLDGI VVGYRLFPAN VACLTEPKPN
FPPDSMASYE NTFGLDVGQT NDDMWTMITT DLFINSKDEF SIKGPGNLLP IEDAICGHLA
IWKDDPSTSV NVHGTEVPKA WGFVMNFLNW GLLKDRSNIY QRFADFDLEF ELSRVSEGAE
PTLLAESSNS KLLDDSNSVV IETETMNGVW QNRVGTVNGW EPAWYLPAII GVAVASFLFA
LLTASTLVKG ELHRNLLYKV MPRRAIAKLH RGQTVLEKFN LVTIFFSDII GFTSITGNMN
PIQVMKMLNE LYTELDKLVE KHQVYKVETV GDSYMVVGGA PDRVPAPLAA ERVALFAIDA
IELVKNFSAK DGDQIFIRAG LASGPTVAGV VGSAMPRYCF FGDTVNLAST MERTSKKMKI
QVAEITYRLL QDAPNINFQL KKRSEGVDFG DKGLQNAYWV DFAYKRDLDA KAKERLDEPM
QFVDIEANVS EYSA
//
