ID   B8CYM5_HALOH            Unreviewed;       545 AA.
AC   B8CYM5;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   SubName: Full=Glutamate synthase (NADPH) GltB2 subunit {ECO:0000313|EMBL:ACL70394.1};
DE            EC=1.4.1.13 {ECO:0000313|EMBL:ACL70394.1};
GN   OrderedLocusNames=Hore_16450 {ECO:0000313|EMBL:ACL70394.1};
OS   Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562).
OC   Bacteria; Bacillota; Clostridia; Halanaerobiales; Halothermotrichaceae;
OC   Halothermothrix.
OX   NCBI_TaxID=373903 {ECO:0000313|EMBL:ACL70394.1, ECO:0000313|Proteomes:UP000000719};
RN   [1] {ECO:0000313|EMBL:ACL70394.1, ECO:0000313|Proteomes:UP000000719}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H 168 / OCM 544 / DSM 9562 {ECO:0000313|Proteomes:UP000000719};
RX   PubMed=19145256; DOI=10.1371/journal.pone.0004192;
RA   Mavromatis K., Ivanova N., Anderson I., Lykidis A., Hooper S.D., Sun H.,
RA   Kunin V., Lapidus A., Hugenholtz P., Patel B., Kyrpides N.C.;
RT   "Genome analysis of the anaerobic thermohalophilic bacterium
RT   Halothermothrix orenii.";
RL   PLoS ONE 4:E4192-E4192(2009).
CC   -!- SIMILARITY: Belongs to the glutamate synthase family.
CC       {ECO:0000256|ARBA:ARBA00009716}.
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DR   EMBL; CP001098; ACL70394.1; -; Genomic_DNA.
DR   RefSeq; WP_012636577.1; NC_011899.1.
DR   AlphaFoldDB; B8CYM5; -.
DR   STRING; 373903.Hore_16450; -.
DR   KEGG; hor:Hore_16450; -.
DR   eggNOG; COG1304; Bacteria.
DR   HOGENOM; CLU_521509_0_0_9; -.
DR   OrthoDB; 9758182at2; -.
DR   Proteomes; UP000000719; Chromosome.
DR   GO; GO:0004355; F:glutamate synthase (NADPH) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006537; P:glutamate biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002932; Glu_synthdom.
DR   Pfam; PF01645; Glu_synthase; 1.
DR   SUPFAM; SSF51395; FMN-linked oxidoreductases; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000313|EMBL:ACL70394.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000719}.
FT   DOMAIN          292..418
FT                   /note="Glutamate synthase"
FT                   /evidence="ECO:0000259|Pfam:PF01645"
SQ   SEQUENCE   545 AA;  60015 MW;  1222CA45DA0A9072 CRC64;
     MLNWRKRNDA LGTVNRGDPA ESGLCTLCRA DCKGKCETWL SSLVGRKLLY PRDFGEITSG
     SGNISPVGVG YHSLRIQGYT HGADGLNEGL TDDADDCIFP NANVETEFGN EIETRCKVPI
     MTGALGSTFI AAKYWDSFAI GAALAGFPIV IGENVVGVDK EAVIENGKVV KAPELDRRIE
     TYQKYYNGYG AIFVQLNVED TRNGVAEYVI DKYGDDVIIE LKWGQGAKDI GGEIQVKSLE
     YAKFLADRGY VVDPDPTVEK NQQAFKNGSI KSFARHSRLG GTRAKNVDQL KEEFFNSVEF
     LRNLGFKRIS LKTGAYGMKG LAMALKFASE AKLDLLTIDG AGGGTGMSPW NMMEHWGVPS
     LLLHAKAVEY ADILSENGYE VPDMAFAGGL AREDHIFKAV AMGSPYVKLV CMGRAPMIPG
     FLGSNIEGVF YPDRKEKLNG HWDELPRTVK ELGETPESIF AGWYDVEEMV GKDEMKNIPF
     GAVALYTFVD KLKAGLQQFM AGARKFNLKE IKRSDLMSAN RETERETGIP FVTEALDEEA
     REILK
//