ID B8CZ23_HALOH Unreviewed; 322 AA.
AC B8CZ23;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Ribose-5-phosphate isomerase {ECO:0000313|EMBL:ACL70542.1};
DE EC=5.3.1.6 {ECO:0000313|EMBL:ACL70542.1};
GN OrderedLocusNames=Hore_17930 {ECO:0000313|EMBL:ACL70542.1};
OS Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562).
OC Bacteria; Bacillota; Clostridia; Halanaerobiales; Halothermotrichaceae;
OC Halothermothrix.
OX NCBI_TaxID=373903 {ECO:0000313|EMBL:ACL70542.1, ECO:0000313|Proteomes:UP000000719};
RN [1] {ECO:0000313|EMBL:ACL70542.1, ECO:0000313|Proteomes:UP000000719}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H 168 / OCM 544 / DSM 9562 {ECO:0000313|Proteomes:UP000000719};
RX PubMed=19145256; DOI=10.1371/journal.pone.0004192;
RA Mavromatis K., Ivanova N., Anderson I., Lykidis A., Hooper S.D., Sun H.,
RA Kunin V., Lapidus A., Hugenholtz P., Patel B., Kyrpides N.C.;
RT "Genome analysis of the anaerobic thermohalophilic bacterium
RT Halothermothrix orenii.";
RL PLoS ONE 4:E4192-E4192(2009).
CC -!- SIMILARITY: Belongs to the LacAB/RpiB family.
CC {ECO:0000256|ARBA:ARBA00008754}.
CC -!- SIMILARITY: Belongs to the low molecular weight phosphotyrosine protein
CC phosphatase family. {ECO:0000256|ARBA:ARBA00011063}.
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DR EMBL; CP001098; ACL70542.1; -; Genomic_DNA.
DR AlphaFoldDB; B8CZ23; -.
DR STRING; 373903.Hore_17930; -.
DR KEGG; hor:Hore_17930; -.
DR eggNOG; COG0394; Bacteria.
DR eggNOG; COG0698; Bacteria.
DR HOGENOM; CLU_059739_0_0_9; -.
DR OrthoDB; 1778624at2; -.
DR Proteomes; UP000000719; Chromosome.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0004751; F:ribose-5-phosphate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd16344; LMWPAP; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.40.1400.10; Sugar-phosphate isomerase, RpiB/LacA/LacB; 1.
DR InterPro; IPR023485; Ptyr_pPase.
DR InterPro; IPR036196; Ptyr_pPase_sf.
DR InterPro; IPR004785; RpiB.
DR InterPro; IPR003500; RpiB_LacA_LacB.
DR InterPro; IPR036569; RpiB_LacA_LacB_sf.
DR InterPro; IPR017867; Tyr_phospatase_low_mol_wt.
DR NCBIfam; TIGR01120; rpiB; 1.
DR NCBIfam; TIGR00689; rpiB_lacA_lacB; 1.
DR PANTHER; PTHR43732:SF1; RIBOSE 5-PHOSPHATE ISOMERASE; 1.
DR PANTHER; PTHR43732; RIBOSE 5-PHOSPHATE ISOMERASE-RELATED; 1.
DR Pfam; PF02502; LacAB_rpiB; 1.
DR Pfam; PF01451; LMWPc; 1.
DR PRINTS; PR00719; LMWPTPASE.
DR SMART; SM00226; LMWPc; 1.
DR SUPFAM; SSF52788; Phosphotyrosine protein phosphatases I; 1.
DR SUPFAM; SSF89623; Ribose/Galactose isomerase RpiB/AlsB; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:ACL70542.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000719}.
FT DOMAIN 2..150
FT /note="Phosphotyrosine protein phosphatase I"
FT /evidence="ECO:0000259|SMART:SM00226"
FT ACT_SITE 8
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR617867-1"
FT ACT_SITE 14
FT /evidence="ECO:0000256|PIRSR:PIRSR617867-1"
FT ACT_SITE 124
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR617867-1"
SQ SEQUENCE 322 AA; 35563 MW; FA50A41FC83E2AEE CRC64;
MPKLLFVCTG NTCRSPMARF LLEKMLSQNK DLNKKWEIDS AGIAAFPGGK ASDNAVRVLG
EEGIDLTGHL SKQVDGDLIK DVDIILTMTI NHKDMLLDNF PEAKGKVYTL KEFAGQAENP
DVSDPFGQSL EIYRQTRDEI KKYLQKIMGK LNYYNSEEGI EGMVENNIKR GDIDMKIAIG
SDHAGYEMKQ EIIKLLDELG YDVSDMGTDS DESVDYPDFA YKVASGVASG EYDRGLLVCG
TGIGMSIAAN KVEGVRAALC HDVFSARAAR NHNNANVLAL GSRVIGIGLA KEIVKTWLEA
GFDGDRHERR VNKITRIERG EY
//
