ID B8D6L4_DESA1 Unreviewed; 249 AA.
AC B8D6L4;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=DNA polymerase sliding clamp {ECO:0000256|HAMAP-Rule:MF_00317};
DE AltName: Full=Proliferating cell nuclear antigen homolog {ECO:0000256|HAMAP-Rule:MF_00317};
DE Short=PCNA {ECO:0000256|HAMAP-Rule:MF_00317};
GN Name=pcn {ECO:0000256|HAMAP-Rule:MF_00317};
GN OrderedLocusNames=DKAM_1419 {ECO:0000313|EMBL:ACL11745.1};
OS Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 /
OS 1221n) (Desulfurococcus kamchatkensis).
OC Archaea; Thermoproteota; Thermoprotei; Desulfurococcales;
OC Desulfurococcaceae; Desulfurococcus.
OX NCBI_TaxID=490899 {ECO:0000313|EMBL:ACL11745.1, ECO:0000313|Proteomes:UP000006903};
RN [1] {ECO:0000313|EMBL:ACL11745.1, ECO:0000313|Proteomes:UP000006903}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18924 / JCM 16383 / VKM B-2413 / 1221n
RC {ECO:0000313|Proteomes:UP000006903};
RX PubMed=19114480; DOI=10.1128/JB.01525-08;
RA Ravin N.V., Mardanov A.V., Beletsky A.V., Kublanov I.V., Kolganova T.V.,
RA Lebedinsky A.V., Chernyh N.A., Bonch-Osmolovskaya E.A., Skryabin K.G.;
RT "Complete genome sequence of the anaerobic, protein-degrading
RT hyperthermophilic crenarchaeon Desulfurococcus kamchatkensis.";
RL J. Bacteriol. 191:2371-2379(2009).
CC -!- FUNCTION: Sliding clamp subunit that acts as a moving platform for DNA
CC processing. Responsible for tethering the catalytic subunit of DNA
CC polymerase and other proteins to DNA during high-speed replication.
CC {ECO:0000256|HAMAP-Rule:MF_00317}.
CC -!- FUNCTION: Sliding clamp subunit. Responsible for tethering the
CC catalytic subunit of DNA polymerase to DNA during high-speed
CC replication. {ECO:0000256|RuleBase:RU003673}.
CC -!- SUBUNIT: Homotrimer. The subunits circularize to form a toroid; DNA
CC passes through its center. Replication factor C (RFC) is required to
CC load the toroid on the DNA. {ECO:0000256|HAMAP-Rule:MF_00317}.
CC -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000256|ARBA:ARBA00010462,
CC ECO:0000256|HAMAP-Rule:MF_00317, ECO:0000256|RuleBase:RU003671}.
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DR EMBL; CP001140; ACL11745.1; -; Genomic_DNA.
DR RefSeq; WP_012609086.1; NC_011766.1.
DR AlphaFoldDB; B8D6L4; -.
DR STRING; 490899.DKAM_1419; -.
DR GeneID; 7171677; -.
DR KEGG; dka:DKAM_1419; -.
DR eggNOG; arCOG00488; Archaea.
DR HOGENOM; CLU_043978_1_0_2; -.
DR Proteomes; UP000006903; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd00577; PCNA; 1.
DR Gene3D; 3.70.10.10; -; 1.
DR HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR InterPro; IPR046938; DNA_clamp_sf.
DR InterPro; IPR000730; Pr_cel_nuc_antig.
DR InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR NCBIfam; TIGR00590; pcna; 1.
DR PANTHER; PTHR11352; PROLIFERATING CELL NUCLEAR ANTIGEN; 1.
DR PANTHER; PTHR11352:SF0; PROLIFERATING CELL NUCLEAR ANTIGEN; 1.
DR Pfam; PF02747; PCNA_C; 1.
DR Pfam; PF00705; PCNA_N; 1.
DR PRINTS; PR00339; PCNACYCLIN.
DR SUPFAM; SSF55979; DNA clamp; 2.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|HAMAP-Rule:MF_00317,
KW ECO:0000256|RuleBase:RU003671};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00317}.
FT DOMAIN 3..108
FT /note="Proliferating cell nuclear antigen PCNA N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00705"
FT DOMAIN 139..246
FT /note="Proliferating cell nuclear antigen PCNA C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02747"
SQ SEQUENCE 249 AA; 27861 MW; 414510B78ACA6C3F CRC64;
MRLKFSDAVA WRYAITSISK IIDEANFRIS GEDGLLLKAM DPSTVVLVEF AIPKEAFSEY
SVERELVVGV RMDDLTKVLK RARRGDELVL EVLEDGRLSV VFEGRGVRRF TLPSIEMTYE
EIPEISFEVG FKGKLLPKLF RDIVREVEPI SDSIEFSASK DSDKLTVSSR SEIAEAEIEL
SASDGALIEY QVLSDARAKY TIDYLIDISV ASQAAELMEI EFGNGTPLKL TYEIPGGGRL
VFYVAPRED
//
