ID B8DV32_BIFA0 Unreviewed; 453 AA.
AC B8DV32;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=DNA (cytosine-5-)-methyltransferase {ECO:0000256|ARBA:ARBA00011975};
DE EC=2.1.1.37 {ECO:0000256|ARBA:ARBA00011975};
GN OrderedLocusNames=BLA_0028 {ECO:0000313|EMBL:ACL28333.1};
OS Bifidobacterium animalis subsp. lactis (strain AD011).
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Bifidobacterium.
OX NCBI_TaxID=442563 {ECO:0000313|EMBL:ACL28333.1, ECO:0000313|Proteomes:UP000002456};
RN [1] {ECO:0000313|EMBL:ACL28333.1, ECO:0000313|Proteomes:UP000002456}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AD011 {ECO:0000313|EMBL:ACL28333.1,
RC ECO:0000313|Proteomes:UP000002456};
RX PubMed=19011029; DOI=10.1128/JB.01515-08;
RA Kim J.F., Jeong H., Yu D.S., Choi S.-H., Hur C.-G., Park M.-S., Yoon S.H.,
RA Kim D.-W., Ji G.E., Park H.-S., Oh T.K.;
RT "Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp.
RT lactis AD011.";
RL J. Bacteriol. 191:678-679(2009).
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016, ECO:0000256|RuleBase:RU000416}.
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DR EMBL; CP001213; ACL28333.1; -; Genomic_DNA.
DR RefSeq; WP_004219064.1; NC_011835.1.
DR AlphaFoldDB; B8DV32; -.
DR STRING; 442563.BLA_0028; -.
DR REBASE; 19804; M.BanADORF28P.
DR GeneID; 66532405; -.
DR KEGG; bla:BLA_0028; -.
DR PATRIC; fig|442563.4.peg.28; -.
DR HOGENOM; CLU_006958_2_0_11; -.
DR Proteomes; UP000002456; Chromosome.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR031303; C5_meth_CS.
DR InterPro; IPR041657; HTH_17.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00675; dcm; 1.
DR PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10629:SF52; DNA (CYTOSINE-5)-METHYLTRANSFERASE 1; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR Pfam; PF12728; HTH_17; 1.
DR PRINTS; PR00105; C5METTRFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00095; C5_MTASE_2; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Reference proteome {ECO:0000313|Proteomes:UP000002456};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}.
FT DOMAIN 6..55
FT /note="Helix-turn-helix"
FT /evidence="ECO:0000259|Pfam:PF12728"
FT ACT_SITE 153
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 453 AA; 51155 MW; 28B0C85735995432 CRC64;
MSENALLNTK ETAQYIGVSA GVVTRLANTG ELEFDTCGAR KVFRKEAIDA YLERNNLIQA
AVDQVSTKDF EDNICALSFF SGAGGLDLGF ERAGISAALY CENNRECRMT LHRNRPDVAL
LGDITKISAD EVRRMARIPQ GREIDVMFGG PPCQAFSTAG ARRAFEDPRG NVFLRYLDLA
SELKPRYLVI ENVRGLLSTP FPVESGGKPI RGGVMRYILN KLEEMGYGVS FNLYNAANFG
AAQIRERVVI IAKRDGTKCD WLIPTHTDPD GKYVQNWNLP SWVTFRDVVY DIEDSRQTHT
DFPEKRLLYF SMLKEGQCWN KLPIEIQEEA MGKAYKLGGG KTGFYRRIAW DRPSPTLVTS
PTMPATDLCH PKELRPLSVE EYKRVQGFPD DWWIAGSIHD QYRQIGNAVP VSLGEAIGRA
ILDDMRGEAH DERWRNFPYS RYAHTSDQNW NLA
//
