ID B8EN14_METSB Unreviewed; 1094 AA.
AC B8EN14;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Acriflavin resistance protein {ECO:0000313|EMBL:ACK49149.1};
GN OrderedLocusNames=Msil_0168 {ECO:0000313|EMBL:ACK49149.1};
OS Methylocella silvestris (strain DSM 15510 / CIP 108128 / LMG 27833 / NCIMB
OS 13906 / BL2).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Beijerinckiaceae; Methylocella.
OX NCBI_TaxID=395965 {ECO:0000313|EMBL:ACK49149.1, ECO:0000313|Proteomes:UP000002257};
RN [1] {ECO:0000313|EMBL:ACK49149.1, ECO:0000313|Proteomes:UP000002257}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15510 / CIP 108128 / LMG 27833 / NCIMB 13906 / BL2
RC {ECO:0000313|Proteomes:UP000002257};
RX PubMed=20472789; DOI=10.1128/JB.00506-10;
RA Chen Y., Crombie A., Rahman M.T., Dedysh S.N., Liesack W., Stott M.B.,
RA Alam M., Theisen A.R., Murrell J.C., Dunfield P.F.;
RT "Complete genome sequence of the aerobic facultative methanotroph
RT Methylocella silvestris BL2.";
RL J. Bacteriol. 192:3840-3841(2010).
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DR EMBL; CP001280; ACK49149.1; -; Genomic_DNA.
DR RefSeq; WP_012589219.1; NC_011666.1.
DR AlphaFoldDB; B8EN14; -.
DR STRING; 395965.Msil_0168; -.
DR KEGG; msl:Msil_0168; -.
DR eggNOG; COG0841; Bacteria.
DR HOGENOM; CLU_002755_1_2_5; -.
DR OrthoDB; 9807350at2; -.
DR Proteomes; UP000002257; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 3.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF34; MULTIDRUG RESISTANCE PROTEIN MDTC; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002257};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 431..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..490
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 525..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 912..930
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 963..989
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1010..1029
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1041..1067
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1094 AA; 116032 MW; E357576C531ADD6D CRC64;
MNISAPFIRR PVATILIAAG IGLAGALGFL NLPVAPLPQV DFPTIAVSAT LPGASPETVA
SSVASPLERS LGQIAAVTEM TSRSTIGQAT ITLQFDIDRD INGAARDVQG AINAARADLP
TSLRSNPTYR KINPADAPIL LLGLTSKTKT AGQIYDIATN ILQPRLSQIE GVGQASLAGS
ALPAVRVEIN PHALSKYGIG LEDVRAALAG ANANSPKGSI EGDDRHFQIY TNDQANVAAD
YRNLVIAYRD GAPVRLSDVA EVLDSVEDLR NEGLINGKTG VLVVISPEPG ANIIRTVDTI
KAELTHLRAA MPADIDMIVT GDRSNTIRAS VQDTEQTLLF SIALVTLIVF LFLRDWRSAS
VPAVVTPLSI IGAFGAMYLA GFSLNILSLM ALTIATGFVV DDAIVVLENI ARHIEEGARP
LEAALAGARE VGFTVISISV SLIAVFIPIL FMGGIIGRLF REFALTLTFA IIISLVLSLT
LTPMMCALVL KARPVMARAS RRFDPFAALQ RGYGRTLGWA LRHSGFVMLA LFATICLNIS
LFTIIPKGFF PQVDTGRIMG SIVADQSISF QAMREKLRQL QDIVQRDPAV SSIVGFTGGS
ETNSGRCFIN LKPRAQRDVS ADEVIARLRG PLARVPGVTL YLQAVQDLRM GGRLANAQYQ
YTLQGDDANE IYRFAPKLVE ALRNSRVIAD INADQQQGGL ASQIVIDRDA AARLGVTMNE
ISQTLYDAFG QRQVSTIFSA VNQYHVVMEV APRYWQDPSI LKDIYVSPAG GNPSGSAQSA
LPSGTVTSAA NSSASASAQA ADDSARNAAT NAIASTGKSS ASAGAAVSTS KEKMIPLAAL
AHFEPGKTSL NINHQGLFVA STLSFNLRPG FSLGQGITEI NKASAQIGMP ASIRGVPQGA
AQAFQASLGN QGVLFLAALA AVYIVLGILY ESFIHPITIL STLPSAGVGA VLALLAFHLE
FSVIAMIGVI LLIGIVKKNA IMMIDFALAA ERSRGLSPRE SIFEASMLRF RPIMMTTFAA
ILGAAPLALS AGEGAELRRP LGVAIVGGLI VSQMLTLYTT PVLYLYMDRF RLAAKGRWRR
LFPRLATPST DHAS
//
