ID B8GHA0_METPE Unreviewed; 432 AA.
AC B8GHA0;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=O-acetylhomoserine/O-acetylserine sulfhydrylase {ECO:0000313|EMBL:ACL16505.1};
DE EC=2.5.1.49 {ECO:0000313|EMBL:ACL16505.1};
GN OrderedLocusNames=Mpal_1162 {ECO:0000313|EMBL:ACL16505.1};
OS Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanoregulaceae; Methanosphaerula.
OX NCBI_TaxID=521011 {ECO:0000313|EMBL:ACL16505.1, ECO:0000313|Proteomes:UP000002457};
RN [1] {ECO:0000313|EMBL:ACL16505.1, ECO:0000313|Proteomes:UP000002457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1556 / DSM 19958 / E1-9c
RC {ECO:0000313|Proteomes:UP000002457};
RX PubMed=26543115; DOI=10.1128/genomea.01280-15;
RA Cadillo-Quiroz H., Browne P., Kyrpides N., Woyke T., Goodwin L., Detter C.,
RA Yavitt J.B., Zinder S.H.;
RT "Complete Genome Sequence of Methanosphaerula palustris E1-9CT, a
RT Hydrogenotrophic Methanogen Isolated from a Minerotrophic Fen Peatland.";
RL Genome Announc. 3:e01280-15(2015).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077}.
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DR EMBL; CP001338; ACL16505.1; -; Genomic_DNA.
DR RefSeq; WP_012617824.1; NC_011832.1.
DR AlphaFoldDB; B8GHA0; -.
DR STRING; 521011.Mpal_1162; -.
DR GeneID; 7270427; -.
DR KEGG; mpl:Mpal_1162; -.
DR eggNOG; arCOG00061; Archaea.
DR HOGENOM; CLU_018986_4_0_2; -.
DR OrthoDB; 43458at2157; -.
DR Proteomes; UP000002457; Chromosome.
DR GO; GO:0003961; F:O-acetylhomoserine aminocarboxypropyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; TIGR01326; OAH_OAS_sulfhy; 1.
DR PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR PANTHER; PTHR43797:SF2; HOMOCYSTEINE_CYSTEINE SYNTHASE; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000002457};
KW Transferase {ECO:0000313|EMBL:ACL16505.1}.
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 432 AA; 47083 MW; 4A491F912AD106F2 CRC64;
MTEKKFRLGT TSLHAGQVPD PTTGSRVVPL YQTSSYVFKD TEQAENRFGL KELGNIYTRL
MNPTTDVFEK RIAAIEGGTG AIATASGAAA ITYAILNITR PGDDIVSADN LYGGTFEFFH
YTLPKFGRHV IFVDSTKPEE YKKAITPNTR ALYAETIGNP KLDTPDLEAI SKIAHDNGIP
FIVDNTTGVG LVRPIDFGVD VVVHSATKYI GGHGNSIGGV IVDSGKFAWN NGKFPEFTEP
DPGYHGLKYW DTFGNFPGLG NVAFVFKIRV SLMRDTGAVL SPFNAWLFLI GLETLHLRVP
RHSENAFAVA KFLSTHPKVA WVTYPGLPED PNHELTKKYL TGGFGPLVGV GIKGGEVASR
KFIDNLKLFS NLANIGDSKS LVIHPASTTH LQLTVEEQKK TGITPDFVRL SIGTEDIEDI
IDDLKQALEA TP
//
