ID B8GK69_METPE Unreviewed; 552 AA.
AC B8GK69;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=AMP-dependent synthetase and ligase {ECO:0000313|EMBL:ACL17140.1};
GN OrderedLocusNames=Mpal_1834 {ECO:0000313|EMBL:ACL17140.1};
OS Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanoregulaceae; Methanosphaerula.
OX NCBI_TaxID=521011 {ECO:0000313|EMBL:ACL17140.1, ECO:0000313|Proteomes:UP000002457};
RN [1] {ECO:0000313|EMBL:ACL17140.1, ECO:0000313|Proteomes:UP000002457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1556 / DSM 19958 / E1-9c
RC {ECO:0000313|Proteomes:UP000002457};
RX PubMed=26543115; DOI=10.1128/genomea.01280-15;
RA Cadillo-Quiroz H., Browne P., Kyrpides N., Woyke T., Goodwin L., Detter C.,
RA Yavitt J.B., Zinder S.H.;
RT "Complete Genome Sequence of Methanosphaerula palustris E1-9CT, a
RT Hydrogenotrophic Methanogen Isolated from a Minerotrophic Fen Peatland.";
RL Genome Announc. 3:e01280-15(2015).
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; CP001338; ACL17140.1; -; Genomic_DNA.
DR RefSeq; WP_012618459.1; NC_011832.1.
DR AlphaFoldDB; B8GK69; -.
DR STRING; 521011.Mpal_1834; -.
DR GeneID; 7270380; -.
DR KEGG; mpl:Mpal_1834; -.
DR eggNOG; arCOG04201; Archaea.
DR HOGENOM; CLU_000022_59_10_2; -.
DR OrthoDB; 193284at2157; -.
DR Proteomes; UP000002457; Chromosome.
DR GO; GO:0016878; F:acid-thiol ligase activity; IEA:UniProt.
DR GO; GO:0016405; F:CoA-ligase activity; IEA:UniProt.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43605:SF10; ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3; 1.
DR PANTHER; PTHR43605; ACYL-COENZYME A SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ACL17140.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002457}.
FT DOMAIN 32..393
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 457..535
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 552 AA; 62602 MW; 6DD8BA2C3062AA25 CRC64;
MEPVEHMEYQ EACEKFRITV PENFNFGFDV IDAWATKDRN QLAMIWTNEH GDEKKFTYRD
LKNLSNQAAN ILLKYGIKKG DRVILLLPRV PEWWIFAIAL IKLGAVFCPC PTLLTPKDLK
YRINAGKFKM IITNLENASK IEEISDQCPP LSTRFLVDGE KKGWASFQYE LLYPAPVSHR
TVSLPITRKT RASDPMLIYF TSGTTGEPKM ALHNQAYALG HEVTAALWQD IRPTDLHCTL
SDTGWAKNAW GNIFGQWIQG ACLLIFDIRG KFNATEILPL LEKYEVTTFC APPTIYRMLI
LADLDKFDLK DLRRCVSAGE PLNPEVIRVW KEGTGLPICE GYGQSETVCC IGNFPGISPR
PGSMGKPAPG WKIELHDDEG QPVPIHEEGR IAINLDPWPV GLIIEYLENP EANKDSFKNG
WYYTGDKAYM DEDGYYWFIG RDDDVIKSAG YRIGPFEVES ALLEHPSVQE CAVVGSPDMI
RGLIVKAFVI LNQGFEPSEA LVKDLQNHVK RTTAPYKYPR AIEFVSELPK TISGKIRRNE
LRRLEQERSD SS
//
