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Database: UniProt
Entry: B8HLG2_CYAP4
LinkDB: B8HLG2_CYAP4
Original site: B8HLG2_CYAP4 
ID   B8HLG2_CYAP4            Unreviewed;       354 AA.
AC   B8HLG2;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   11-DEC-2019, entry version 61.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   OrderedLocusNames=Cyan7425_4722 {ECO:0000313|EMBL:ACL47027.1};
OS   Cyanothece sp. (strain PCC 7425 / ATCC 29141).
OC   Bacteria; Cyanobacteria; Oscillatoriophycideae; Oscillatoriales;
OC   Cyanothecaceae; Cyanothece; unclassified Cyanothece.
OX   NCBI_TaxID=395961 {ECO:0000313|EMBL:ACL47027.1, ECO:0000313|Proteomes:UP000002511};
RN   [1] {ECO:0000313|Proteomes:UP000002511}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7425 / ATCC 29141 {ECO:0000313|Proteomes:UP000002511};
RX   PubMed=21972240; DOI=10.1128/mBio.00214-11;
RA   Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H.,
RA   Sherman L.A., Pakrasi H.B.;
RT   "Novel metabolic attributes of the genus Cyanothece, comprising a group of
RT   unicellular nitrogen-fixing Cyanobacteria.";
RL   MBio 2:E214-E214(2011).
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP) and
CC       D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-
CC       heptulosonate-7-phosphate (DAHP). {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702; EC=2.5.1.54;
CC         Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; CP001344; ACL47027.1; -; Genomic_DNA.
DR   RefSeq; WP_012630069.1; NC_011884.1.
DR   STRING; 395961.Cyan7425_4722; -.
DR   EnsemblBacteria; ACL47027; ACL47027; Cyan7425_4722.
DR   KEGG; cyn:Cyan7425_4722; -.
DR   eggNOG; ENOG4105E99; Bacteria.
DR   eggNOG; COG0722; LUCA.
DR   HOGENOM; HOG000220501; -.
DR   KO; K01626; -.
DR   OMA; YDINTGL; -.
DR   OrthoDB; 853329at2; -.
DR   BioCyc; CSP395961:GJDE-4488-MONOMER; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000002511; Chromosome.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002511};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361, ECO:0000256|SAAS:SAAS00080156,
KW   ECO:0000313|EMBL:ACL47027.1}.
FT   DOMAIN          43..338
FT                   /note="DAHP_synth_1"
FT                   /evidence="ECO:0000259|Pfam:PF00793"
SQ   SEQUENCE   354 AA;  38746 MW;  9B835F134A0F97AD CRC64;
     MRRTHDLHVV ETRPLSTPAS VLAQLPLSET AATLVAETRD RIRAILHSED HRLLVVVGPC
     SIHDVNAAVE YGEKLLHLRR ELAEELEIVM RVYFEKPRTS VGWKGLINDP HLDNSYDINY
     GLSLARKLLL DLTDLGLPTA TELLDPIIPQ YIADLISWTA IGARTTESQT HRQMASGLSM
     PVGFKNGTDG SVHVAVNAIL AARQQHHFLG INSAGLASII STTGNPDCHL VLRGGKEGPN
     YSATHVKAAA SELLRHGVIP RLMVDCSHDN AARDHNRQVN VLADLAEQVR QGSPHLLGIM
     IESHLVGGKQ SLPVDDRQLV YGQSITDACV DFATTTEMLR SLAVAVRESR LCLR
//
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