ID B8ICD8_METNO Unreviewed; 2668 AA.
AC B8ICD8;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=glycerophosphodiester phosphodiesterase {ECO:0000256|ARBA:ARBA00012247};
DE EC=3.1.4.46 {ECO:0000256|ARBA:ARBA00012247};
GN OrderedLocusNames=Mnod_0484 {ECO:0000313|EMBL:ACL55526.1};
OS Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Methylobacteriaceae; Methylobacterium.
OX NCBI_TaxID=460265 {ECO:0000313|EMBL:ACL55526.1, ECO:0000313|Proteomes:UP000008207};
RN [1] {ECO:0000313|EMBL:ACL55526.1, ECO:0000313|Proteomes:UP000008207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 21967 / CNCM I-2342 / ORS 2060
RC {ECO:0000313|Proteomes:UP000008207};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Marx C.J.,
RA Richardson P.;
RT "Complete sequence of chromosome of Methylobacterium nodulans ORS 2060.";
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a sn-glycero-3-phosphodiester + H2O = an alcohol + H(+) + sn-
CC glycerol 3-phosphate; Xref=Rhea:RHEA:12969, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30879, ChEBI:CHEBI:57597,
CC ChEBI:CHEBI:83408; EC=3.1.4.46;
CC Evidence={ECO:0000256|ARBA:ARBA00029315};
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DR EMBL; CP001349; ACL55526.1; -; Genomic_DNA.
DR STRING; 460265.Mnod_0484; -.
DR KEGG; mno:Mnod_0484; -.
DR eggNOG; COG0584; Bacteria.
DR eggNOG; COG1409; Bacteria.
DR eggNOG; COG2931; Bacteria.
DR HOGENOM; CLU_227504_0_0_5; -.
DR OrthoDB; 8229716at2; -.
DR Proteomes; UP000008207; Chromosome.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR Gene3D; 2.150.10.10; Serralysin-like metalloprotease, C-terminal; 4.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR030395; GP_PDE_dom.
DR InterPro; IPR018511; Hemolysin-typ_Ca-bd_CS.
DR InterPro; IPR001343; Hemolysn_Ca-bd.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR011049; Serralysin-like_metalloprot_C.
DR PANTHER; PTHR43620:SF7; GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE GDPD6; 1.
DR PANTHER; PTHR43620; GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE; 1.
DR Pfam; PF03009; GDPD; 1.
DR Pfam; PF00353; HemolysinCabind; 5.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF00149; Metallophos; 1.
DR PRINTS; PR00313; CABNDNGRPT.
DR SUPFAM; SSF51120; beta-Roll; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 4.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS51704; GP_PDE; 1.
DR PROSITE; PS00330; HEMOLYSIN_CALCIUM; 3.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000008207};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 247..603
FT /note="GP-PDE"
FT /evidence="ECO:0000259|PROSITE:PS51704"
FT REGION 2351..2373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2668 AA; 280082 MW; 3BB237CB23AFDC20 CRC64;
MSTTTPANAV EASTDWMLGI VKAAPNQTLR VAPGGTGTAS AYTLVYDVYV PAANAGGWLP
FLQTDSANSN DGDLFGKIEA GSYGIGIGGD YKGSAKLDAW NRIAFTVETQ NGEVAIGKYI
NGELVGSQTS TSTDRYAIDR SKGFLIFSDE DGETSAGYLG SFLFADRALS TDEVKALGGA
SKEGVSKAAI AGASQFDFTD GTLNATFGTA TLQATGLTPT FGTPATLGIP AMPDASEVLT
PGRANDFLVI AHRGAQAYRP EHTLEAYKLA IDMGADFIEP DLVSTKDGVL VARHDPWLAS
VKLDAAGTIA RDANGKPIVT SQTTNVADIA KFADKLTVKD YAGGKVAGWF VSDFTLAEIK
ELRAREDQPQ LRPGSASYDN QFQIPTLAEI IALVKQTEAD TGLTIGIYPE TKDPTFHKIQ
GLDTSKMLID ALKEAGFIDP SRVFIQSFEF ANLIELKTKI MPAAGVNLPL VQLVYFQAPY
VPDDVAYNFS GAPGADPSVY NVLGLNLSAT STYEAFTTPQ ALKTIANLYA SGLGPDMPFV
IDAATGAPKQ LLLDVHAAGL KVHPYTHRDD AFGANSKSFI DALTKAGVDG VFTDNTDTVV
NAVLAAQPVQ DAAGTFTGVP SLGGDPGVLH VPAPAKKTDG FVFDPAIDGT ATTYTMIFDV
LVKTGDFAGD WNALFQTNLT NGDDAKFFMK KDGATFGIGK GDYHGSATLD TWHRIAVTLT
ANGDGTSTMR KYIDGVEVGS SAYATADYTI DDKGVLLFAD NDGEGVPSHL NSFYFTDRAM
TGDEIKALGG SKVGGVLAAA PAQGRATQFD FANGTLAASF GSGTMAAAAT VVPPEPAADK
QAVVFGTPES LGLPALPGGQ DGVISAPSFD PDHGLELKPG FAPKNGSATF DTYTIVYDLY
LPKQTGLGSI FQSDLSSRSD GDLWLGFRDD QAVLGTDSQD EGRITLDAWH RLAFSIERIS
SDSFTLKKYV DGVKIGQQTV KNDFVIGDKG FLLFADDSNE TPKFSLSSVA FMEKTLSESE
VAALGGASAG GPFTAPIAGV NGVQFDFSKG EFSPSFGSGT LTARAPGVVE PPPPASVRVG
APIKDMLVTP TAANTVIDLA GVFAGNNLTY KVETAEGRVV NASVADGKLT LDFGGLGHSD
VRVTATDAAG NTAADAFRVR VAGPNAYTIA VLPDTQDYTD QNTANGPPET FYRMTEWLAA
HKDARKIQFV AHVGDVTQNN LPTEWVVAEK AMRTLDGKIP YSLLPGNHDQ ANGGTAANHS
SVNLDTLFSP EKQAATNPNT FRGVYDQEPT SSRNNYHTFT APDGTKWLIL SMEFGPRDDV
IRWASEVLDK HLDHRVMIIS HSLTDFASRH DAAGLGLYDE GTGADYGLRN DPQSVNDGET
VYRLLSAKYP NISFTFSGHI FGDGAETNVS YSQHGNPVYE MLVNYQNGIS REITGNGNEA
LGNRGGNGAI RLVTIDPDNR TLSTETYFTE FDDYLDGYRV KPELDRNGLT GSYRGHQEEF
GNVELGAPEL RAVAKAGDDL YLSAPAGADR LAVTLNASRT LDPAHDIASY VWRNADGDVI
ARGAKPTVDL AVGRHPLTLE VTDAKGHVTT DQKLVVVKGD ATLLVENFND GNAYGWVKPP
VPVKTLSTGT PAEFGLPALP GGEKKVAFVP ALPSNEGLRV TPNLGAPAGT RIASYSVIFD
ILVPPGQGDW TSLMQTDVAN KSDGDLFIRS NGNGTGGIGI SSNYTGSLQY GAWQRVAFTF
KEEADGTVTL NKFIEGVKVG SQSVSGDRFK LDVSQGALFF SDEDGEVSKL YVSSLLITDK
VYTEAEIAAL GGAKAGGIVA SAPTPLSVQF DFNDAGLRPS FGPAEMSFGS LDNTGSSGNF
VVKGSVFARP TAAEGQAAPE ARLYDQSDAK GNLLLWGDAT AKSWSDYAFE ATLQSTDNDA
IGLVFSYQDA QNHYRLTFNG KTNRRELVKV KDGVETVLAS AAKGQPFQTD MAVKVAVLDG
KISAFLNGSS IFDGVVKDAT DPLKGGTVGL YSSEQRSSMF DDLVVTKVKA LAHAGADQRA
IDFDGDGLAS VRLDAGASLG LADIVSYRWT DANGDEVATG IEPEVKLGLG SNALTLTVTD
ANGATATDRV DIDVMAKSQV LLNESFGSAE ALAKWRILDE GESGGVGPDG KSSQWELRDG
RLVQLSDLQS RQLEWQGGAT APNLWTRGWS PLGDGVNVLR RGTQAIYDDP AAKEWTDYSV
EATIKTLDND ALGFLIHYVD AKNYYKVELD AEGNYDRKAG NGAGSLFQIT RVRDGVEEVL
YQVPAKYEPG TEMRLRVDVI GGKISAFLDG EAIFAYPIED HAHPKGTVAL YSWGSEGVSF
DDVRVIAPGE AAPGNLQLSG GEGDDSLTGS AGNDTIRGGA GNDTLKGFAG ADQLFGQNGN
DTVWGGAGND FVSGGFGADS VSGDAGDDLV FSDDDDDVAD GGAGNDRVYG GTGADLVFGA
AGDDQVYGEW GNDFVSGGEG HDFVSGGFGN DEVNGDAGND LLFGDDGDDA VSGGEGDDRV
YGGTGNDLVS GEAGADQVFG EQGEDVLLGG AGSDYLSGGA GADQLFGGEG ADLLFGNAGA
DALTGGLGSD AFAFGRGDGQ DVIRDFVTGG AERDVIAFNN GAFGSFAAVQ AALRQEGSDA
VIAYGTGDTI TLQNVQATSL TAQNFTFA
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