ID   B8IDA2_METNO            Unreviewed;      1043 AA.
AC   B8IDA2;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 79.
DE   SubName: Full=Adenylate/guanylate cyclase {ECO:0000313|EMBL:ACL61268.1};
GN   OrderedLocusNames=Mnod_6499 {ECO:0000313|EMBL:ACL61268.1};
OS   Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=460265 {ECO:0000313|EMBL:ACL61268.1, ECO:0000313|Proteomes:UP000008207};
RN   [1] {ECO:0000313|EMBL:ACL61268.1, ECO:0000313|Proteomes:UP000008207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 21967 / CNCM I-2342 / ORS 2060
RC   {ECO:0000313|Proteomes:UP000008207};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Marx C.J.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium nodulans ORS 2060.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP001349; ACL61268.1; -; Genomic_DNA.
DR   AlphaFoldDB; B8IDA2; -.
DR   STRING; 460265.Mnod_6499; -.
DR   KEGG; mno:Mnod_6499; -.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG3899; Bacteria.
DR   eggNOG; COG3903; Bacteria.
DR   HOGENOM; CLU_004435_3_1_5; -.
DR   OrthoDB; 9785312at2; -.
DR   Proteomes; UP000008207; Chromosome.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR16305:SF28; ADENYLATE CYCLASE 10; 1.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008207}.
FT   DOMAIN          33..161
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1043 AA;  112426 MW;  D3FDE02C1F05511A CRC64;
     MAILDHTGRR DPPHPDRLAE NPAPSAPERR QLTVMFCDLV DSTVLASRLD PEDLRDVLRS
     YQGLCAEVVA RHGGFVAQFQ GDGIVIYFGF PMAHEDSVEA AVRAGLEILR RVPELRVSTE
     TDAQVRIGVA TGVVVVEDAT ETPGTRTAII GQVPNLAARI QAAAAPGTLV IADASRRLLG
     SLFDLTDLGP HRLKGIADEV VLWRVDGARE HAARSEGRRS GAVHVGRLRE LEALSESWAL
     AESGQGQVVL VRGEPGIGKS ALLRAWTSRL GDAPAGALAG PDVTRVALQC SPRHTHSPWY
     PLLAHLRRVS GLAPDDPPAL RREKIERLLA PERRDEGVPL LAHLLSVPLE DAPPDPDLTS
     DQRKAATLRL LLDELIGLTA RRPVVMVVED AQWADPTTEE LARLVIDRLA GRRLLLLVTA
     RPEYQPAWAD RPAVRQLTLT GLDAGEAEEL VRGLAQSRPL AAQERRDIVA KADGVPLFIE
     ELTHAVLEVR DGPGSGPEVS RVPSTLQDII MARLDRLGSA KPIAQIGAAL GRSFTWTMLQ
     RIAERPDRDL AAALGEIVQA GLLSEQSGAA GTTYLFKHAL VQDAAYESLL RASRRTLHAR
     IAAVLEADFP DIAETEPETV AHHLRGAQLF HRAAAASLRA GQRAAARFAN PEAIQHFRAG
     IEDLARVRGE ETGLLGPRLH LGLAQAFYVV KGPAHDDTVA AYARAQEFLD DLSDPDERFS
     LLWGIFSGHH FAARFAPAEA SARKCLDLAR RDGDSTHLCQ AHRMLGYVCF FRGDLPGAQA
     HFREIRRLYR PDPHRGLAPI FGADCQVGAA GFECVILCAE GRVVEAVAMA EANLYHARLL
     GHPASIGWAL ASACYVHHYR GDRPATRAAA AEGVAFCRAH AIAAWGLHCK VFLAWSAAAG
     PERADLAAEI VGDIADAATR TRLGLPQLRG LAAEALLLCG DPEPALDQVR IALDEIAQTG
     QAFFGPALLR LRGLCALARG ETDAEAWLRK AVAAARAMGA GLLEERARAD LAALAQQAGR
     RTRRELVRAL LAAPDPAGPP RRP
//