ID B8IHU6_METNO Unreviewed; 416 AA.
AC B8IHU6;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Efflux transporter, RND family, MFP subunit {ECO:0000313|EMBL:ACL55984.1};
GN OrderedLocusNames=Mnod_0971 {ECO:0000313|EMBL:ACL55984.1};
OS Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Methylobacteriaceae; Methylobacterium.
OX NCBI_TaxID=460265 {ECO:0000313|EMBL:ACL55984.1, ECO:0000313|Proteomes:UP000008207};
RN [1] {ECO:0000313|EMBL:ACL55984.1, ECO:0000313|Proteomes:UP000008207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 21967 / CNCM I-2342 / ORS 2060
RC {ECO:0000313|Proteomes:UP000008207};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Marx C.J.,
RA Richardson P.;
RT "Complete sequence of chromosome of Methylobacterium nodulans ORS 2060.";
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; CP001349; ACL55984.1; -; Genomic_DNA.
DR AlphaFoldDB; B8IHU6; -.
DR STRING; 460265.Mnod_0971; -.
DR KEGG; mno:Mnod_0971; -.
DR eggNOG; COG0845; Bacteria.
DR HOGENOM; CLU_018816_2_0_5; -.
DR Proteomes; UP000008207; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR PANTHER; PTHR30469:SF36; SLL0180 PROTEIN; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008207};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 92..310
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 133..196
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 416 AA; 44059 MW; D04261607FA448F7 CRC64;
MRRPAAPQED HARAMTGGQG GSPRGSRRGW MILALLVLAG AGGTYAWQRE RAATPPAREV
KAPAPVPVAL ARVERGPFPV VLGSLGTAQA YNTVQVRSRV DGEILRVAFK EGQVVHKGDL
LVQVDPRPFQ ATLDQAKAKK AQDEANLRNA KADLERYTKL GAYASRQQTE TQAALVAQLT
AQVASDQAAI DNAETQLGYT TIRAPLDGVT GFRQVDLGNI VNASTQTGIV TITQVEPISV
VYTSPEEELQ PIAKAFAAGP VPVEAWTSDG QTKLSEGTLS VINNQVDTAT GTIRLKATFA
NADHALWPGL SVSTRMRVGV VQDAVTIPDD AVQHGPKGLY AFVVDDAHRA HQQAIAVGPS
HAGRTLVRTG LSPGQIVIGQ GQSRVQDGSL VAENRPAEPG QAWLEEQART ATAEAP
//
