ID B8IJY4_METNO Unreviewed; 385 AA.
AC B8IJY4;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Efflux transporter, RND family, MFP subunit {ECO:0000313|EMBL:ACL59997.1};
GN OrderedLocusNames=Mnod_5151 {ECO:0000313|EMBL:ACL59997.1};
OS Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Methylobacteriaceae; Methylobacterium.
OX NCBI_TaxID=460265 {ECO:0000313|EMBL:ACL59997.1, ECO:0000313|Proteomes:UP000008207};
RN [1] {ECO:0000313|EMBL:ACL59997.1, ECO:0000313|Proteomes:UP000008207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 21967 / CNCM I-2342 / ORS 2060
RC {ECO:0000313|Proteomes:UP000008207};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Marx C.J.,
RA Richardson P.;
RT "Complete sequence of chromosome of Methylobacterium nodulans ORS 2060.";
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004519}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004519}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; CP001349; ACL59997.1; -; Genomic_DNA.
DR RefSeq; WP_015931615.1; NC_011894.1.
DR AlphaFoldDB; B8IJY4; -.
DR STRING; 460265.Mnod_5151; -.
DR KEGG; mno:Mnod_5151; -.
DR eggNOG; COG0845; Bacteria.
DR HOGENOM; CLU_018816_2_1_5; -.
DR OrthoDB; 9816569at2; -.
DR Proteomes; UP000008207; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30158; ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER; 1.
DR PANTHER; PTHR30158:SF3; MULTIDRUG EFFLUX PUMP SUBUNIT ACRA-RELATED; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000008207};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..385
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002874138"
FT DOMAIN 35..358
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT DOMAIN 59..290
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT COILED 101..166
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 385 AA; 41541 MW; 6605437B49CA2797 CRC64;
MTHRRLALAA FAALALAACK PTQQSAAPAE TLPTEVSIVT VRNQPIPFER ELPGRVAPTR
IAEVRARVSG LVVKRAFQQG SQVKEGDLLY KIDPAPYRVE LDSVEATLAR AEAALVLARQ
QAERLETLLA RQTASQAQYD AAYAAQKQAE AEVAGARAAR DRARLNLSYT DVRAPISGRI
GRALVTEGAL IEQGSATNLA TIQQLDPIYV DITQSVSELN KLRRDLASGE LASIAPDTAS
VRLIMDDGSL YSEPGRLLFS DVTADPSTGQ VTLRVEIPNP HNELFPGMYV RARIRQGIDA
DAIAVPQQAV HRSNDGRAEV WLVGEGDKVM LHPVEVGPVV EGQWVIRDGL KAGDRVVTEG
FQKIVAGTVV KTVPWQTAAA GTDRR
//
