ID B8IPU5_METNO Unreviewed; 830 AA.
AC B8IPU5;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=Mnod_1605 {ECO:0000313|EMBL:ACL56595.1};
OS Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Methylobacteriaceae; Methylobacterium.
OX NCBI_TaxID=460265 {ECO:0000313|EMBL:ACL56595.1, ECO:0000313|Proteomes:UP000008207};
RN [1] {ECO:0000313|EMBL:ACL56595.1, ECO:0000313|Proteomes:UP000008207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 21967 / CNCM I-2342 / ORS 2060
RC {ECO:0000313|Proteomes:UP000008207};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Marx C.J.,
RA Richardson P.;
RT "Complete sequence of chromosome of Methylobacterium nodulans ORS 2060.";
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP001349; ACL56595.1; -; Genomic_DNA.
DR RefSeq; WP_015928290.1; NC_011894.1.
DR AlphaFoldDB; B8IPU5; -.
DR STRING; 460265.Mnod_1605; -.
DR KEGG; mno:Mnod_1605; -.
DR eggNOG; COG2205; Bacteria.
DR HOGENOM; CLU_018130_0_0_5; -.
DR OrthoDB; 9797304at2; -.
DR Proteomes; UP000008207; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR43047:SF72; OSMOSENSING HISTIDINE PROTEIN KINASE SLN1; 1.
DR PANTHER; PTHR43047; TWO-COMPONENT HISTIDINE PROTEIN KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF12860; PAS_7; 2.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00091; PAS; 3.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 3.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:ACL56595.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008207};
KW Transferase {ECO:0000313|EMBL:ACL56595.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 46..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 604..821
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 830 AA; 89793 MW; 7592233E428CA88A CRC64;
MGVGRTLRCR PRAGAVAGAW AAAAALTVVP GGAAQAQPLL PATGALAHNA MALALLIGLI
VFSTILSLLH IRERGRWARR EHDLVAELAD LRGAHDRAAL LLGSERQIII TWCGRDEPQI
EGDASLAMDG TRSASPRRVL AFGTWLSAAD AAALDAAVDT LRSRGERFRL TVRTLGGRTI
EAQGQAVSGR ALLRLRELTG ERQELVELRA MLQEARGSLS VLAALLDAIP QPVWRRGRDG
RLLWANAAYV AAVEAGDRER ALAEGTELLD RVAREEAGRR RSSGQGGALR VSAVMAGARR
TLDVTEVAVE SGSVGIAVDV SELESVRADL QRQMEANART LDQLPTAVAI FDARQRLIFH
NAAYRQLWDL DPGFLDGNPL DGEILDALRN ARKLPEQADF RSWKTGVLSA YRAAEAQENW
WHLPDGRTLR VVADPNPQGG LTYLFDDVSE RVHLESRYNA LMRVQSETLD TLREPVAVFG
SDGRLKLANR AFTAIWRIGP ELLGTQPHID EVIALCRPLS PAEEPWTEIR GAVTGLMDAR
HALACRLALK DGTVLDCAAQ PLPDGATLLT HIDVTASVNV ERALTEKNEA LERTARLRDE
FVHHVSYELR SPLTNIIGFT ELLGDETVGA LNTRQREYAD HIMRSSAALL VIINDILDLA
SIDAGSMELT REVVDVQATI AAAVRGVEDR LAEAAITLDR DVPADIGGFV ADGKRIRQIL
FNLLSNAIGF SAPGQTVVVQ ARKTDREIAF AVIDQGRGMP PEVVARVFDR FESHTLGTRH
RGVGLGLSIV RSFVELHGGR IDIASAPGQG TKVTCTFPIS GSEPSLAAAE
//
