ID   B8IRC0_METNO            Unreviewed;       537 AA.
AC   B8IRC0;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 75.
DE   SubName: Full=Glucose-methanol-choline oxidoreductase {ECO:0000313|EMBL:ACL58660.1};
GN   OrderedLocusNames=Mnod_3754 {ECO:0000313|EMBL:ACL58660.1};
OS   Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=460265 {ECO:0000313|EMBL:ACL58660.1, ECO:0000313|Proteomes:UP000008207};
RN   [1] {ECO:0000313|EMBL:ACL58660.1, ECO:0000313|Proteomes:UP000008207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 21967 / CNCM I-2342 / ORS 2060
RC   {ECO:0000313|Proteomes:UP000008207};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Marx C.J.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium nodulans ORS 2060.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974,
CC         ECO:0000256|PIRSR:PIRSR000137-2};
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC       {ECO:0000256|ARBA:ARBA00010790, ECO:0000256|RuleBase:RU003968}.
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DR   EMBL; CP001349; ACL58660.1; -; Genomic_DNA.
DR   RefSeq; WP_015930316.1; NC_011894.1.
DR   AlphaFoldDB; B8IRC0; -.
DR   STRING; 460265.Mnod_3754; -.
DR   KEGG; mno:Mnod_3754; -.
DR   eggNOG; COG2303; Bacteria.
DR   HOGENOM; CLU_002865_7_2_5; -.
DR   OrthoDB; 9785276at2; -.
DR   Proteomes; UP000008207; Chromosome.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   PANTHER; PTHR11552:SF147; CHOLINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 1.
DR   PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   PROSITE; PS00623; GMC_OXRED_1; 1.
DR   PROSITE; PS00624; GMC_OXRED_2; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRSR:PIRSR000137-2};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW   ECO:0000256|RuleBase:RU003968};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008207}.
FT   DOMAIN          86..109
FT                   /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS00623"
FT   DOMAIN          258..272
FT                   /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS00624"
FT   BINDING         223
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ   SEQUENCE   537 AA;  58004 MW;  F627C880F3BF04B4 CRC64;
     MGQDQAETFD YIIVGGGTAG CVLANRLSAS GSRTVLLLEA GRQARHPWIT IPAGFSKLLT
     NPAYNWRFQT EPEEATGGRV IAVPRGKGLG GSTLINGMIY VRGQPQDFDH WAQAGCTGWG
     FEDVLPYFRR IEDYDGAADP LRARGGPLPI TTVAERPVIA EAFIAAAQAA GFARNPDYNA
     ASQDGFGYYQ VNQRGGRRVS AADAYLTPAR RRPNLSVRTD AHVLRLTLAE GRATGVEVRI
     GGEERRFAAR GEVILAAGAA QTPQILELSG IGDPAILSAI GVPVRHAAPG VGANYIDHYC
     TRMNWRVKLP VTLNEATRGW RLALSVAQYA VLRRGILTLG TGLAHGFVRT RPGLEGPDIQ
     YFFMHASYAN AAERKLDLEP GMTVGVTQLR PQSRGTIHAA SADPFAAPVI RPNFLATEED
     RRAMVEGMKI ARHIVEQAPM DPYRARELNP GPDCRTDADW LDFARRDGQT IYHICGTCRM
     GRDALAVTDP ALRVRGLRGL RVADASVMPD IVSGNTQAAV FMIAEKAADL IRADAAG
//