ID B8JJX9_MOUSE Unreviewed; 182 AA.
AC B8JJX9;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 2.
DT 27-MAR-2024, entry version 110.
DE SubName: Full=Zinc finger protein 65 {ECO:0000313|Ensembl:ENSMUSP00000117218.3};
DE Flags: Fragment;
GN Name=Zfp65 {ECO:0000313|Ensembl:ENSMUSP00000117218.3,
GN ECO:0000313|MGI:MGI:107769};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000117218.3, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000117218.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000117218.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000117218.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000117218.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; B8JJX9; -.
DR SMR; B8JJX9; -.
DR PeptideAtlas; B8JJX9; -.
DR ProteomicsDB; 363375; -.
DR Ensembl; ENSMUST00000127979.9; ENSMUSP00000117218.3; ENSMUSG00000071281.13.
DR AGR; MGI:107769; -.
DR MGI; MGI:107769; Zfp65.
DR VEuPathDB; HostDB:ENSMUSG00000071281; -.
DR GeneTree; ENSGT00940000169481; -.
DR HOGENOM; CLU_002678_2_1_1; -.
DR OMA; VIMREFE; -.
DR ChiTaRS; Zfp65; mouse.
DR Proteomes; UP000000589; Chromosome 13.
DR Bgee; ENSMUSG00000071281; Expressed in cortical plate and 66 other cell types or tissues.
DR ExpressionAtlas; B8JJX9; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 3.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR PANTHER; PTHR23232:SF147; KRAB DOMAIN-CONTAINING PROTEIN 5-RELATED; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 2..73
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 78..105
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 106..133
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 134..161
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 162..182
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT NON_TER 182
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000117218.3"
SQ SEQUENCE 182 AA; 20883 MW; 3A8D3FA33295A0AB CRC64;
MLSFRDVAID FSEEEWECLG PAQWNLYRDV MLENYSHLVF LGLALSKPYL VTCLEKIQET
SGVKRGGAPF MLPGGKCYTC TECGKIFEWK KVFQNHQMLD LRMNPYKCEE CAKSFHSPSL
SSKESRIHTG GKPYKCEVCG KAFCIPLLLS KHKIIHTVEK PYKCDICGKA FQYPSKLSRH
KQ
//
