ID B8JLJ3_DANRE Unreviewed; 244 AA.
AC B8JLJ3; A0A8M1PI77;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide {ECO:0000313|Ensembl:ENSDARP00000041959, ECO:0000313|RefSeq:NP_997922.2};
GN Name=ywhaz {ECO:0000313|Ensembl:ENSDARP00000041959,
GN ECO:0000313|RefSeq:NP_997922.2,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-8554};
GN Synonyms=fb14h09 {ECO:0000313|RefSeq:NP_997922.2}, wu:fb05g08
GN {ECO:0000313|RefSeq:NP_997922.2}, wu:fb14h09
GN {ECO:0000313|RefSeq:NP_997922.2}, ywhai
GN {ECO:0000313|RefSeq:NP_997922.2}, zgc:55807
GN {ECO:0000313|RefSeq:NP_997922.2};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000041959};
RN [1] {ECO:0000313|RefSeq:NP_997922.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_997922.2};
RX PubMed=16412219;
RA Link V., Shevchenko A., Heisenberg C.P.;
RT "Proteomics of early zebrafish embryos.";
RL BMC Dev. Biol. 6:1-1(2006).
RN [2] {ECO:0000313|RefSeq:NP_997922.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_997922.2};
RX PubMed=17548429;
RA Jia S., Omelchenko M., Garland D., Vasiliou V., Kanungo J., Spencer M.,
RA Wolf Y., Koonin E., Piatigorsky J.;
RT "Duplicated gelsolin family genes in zebrafish: a novel scinderin-like gene
RT (scinla) encodes the major corneal crystallin.";
RL FASEB J. 21:3318-3328(2007).
RN [3] {ECO:0000313|RefSeq:NP_997922.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_997922.2};
RX PubMed=17127101;
RA Besser J., Bagowski C.P., Salas-Vidal E., van Hemert M.J., Bussmann J.,
RA Spaink H.P.;
RT "Expression analysis of the family of 14-3-3 proteins in zebrafish
RT development.";
RL Gene Expr. Patterns 7:511-520(2007).
RN [4] {ECO:0000313|Ensembl:ENSDARP00000041959, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000041959};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|Ensembl:ENSDARP00000041959}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000041959};
RG Ensembl;
RL Submitted (MAY-2013) to UniProtKB.
RN [6] {ECO:0000313|RefSeq:NP_997922.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_997922.2};
RX PubMed=24714733;
RA Tseng L.C., Zhang C., Cheng C.M., Xu H., Hsu C.H., Jiang Y.J.;
RT "New classes of mind bomb-interacting proteins identified from yeast two-
RT hybrid screens.";
RL PLoS ONE 9:e93394-e93394(2014).
RN [7] {ECO:0000313|RefSeq:NP_997922.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_997922.2};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [8] {ECO:0000313|RefSeq:NP_997922.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_997922.2};
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [9] {ECO:0000313|RefSeq:NP_997922.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_997922.2};
RX PubMed=29653226;
RA Cao J., Tan X.;
RT "Comparative and evolutionary analysis of the 14-3-3 family genes in eleven
RT fishes.";
RL Gene 662:76-82(2018).
RN [10] {ECO:0000313|RefSeq:NP_997922.2}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_997922.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer, and heterodimer with other family members.
CC {ECO:0000256|ARBA:ARBA00011625}.
CC -!- SIMILARITY: Belongs to the 14-3-3 family.
CC {ECO:0000256|ARBA:ARBA00006141, ECO:0000256|RuleBase:RU003466}.
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DR EMBL; CU468824; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_997922.2; NM_212757.2.
DR STRING; 7955.ENSDARP00000041959; -.
DR PaxDb; 7955-ENSDARP00000041959; -.
DR PeptideAtlas; B8JLJ3; -.
DR Ensembl; ENSDART00000041960; ENSDARP00000041959; ENSDARG00000032575.
DR Ensembl; ENSDART00000041960.7; ENSDARP00000041959.6; ENSDARG00000032575.7.
DR GeneID; 336610; -.
DR KEGG; dre:336610; -.
DR AGR; ZFIN:ZDB-GENE-030131-8554; -.
DR CTD; 7534; -.
DR ZFIN; ZDB-GENE-030131-8554; ywhaz.
DR eggNOG; KOG0841; Eukaryota.
DR HOGENOM; CLU_058290_1_0_1; -.
DR OMA; DKQQMAK; -.
DR OrthoDB; 920089at2759; -.
DR PhylomeDB; B8JLJ3; -.
DR TreeFam; TF102003; -.
DR Proteomes; UP000000437; Chromosome 19.
DR Bgee; ENSDARG00000032575; Expressed in zone of skin and 42 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.20.190.20; 14-3-3 domain; 1.
DR InterPro; IPR000308; 14-3-3.
DR InterPro; IPR023409; 14-3-3_CS.
DR InterPro; IPR036815; 14-3-3_dom_sf.
DR InterPro; IPR023410; 14-3-3_domain.
DR PANTHER; PTHR18860; 14-3-3 PROTEIN; 1.
DR PANTHER; PTHR18860:SF7; 14-3-3 PROTEIN ZETA_DELTA; 1.
DR Pfam; PF00244; 14-3-3; 1.
DR PIRSF; PIRSF000868; 14-3-3; 1.
DR PRINTS; PR00305; 1433ZETA.
DR SMART; SM00101; 14_3_3; 1.
DR SUPFAM; SSF48445; 14-3-3 protein; 1.
DR PROSITE; PS00796; 1433_1; 1.
DR PROSITE; PS00797; 1433_2; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:B8JLJ3};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 3..241
FT /note="14-3-3"
FT /evidence="ECO:0000259|SMART:SM00101"
FT SITE 56
FT /note="Interaction with phosphoserine on interacting
FT protein"
FT /evidence="ECO:0000256|PIRSR:PIRSR000868-1"
FT SITE 126
FT /note="Interaction with phosphoserine on interacting
FT protein"
FT /evidence="ECO:0000256|PIRSR:PIRSR000868-1"
SQ SEQUENCE 244 AA; 27962 MW; 026AF47E1C554A74 CRC64;
MDKSQHVQRA KLAEQAERYD DMADSMKKVT ELGEELSDEE RNLLSVAYKN VVGARRSAWR
VVSSIEQKTE GTDKKQMAQE YREKIEAELK AICNDVLHLL DKFLIRSTSP AESQVFYLKM
KGDYYRYLAE VATGDEKTNI IQKSQEGYQA AFDISKDNMQ PTHPIRLGLA LNFSVFYYEI
LNSPEQACDL AKKAFDDAIS ELDQLTEDSY KDSTLIMQLL RDNLTLWTSD NQADGDETEE
GRQN
//
