ID B8KTR7_9GAMM Unreviewed; 715 AA.
AC B8KTR7;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 24-JAN-2024, entry version 69.
DE SubName: Full=Fatty acid oxidation complex, alpha subunit {ECO:0000313|EMBL:EED34528.1};
DE EC=1.1.1.35 {ECO:0000313|EMBL:EED34528.1};
DE EC=4.2.1.17 {ECO:0000313|EMBL:EED34528.1};
DE EC=5.1.2.3 {ECO:0000313|EMBL:EED34528.1};
GN Name=fadJ {ECO:0000313|EMBL:EED34528.1};
GN ORFNames=NOR51B_465 {ECO:0000313|EMBL:EED34528.1};
OS Luminiphilus syltensis NOR5-1B.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales; Halieaceae;
OC Luminiphilus.
OX NCBI_TaxID=565045 {ECO:0000313|EMBL:EED34528.1, ECO:0000313|Proteomes:UP000004699};
RN [1] {ECO:0000313|Proteomes:UP000004699}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NOR51-B {ECO:0000313|Proteomes:UP000004699};
RX PubMed=23705883;
RA Spring S., Riedel T., Sproer C., Yan S., Harder J., Fuchs B.M.;
RT "Taxonomy and evolution of bacteriochlorophyll a-containing members of the
RT OM60/NOR5 clade of marine gammaproteobacteria: description of Luminiphilus
RT syltensis gen. nov., sp. nov., reclassification of Haliea rubra as
RT Pseudohaliea rubra gen. nov., comb. nov., and emendation of Chromatocurvus
RT halotolerans.";
RL BMC Microbiol. 13:118-118(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: In the central section; belongs to the 3-hydroxyacyl-CoA
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00007005}.
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DR EMBL; DS999411; EED34528.1; -; Genomic_DNA.
DR RefSeq; WP_009019276.1; NZ_DS999411.1.
DR AlphaFoldDB; B8KTR7; -.
DR STRING; 565045.NOR51B_465; -.
DR eggNOG; COG1024; Bacteria.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_009834_15_3_6; -.
DR OrthoDB; 5389341at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000004699; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43612; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA; 1.
DR PANTHER; PTHR43612:SF3; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Isomerase {ECO:0000313|EMBL:EED34528.1};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:EED34528.1};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EED34528.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000004699}.
FT DOMAIN 319..497
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 500..599
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 715 AA; 77234 MW; 75C7C4E3E8EAB4D9 CRC64;
MSGFNYEKDG DGIVTITMDM DGPVNSMSAE YGPMMKATVD RLEAESDLTG VVIASAKKTF
FAGGDLKMLA QVTSETAGEF FEGCEAVKAD LRRLERLPVP VAAAINGAAL GGGLEICLAC
NYRVAWDDKS VKLGLPEVTL GLLPGGGGIV RMIHLLGLMA SNEFLLEGKQ VDPARAKEAG
IIHEVVASRD ELVGLAKAWI LANKDNEDAA VQPWDRKGHK IPGGNANTPS LAQMIPAAAP
MLIKKTRGLL PAPEKILDVA VSALRVDFDT ALRIESRGLT YLVQTAVAKN MINTFFFQLN
KVNGGASRPS DVEPQATKKV GVLGAGMMGQ GIAYVSAMAG IEVVLKDIDK DAAIKGKGYS
EKLLQKRVDK GRMTAEKMQE VLALITPSAD NADLEGCDLI IEAVFENMTL KHKITKETEP
CLAEGGVWGS NTSTLPITEL AEASINPENF IGIHFFSPVD KMPLVEIICG EQTGDVALAK
AFDFARQIRK TPIVVNDSLG FFTSRTFATY LEEGARLVME GLHPIKIDNL GKAIGMPVGP
LTIQDEVSQE LSRKAQATWV ELGYADRFGD QSQYRDFIDW MVLENDRGGR HHGGGYYDYH
ADGSKTLWPV VVDKYYKPEV SLADEDVKDR LLFRQVIEAL KCLESGVLRT VADGNVGSIM
GIGAPVWTGG FIQFVNTYGL DKFIARCEEL SAAYGDRFDP PAIVAEKLAA GENFS
//