ID B8LBW0_THAPS Unreviewed; 944 AA.
AC B8LBW0;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE RecName: Full=Rad4 beta-hairpin domain-containing protein {ECO:0000259|SMART:SM01030};
GN ORFNames=THAPSDRAFT_8733 {ECO:0000313|EMBL:EED87252.1};
OS Thalassiosira pseudonana (Marine diatom) (Cyclotella nana).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Coscinodiscophyceae; Thalassiosirophycidae; Thalassiosirales;
OC Thalassiosiraceae; Thalassiosira.
OX NCBI_TaxID=35128 {ECO:0000313|EMBL:EED87252.1, ECO:0000313|Proteomes:UP000001449};
RN [1] {ECO:0000313|EMBL:EED87252.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:EED87252.1};
RX PubMed=15459382; DOI=10.1126/science.1101156;
RA Armbrust E.V., Berges J.A., Bowler C., Green B.R., Martinez D.,
RA Putnam N.H., Zhou S., Allen A.E., Apt K.E., Bechner M., Brzezinski M.A.,
RA Chaal B.K., Chiovitti A., Davis A.K., Demarest M.S., Detter J.C.,
RA Glavina T., Goodstein D., Hadi M.Z., Hellsten U., Hildebrand M.,
RA Jenkins B.D., Jurka J., Kapitonov V.V., Kroger N., Lau W.W., Lane T.W.,
RA Larimer F.W., Lippmeier J.C., Lucas S., Medina M., Montsant A., Obornik M.,
RA Parker M.S., Palenik B., Pazour G.J., Richardson P.M., Rynearson T.A.,
RA Saito M.A., Schwartz D.C., Thamatrakoln K., Valentin K., Vardi A.,
RA Wilkerson F.P., Rokhsar D.S.;
RT "The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and
RT metabolism.";
RL Science 306:79-86(2004).
RN [2] {ECO:0000313|EMBL:EED87252.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:EED87252.1};
RX PubMed=18923393; DOI=10.1038/nature07410;
RA Bowler C., Allen A.E., Badger J.H., Grimwood J., Jabbari K., Kuo A.,
RA Maheswari U., Martens C., Maumus F., Otillar R.P., Rayko E., Salamov A.,
RA Vandepoele K., Beszteri B., Gruber A., Heijde M., Katinka M., Mock T.,
RA Valentin K., Verret F., Berges J.A., Brownlee C., Cadoret J.P.,
RA Chiovitti A., Choi C.J., Coesel S., De Martino A., Detter J.C., Durkin C.,
RA Falciatore A., Fournet J., Haruta M., Huysman M.J., Jenkins B.D.,
RA Jiroutova K., Jorgensen R.E., Joubert Y., Kaplan A., Kroger N., Kroth P.G.,
RA La Roche J., Lindquist E., Lommer M., Martin-Jezequel V., Lopez P.J.,
RA Lucas S., Mangogna M., McGinnis K., Medlin L.K., Montsant A.,
RA Oudot-Le Secq M.P., Napoli C., Obornik M., Parker M.S., Petit J.L.,
RA Porcel B.M., Poulsen N., Robison M., Rychlewski L., Rynearson T.A.,
RA Schmutz J., Shapiro H., Siaut M., Stanley M., Sussman M.R., Taylor A.R.,
RA Vardi A., von Dassow P., Vyverman W., Willis A., Wyrwicz L.S.,
RA Rokhsar D.S., Weissenbach J., Armbrust E.V., Green B.R., Van de Peer Y.,
RA Grigoriev I.V.;
RT "The Phaeodactylum genome reveals the evolutionary history of diatom
RT genomes.";
RL Nature 456:239-244(2008).
RN [3] {ECO:0000313|EMBL:EED87252.1}
RP GENOME REANNOTATION.
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:EED87252.1};
RG Diatom Consortium;
RA Grigoriev I., Grimwood J., Kuo A., Otillar R.P., Salamov A., Detter J.C.,
RA Schmutz J., Lindquist E., Shapiro H., Lucas S., Glavina del Rio T.,
RA Bruce D., Pitluck S., Rokhsar D., Armbrust V.;
RL Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
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DR EMBL; DS999415; EED87252.1; -; Genomic_DNA.
DR RefSeq; XP_002296556.1; XM_002296520.1.
DR AlphaFoldDB; B8LBW0; -.
DR STRING; 35128.B8LBW0; -.
DR PaxDb; 35128-Thaps8733; -.
DR EnsemblProtists; EED87252; EED87252; THAPSDRAFT_8733.
DR GeneID; 7443294; -.
DR KEGG; tps:THAPSDRAFT_8733; -.
DR eggNOG; KOG2179; Eukaryota.
DR HOGENOM; CLU_333581_0_0_1; -.
DR InParanoid; B8LBW0; -.
DR OMA; ICGVFKG; -.
DR Proteomes; UP000001449; Chromosome 11.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0000111; C:nucleotide-excision repair factor 2 complex; IBA:GO_Central.
DR GO; GO:0071942; C:XPC complex; IBA:GO_Central.
DR GO; GO:0003684; F:damaged DNA binding; IBA:GO_Central.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR GO; GO:0006289; P:nucleotide-excision repair; IBA:GO_Central.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR PANTHER; PTHR12135:SF0; DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10404; BHD_2; 1.
DR SMART; SM01030; BHD_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001449}.
FT DOMAIN 749..802
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01030"
FT REGION 30..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..92
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..107
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..352
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..574
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..746
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 944 AA; 104253 MW; CCAF13792245A709 CRC64;
MSFQFDDNDS EEDIDLDDFD DTGLLALASR ETAASRPSTD ITSEVAAPRV AAELGVGITE
TSAYHDGEGD DRGDWSDVDW EDADQEDGEG EGIDSGGDGK QDNVDELQPR KFPSEGIMIN
FGASESNTNS TNSGDDNGDD AKDKEYKPKK WKRTRTLRDV PFATQQLVLN VRRAHMLCCI
SYSLGCSAVC GGGVMIHEDD IMKAASDDEM EGTRSFLTCL AHSLVPLEFH QSDTVDHGLQ
ATTKPKKSYI IPTTQQLHQF SQWYFGFVNR AGERRRAALE RNVAQGAATT SFVVASRVSA
SKKRAITLGS NTNGRQATKS VELKDTKPPA KKQRRRGEAD APEDDEGGEK PSCTEPMMHQ
HYTSTTTSLV QKLKYFSPCY DEDPQLFIKE EGLDVIHAVE SITPDEKVLI FLTMVRAMGW
RARYVVALNP LSLELTVDHP LLASNSELMS STDCYGSLDQ SNNKRVTKVP NEKEPNTNTD
NATMSETCLS WIEVLCGNDD SKLSNDDKRK PKSTPKQLVA RWIPVFPEQE TVDKPEEVES
ILAWIRDITT ESSPSKKTTQ TKKKSTRRNI ARKSLRRQSS NSYAKKAPVS YVLATEHFPP
IMKSTTTPFD VSSKSLRGAR FTDVTPRYAN TWSRTLRLRG ATARQLKAGG GKCVDEWWAT
SLKDINGMCS SAKNKSSLAL ANDIVNTEPE IRVSVTKTVS GSGKEVEVLE IDSSGDEKPA
AMDTNNDSGA SDHDEHDNDE SVELTKTTSK EAIPTSKKAF RENPFYVIPS VLNSQDVLHP
DAHKRICGVF KGELVYKRSD VSKALRAKKW LYEGRKVKEN EIPTPAKQIN ARKKPTSQGQ
GFKALESYVT ETTLPSKYSE AGDGNAMENL YGIWQTAPWS PPHVGPSDPI PTNEFKNVEL
ALLNPGLDLK VVGAIGHHLL EELSYIRITL SSCVKHISSG RVTP
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