ID B8LTH8_TALSN Unreviewed; 528 AA.
AC B8LTH8;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=alcohol oxidase {ECO:0000256|ARBA:ARBA00013077};
DE EC=1.1.3.13 {ECO:0000256|ARBA:ARBA00013077};
GN ORFNames=TSTA_065150 {ECO:0000313|EMBL:EED23056.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED23056.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a primary alcohol + O2 = an aldehyde + H2O2;
CC Xref=Rhea:RHEA:19829, ChEBI:CHEBI:15379, ChEBI:CHEBI:15734,
CC ChEBI:CHEBI:16240, ChEBI:CHEBI:17478; EC=1.1.3.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001411};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- PATHWAY: Energy metabolism; methane degradation.
CC {ECO:0000256|ARBA:ARBA00005144}.
CC -!- SUBCELLULAR LOCATION: Peroxisome matrix
CC {ECO:0000256|ARBA:ARBA00004253}.
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
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DR EMBL; EQ962652; EED23056.1; -; Genomic_DNA.
DR RefSeq; XP_002340443.1; XM_002340402.1.
DR AlphaFoldDB; B8LTH8; -.
DR GeneID; 8102319; -.
DR VEuPathDB; FungiDB:TSTA_065150; -.
DR OrthoDB; 2392848at2759; -.
DR PhylomeDB; B8LTH8; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0047639; F:alcohol oxidase activity; IEA:UniProtKB-EC.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR PANTHER; PTHR11552:SF119; GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|PIRSR:PIRSR000137-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR000137-2};
KW Methanol utilization {ECO:0000256|ARBA:ARBA00023095};
KW Oxidoreductase {ECO:0000313|EMBL:EED23056.1};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000001745}.
FT DOMAIN 269..283
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
FT BINDING 89
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT BINDING 227
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ SEQUENCE 528 AA; 59351 MW; 04DFC731290D6112 CRC64;
MTVPEEVDVI ICGGGSTGCV PAGRLANLDH NLQVLLIEAG EDNLNNPWVY RPGIYPRNMK
LDSKTASFYY SRPSEWLDGR RAIVPCAHVL GGGSSINFMM YTRASASDYD DFQAKGWTTK
DLLPLMKKHE TYQRACNNPD IHGFEGPIKV SFGNYTYPIM QDFLRAAESQ GIPVTDDLQD
LTTGHGAEHW LKWINRDTGR RSDAAHAYVH STRAKHSNLH LKCNTKVDKI IIENGRAVGV
VTVPTKWVGD GEPPRKIYRA RKQIIISGGT MSSPLILQRS GIGDPEKLRR AGIKPLVDLP
GVGLNFQDHY LTFSVYRAKP DTESFDDFIR GDPQTQKKVF EEWNTKGTGP LATNGIDAGV
KIRPTEEELA QIRSWPTPDF QRGWDSYFKH KPDKPVMHYS VISGWFGDHM LMPPGKFFTM
FHFLEYPFSR GWIHVKSADP YEAPDFDAGF MNDKRDMAPM VWGYIKSRET ARRMAAYAGE
VTGMHPHFAH DSPARAYDMD LETTKAYAGP DHLSAGIQHV LSNQASRL
//
